Mineralocorticoid Excess Syndrome, Apparent
"Mineralocorticoid Excess Syndrome, Apparent" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A hereditary disease characterized by childhood onset HYPERTENSION, hypokalemic alkalosis, and low RENIN and ALDOSTERONE secretion. It results from a defect in the activity of the 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 2 enzyme which results in inadequate conversion of CORTISOL to CORTISONE. The build up of unprocessed cortisol to levels that stimulate MINERALOCORTICOID RECEPTORS creates the appearance of having excessive MINERALOCORTICOIDS.
| Descriptor ID |
D043204
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| MeSH Number(s) |
C16.320.565.925.500 C18.452.648.925.500
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Mineralocorticoid Excess Syndrome, Apparent".
Below are MeSH descriptors whose meaning is more specific than "Mineralocorticoid Excess Syndrome, Apparent".
This graph shows the total number of publications written about "Mineralocorticoid Excess Syndrome, Apparent" by people in this website by year, and whether "Mineralocorticoid Excess Syndrome, Apparent" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2004 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
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Below are the most recent publications written about "Mineralocorticoid Excess Syndrome, Apparent" by people in Profiles.
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Clinical, genetic, and structural basis of apparent mineralocorticoid excess due to 11?-hydroxysteroid dehydrogenase type 2 deficiency. Proc Natl Acad Sci U S A. 2017 12 26; 114(52):E11248-E11256.
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A novel mutation in HSD11B2 causes apparent mineralocorticoid excess in an Omani kindred. Ann N Y Acad Sci. 2016 07; 1376(1):65-71.
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In vitro expression studies of a novel mutation delta299 in a patient affected with apparent mineralocorticoid excess. J Clin Endocrinol Metab. 2004 May; 89(5):2024-7.
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Hypertension and adrenal disorders. Curr Hypertens Rep. 2003 Dec; 5(6):498-504.