Protein Tyrosine Phosphatase, Non-Receptor Type 11
"Protein Tyrosine Phosphatase, Non-Receptor Type 11" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A subtype of non-receptor protein tyrosine phosphatases that contain two SRC HOMOLOGY DOMAINS. Mutations in the gene for protein tyrosine phosphatase, non-receptor type 11 are associated with NOONAN SYNDROME.
| Descriptor ID |
D054592
|
| MeSH Number(s) |
D08.811.277.352.650.775.300.800 D08.811.277.352.650.775.700.800 D12.644.360.585.800 D12.776.476.564.800 D12.776.476.800.800
|
| Concept/Terms |
Protein Tyrosine Phosphatase, Non-Receptor Type 11- Protein Tyrosine Phosphatase, Non-Receptor Type 11
- Protein Tyrosine Phosphatase, Non Receptor Type 11
- SHPTP2
- Phosphotyrosine Phosphatase Syp
- SHP-2 Protein-Tyrosine Phosphatase
- Protein Tyrosine Phosphatase PTP3
- Shp-2 Tyrosine Phosphatase
- Shp 2 Tyrosine Phosphatase
- Tyrosine Phosphatase, Shp-2
- SHP2 Phosphatase
- Phosphatase, SHP2
- Protein-Tyrosine-Phosphatase 2C
- Protein Tyrosine Phosphatase 2C
|
Below are MeSH descriptors whose meaning is more general than "Protein Tyrosine Phosphatase, Non-Receptor Type 11".
- Chemicals and Drugs [D]
- Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
- Hydrolases [D08.811.277]
- Esterases [D08.811.277.352]
- Phosphoric Monoester Hydrolases [D08.811.277.352.650]
- Protein Tyrosine Phosphatases [D08.811.277.352.650.775]
- Protein Tyrosine Phosphatases, Non-Receptor [D08.811.277.352.650.775.300]
- Protein Tyrosine Phosphatase, Non-Receptor Type 11 [D08.811.277.352.650.775.300.800]
- SH2 Domain-Containing Protein Tyrosine Phosphatases [D08.811.277.352.650.775.700]
- Protein Tyrosine Phosphatase, Non-Receptor Type 11 [D08.811.277.352.650.775.700.800]
- Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
- Intracellular Signaling Peptides and Proteins [D12.644.360]
- Protein Tyrosine Phosphatases, Non-Receptor [D12.644.360.585]
- Protein Tyrosine Phosphatase, Non-Receptor Type 11 [D12.644.360.585.800]
- Proteins [D12.776]
- Intracellular Signaling Peptides and Proteins [D12.776.476]
- Protein Tyrosine Phosphatases, Non-Receptor [D12.776.476.564]
- Protein Tyrosine Phosphatase, Non-Receptor Type 11 [D12.776.476.564.800]
- SH2 Domain-Containing Protein Tyrosine Phosphatases [D12.776.476.800]
- Protein Tyrosine Phosphatase, Non-Receptor Type 11 [D12.776.476.800.800]
Below are MeSH descriptors whose meaning is more specific than "Protein Tyrosine Phosphatase, Non-Receptor Type 11".
This graph shows the total number of publications written about "Protein Tyrosine Phosphatase, Non-Receptor Type 11" by people in this website by year, and whether "Protein Tyrosine Phosphatase, Non-Receptor Type 11" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 2 | 2 |
| 2002 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2012 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2016 | 2 | 0 | 2 |
| 2017 | 0 | 2 | 2 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Protein Tyrosine Phosphatase, Non-Receptor Type 11" by people in Profiles.
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Inhibition of the transcriptional kinase CDK7 overcomes therapeutic resistance in HER2-positive breast cancers. Oncogene. 2020 01; 39(1):50-63.
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Antibody blockade of CLEC12A delays EAE onset and attenuates disease severity by impairing myeloid cell CNS infiltration and restoring positive immunity. Sci Rep. 2017 06 02; 7(1):2707.
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Signaling adaptor ShcD suppresses extracellular signal-regulated kinase (Erk) phosphorylation distal to the Ret and Trk neurotrophic receptors. J Biol Chem. 2017 04 07; 292(14):5748-5759.
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Developmental SHP2 dysfunction underlies cardiac hypertrophy in Noonan syndrome with multiple lentigines. J Clin Invest. 2016 08 01; 126(8):2989-3005.
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A novel double-negative feedback loop between miR-489 and the HER2-SHP2-MAPK signaling axis regulates breast cancer cell proliferation and tumor growth. Oncotarget. 2016 Apr 05; 7(14):18295-308.
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Protein Kinase A (PKA) Phosphorylation of Shp2 Protein Inhibits Its Phosphatase Activity and Modulates Ligand Specificity. J Biol Chem. 2015 May 08; 290(19):12058-67.
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Glutathione S-transferase P influences redox and migration pathways in bone marrow. PLoS One. 2014; 9(9):e107478.
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Receptor tyrosine kinase ubiquitylation involves the dynamic regulation of Cbl-Spry2 by intersectin 1 and the Shp2 tyrosine phosphatase. Mol Cell Biol. 2014 Jan; 34(2):271-9.
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Diminished functional role and altered localization of SHP2 in non-small cell lung cancer cells with EGFR-activating mutations. Oncogene. 2013 May 02; 32(18):2346-55, 2355.e1-10.
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O-linked N-acetylglucosamine modification of insulin receptor substrate-1 occurs in close proximity to multiple SH2 domain binding motifs. Mol Cell Proteomics. 2009 Dec; 8(12):2733-45.