"Cyclin D" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cyclin subtype that is specific for CYCLIN-DEPENDENT KINASE 4 and CYCLIN-DEPENDENT KINASE 6. Unlike most cyclins, cyclin D expression is not cyclical, but rather it is expressed in response to proliferative signals. Cyclin D may therefore play a role in cellular responses to mitogenic signals.
| Descriptor ID |
D056741
|
| MeSH Number(s) |
D12.644.360.262.150 D12.776.167.218.150 D12.776.476.262.150
|
| Concept/Terms |
Cyclin D- Cyclin D
- Type D Cyclins
- Cyclins, Type D
- D Cyclins, Type
- Type D Cyclin
- Cyclin, Type D
- D Cyclin, Type
|
Below are MeSH descriptors whose meaning is more general than "Cyclin D".
Below are MeSH descriptors whose meaning is more specific than "Cyclin D".
This graph shows the total number of publications written about "Cyclin D" by people in this website by year, and whether "Cyclin D" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2008 | 0 | 2 | 2 |
| 2009 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
| 2020 | 1 | 1 | 2 |
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Below are the most recent publications written about "Cyclin D" by people in Profiles.
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MGMT-inhibitor in combination with TGF-?RI inhibitor or CDK 4/6 inhibitor increases temozolomide sensitivity in temozolomide-resistant glioblastoma cells. Clin Transl Oncol. 2021 Mar; 23(3):612-619.
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Cyclin D-CDK4/6 functions in cancer. Adv Cancer Res. 2020; 148:147-169.
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Inhibition of Rb Phosphorylation Leads to mTORC2-Mediated Activation of Akt. Mol Cell. 2016 06 16; 62(6):929-942.
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The induction of microRNA-16 in colon cancer cells by protein arginine deiminase inhibition causes a p53-dependent cell cycle arrest. PLoS One. 2013; 8(1):e53791.
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Porphyromonas gingivalis invades human trophoblasts and inhibits proliferation by inducing G1 arrest and apoptosis. Cell Microbiol. 2009 Oct; 11(10):1517-32.
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Period 2 mutation accelerates ApcMin/+ tumorigenesis. Mol Cancer Res. 2008 Nov; 6(11):1786-93.
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Down regulation of circadian clock gene Period 2 accelerates breast cancer growth by altering its daily growth rhythm. Breast Cancer Res Treat. 2009 Sep; 117(2):423-31.
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Mutations in Fbx4 inhibit dimerization of the SCF(Fbx4) ligase and contribute to cyclin D1 overexpression in human cancer. Cancer Cell. 2008 Jul 08; 14(1):68-78.
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Identification of mutations that disrupt phosphorylation-dependent nuclear export of cyclin D1. Oncogene. 2006 Oct 12; 25(47):6291-303.
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Cyclin D expression is controlled post-transcriptionally via a phosphatidylinositol 3-kinase/Akt-dependent pathway. J Biol Chem. 1998 Nov 06; 273(45):29864-72.