"Ligase Chain Reaction" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A DNA amplification technique based upon the ligation of OLIGONUCLEOTIDE PROBES. The probes are designed to exactly match two adjacent sequences of a specific target DNA. The chain reaction is repeated in three steps in the presence of excess probe: (1) heat denaturation of double-stranded DNA, (2) annealing of probes to target DNA, and (3) joining of the probes by thermostable DNA ligase. After the reaction is repeated for 20-30 cycles the production of ligated probe is measured.
| Descriptor ID |
D022521
|
| MeSH Number(s) |
E05.393.620.311
|
| Concept/Terms |
Ligase Chain Reaction- Ligase Chain Reaction
- Chain Reaction, Ligase
- Chain Reactions, Ligase
- Ligase Chain Reactions
- Reaction, Ligase Chain
- Reactions, Ligase Chain
|
Below are MeSH descriptors whose meaning is more general than "Ligase Chain Reaction".
Below are MeSH descriptors whose meaning is more specific than "Ligase Chain Reaction".
This graph shows the total number of publications written about "Ligase Chain Reaction" by people in this website by year, and whether "Ligase Chain Reaction" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2010 | 0 | 1 | 1 |
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Below are the most recent publications written about "Ligase Chain Reaction" by people in Profiles.
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Frequency of deletions of EPCAM (TACSTD1) in MSH2-associated Lynch syndrome cases. J Mol Diagn. 2011 Jan; 13(1):93-9.