Dual Specificity Phosphatase 1
"Dual Specificity Phosphatase 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A dual specificity phosphatase subtype that plays a role in intracellular signal transduction by inactivating MITOGEN-ACTIVATED PROTEIN KINASES. It has specificity for P38 MITOGEN-ACTIVATED PROTEIN KINASES and JNK MITOGEN-ACTIVATED PROTEIN KINASES.
| Descriptor ID |
D054638
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| MeSH Number(s) |
D08.811.277.352.650.587.200 D08.811.277.352.650.625.225.200 D08.811.277.352.650.775.250.200 D08.811.641.755.200 D12.644.360.268.200 D12.644.360.445.100 D12.776.476.268.200 D12.776.476.445.200
|
| Concept/Terms |
Dual Specificity Phosphatase 1- Dual Specificity Phosphatase 1
- CL100 Phosphatase
- Phosphatase, CL100
- Externally Regulated Phosphatase (ERP)
- MKP-1 Phosphatase
- MKP 1 Phosphatase
- Phosphatase, MKP-1
- MAP Phosphatase-1
- MAP Phosphatase 1
- Phosphatase-1, MAP
- MAPK Phosphatase
- Phosphatase, MAPK
- Mitogen-Activated Protein Phosphatase-1
- Mitogen Activated Protein Phosphatase 1
- Phosphatase-1, Mitogen-Activated Protein
- Protein Phosphatase-1, Mitogen-Activated
- 3CH134 Phosphatase
- Phosphatase, 3CH134
- Map Kinase Phosphatase 1
|
Below are MeSH descriptors whose meaning is more general than "Dual Specificity Phosphatase 1".
Below are MeSH descriptors whose meaning is more specific than "Dual Specificity Phosphatase 1".
This graph shows the total number of publications written about "Dual Specificity Phosphatase 1" by people in this website by year, and whether "Dual Specificity Phosphatase 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 2 | 2 |
| 2002 | 0 | 2 | 2 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2008 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2012 | 3 | 0 | 3 |
| 2013 | 1 | 1 | 2 |
| 2014 | 2 | 0 | 2 |
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Below are the most recent publications written about "Dual Specificity Phosphatase 1" by people in Profiles.
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DUSP1 phosphatase regulates the proinflammatory milieu in head and neck squamous cell carcinoma. Cancer Res. 2014 Dec 15; 74(24):7191-7.
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Critical role of MKP-1 in lipopolysaccharide-induced osteoclast formation through CXCL1 and CXCL2. Cytokine. 2015 Jan; 71(1):71-80.
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MKP-1 signaling events are required for early osteoclastogenesis in lineage defined progenitor populations by disrupting RANKL-induced NFATc1 nuclear translocation. Bone. 2014 Mar; 60:16-25.
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Role for Prdx1 as a specific sensor in redox-regulated senescence in breast cancer. Oncogene. 2013 Nov 07; 32(45):5302-14.
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Kaposi's sarcoma-associated herpesvirus suppression of DUSP1 facilitates cellular pathogenesis following de novo infection. J Virol. 2013 Jan; 87(1):621-35.
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MKP-1 is essential for canonical vitamin D-induced signaling through nuclear import and regulates RANKL expression and function. Mol Endocrinol. 2012 Oct; 26(10):1682-93.
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Sexual dimorphism in periapical inflammation and bone loss from mitogen-activated protein kinase phosphatase-1 deficient mice. J Endod. 2012 Aug; 38(8):1097-100.
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MKP-1 regulates cytokine mRNA stability through selectively modulation subcellular translocation of AUF1. Cytokine. 2011 Nov; 56(2):245-55.
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Anti-inflammatory effect of MAPK phosphatase-1 local gene transfer in inflammatory bone loss. Gene Ther. 2011 Apr; 18(4):344-53.
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Nitroalkenes suppress lipopolysaccharide-induced signal transducer and activator of transcription signaling in macrophages: a critical role of mitogen-activated protein kinase phosphatase 1. Endocrinology. 2008 Aug; 149(8):4086-94.