"Acetylcholinesterase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the hydrolysis of ACETYLCHOLINE to CHOLINE and acetate. In the CNS, this enzyme plays a role in the function of peripheral neuromuscular junctions. EC 3.1.1.7.
| Descriptor ID |
D000110
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| MeSH Number(s) |
D08.811.277.352.100.170.176
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Acetylcholinesterase".
Below are MeSH descriptors whose meaning is more specific than "Acetylcholinesterase".
This graph shows the total number of publications written about "Acetylcholinesterase" by people in this website by year, and whether "Acetylcholinesterase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 2 | 2 |
| 2004 | 2 | 0 | 2 |
| 2005 | 1 | 1 | 2 |
| 2006 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2015 | 0 | 1 | 1 |
| 2016 | 1 | 1 | 2 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Acetylcholinesterase" by people in Profiles.
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ChAT::Cre transgenic rats show sex-dependent altered fear behaviors, ultrasonic vocalizations and cholinergic marker expression. Genes Brain Behav. 2023 02; 22(1):e12837.
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Synthesis and biological evaluation of ranitidine analogs as multiple-target-directed cognitive enhancers for the treatment of Alzheimer's disease. Bioorg Med Chem Lett. 2016 11 15; 26(22):5573-5579.
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Intranasal delivery of obidoxime to the brain prevents mortality and CNS damage from organophosphate poisoning. Neurotoxicology. 2016 Mar; 53:64-73.
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Polycyclic Polyprenylated Acylphloroglucinol Congeners Possessing Diverse Structures from Hypericum henryi. J Nat Prod. 2015 Apr 24; 78(4):885-95.
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Insights and ideas garnered from marine metabolites for development of dual-function acetylcholinesterase and amyloid-? aggregation inhibitors. Mar Drugs. 2014 Apr 04; 12(4):2114-31.
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Microinjection of naltrexone into the central, but not the basolateral, amygdala blocks the anxiolytic effects of diazepam in the plus maze. Neuropsychopharmacology. 2006 Jun; 31(6):1227-40.
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Facile synthesis and PET imaging of a novel potential heart acetylcholinesterase tracer N-[11C]methyl-3-[[(dimethylamino)carbonyl]oxy]-2-(2',2'-diphenylpropionoxymethyl)pyridinium. Bioorg Med Chem Lett. 2005 Oct 15; 15(20):4510-4.
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Comparison of galantamine and donepezil for effects on nerve growth factor, cholinergic markers, and memory performance in aged rats. J Pharmacol Exp Ther. 2006 Feb; 316(2):679-94.
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Lateral hypothalamic acetylcholinesterase-immunoreactive neurons co-express either orexin or melanin concentrating hormone. Neurosci Lett. 2004 Nov 11; 370(2-3):123-6.
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Facile synthesis and initial PET imaging of novel potential heart acetylcholinesterase imaging agents [11C]pyridostigmine and its analogs. Nucl Med Biol. 2004 Oct; 31(7):957-64.