"Presenilin-2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Integral membrane protein of Golgi and endoplasmic reticulum. Its homodimer is an essential component of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PEPTIDES precursors. PSEN2 mutations cause ALZHEIMER DISEASE type 4.
| Descriptor ID |
D053766
|
| MeSH Number(s) |
D12.776.543.696.750
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Presenilin-2".
Below are MeSH descriptors whose meaning is more specific than "Presenilin-2".
This graph shows the total number of publications written about "Presenilin-2" by people in this website by year, and whether "Presenilin-2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2010 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2017 | 2 | 0 | 2 |
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Below are the most recent publications written about "Presenilin-2" by people in Profiles.
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Lower functional connectivity of default mode network in cognitively normal young adults with mutation of APP, presenilins and APOE e4. Brain Imaging Behav. 2017 Jun; 11(3):818-828.
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Different Hippocampus Functional Connectivity Patterns in Healthy Young Adults with Mutations of APP/Presenilin-1/2 and APOEe4. Mol Neurobiol. 2018 Apr; 55(4):3439-3450.
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Amyloid-beta protein clearance and degradation (ABCD) pathways and their role in Alzheimer's disease. Curr Alzheimer Res. 2015; 12(1):32-46.
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Protein aggregates and novel presenilin gene variants in idiopathic dilated cardiomyopathy. Circulation. 2010 Mar 16; 121(10):1216-26.