"Imipenem" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to beta-lactamases. Clinical studies have demonstrated high efficacy in the treatment of infections of various body systems. Its effectiveness is enhanced when it is administered in combination with CILASTATIN, a renal dipeptidase inhibitor.
| Descriptor ID |
D015378
|
| MeSH Number(s) |
D02.065.589.099.124.300.500 D03.633.100.300.124.300.500
|
| Concept/Terms |
Imipenem- Imipenem
- N-Formimidoylthienamycin
- N Formimidoylthienamycin
- Imipemide
|
Below are MeSH descriptors whose meaning is more general than "Imipenem".
Below are MeSH descriptors whose meaning is more specific than "Imipenem".
This graph shows the total number of publications written about "Imipenem" by people in this website by year, and whether "Imipenem" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 |
| 2001 | 1 | 0 | 1 |
| 2004 | 0 | 1 | 1 |
| 2010 | 0 | 2 | 2 |
| 2012 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Imipenem" by people in Profiles.
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Gram-negative Bacteria With Difficult-to-Treat Resistance: A Moving Target. Clin Infect Dis. 2021 06 15; 72(12):2121-2123.
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The role of the ?5-a11 loop in the active-site dynamics of acylated penicillin-binding protein A from Mycobacterium tuberculosis. J Mol Biol. 2012 May 18; 418(5):316-30.
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Empiric, broad-spectrum antibiotic therapy with an aggressive de-escalation strategy does not induce gram-negative pathogen resistance in ventilator-associated pneumonia. Surg Infect (Larchmt). 2010 Oct; 11(5):427-32.
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Crystal structures of covalent complexes of ?-lactam antibiotics with Escherichia coli penicillin-binding protein 5: toward an understanding of antibiotic specificity. Biochemistry. 2010 Sep 21; 49(37):8094-104.
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Asaia bogorensis peritonitis identified by 16S ribosomal RNA sequence analysis in a patient receiving peritoneal dialysis. Am J Kidney Dis. 2004 Aug; 44(2):e15-7.
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Comparative in vitro pharmacodynamics of imipenem and meropenem against ATCC strains of Escherichia coli, Staphylococcus aureus and Bacteroides fragilis. Diagn Microbiol Infect Dis. 2001 Jan; 39(1):39-47.
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A pharmacodynamic model for the action of the antibiotic imipenem on Pseudomonas aeruginosa populations in vitro. Bull Math Biol. 1996 Sep; 58(5):923-38.
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Pseudoresistance of Pseudomonas aeruginosa resulting from degradation of imipenem in an automated susceptibility testing system with predried panels. J Clin Microbiol. 1991 Feb; 29(2):398-400.
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In vitro activity of N-formimidoyl thienamycin, moxalactam, and other new beta-lactam agents against Bacteroides fragilis: contribution of beta-lactamase to resistance. Antimicrob Agents Chemother. 1981 Feb; 19(2):248-52.