"Chromosome Fragile Sites" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Specific loci that show up during KARYOTYPING as a gap (an uncondensed stretch in closer views) on a CHROMATID arm after culturing cells under specific conditions. These sites are associated with an increase in CHROMOSOME FRAGILITY. They are classified as common or rare, and by the specific culture conditions under which they develop. Fragile site loci are named by the letters "FRA" followed by a designation for the specific chromosome, and a letter which refers to which fragile site of that chromosome (e.g. FRAXA refers to fragile site A on the X chromosome. It is a rare, folic acid-sensitive fragile site associated with FRAGILE X SYNDROME.)
| Descriptor ID |
D043283
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| MeSH Number(s) |
G05.360.340.024.189.610
|
| Concept/Terms |
Chromosome Fragile Sites- Chromosome Fragile Sites
- Chromosome Fragile Site
- Fragile Site, Chromosome
- Site, Chromosome Fragile
- Sites, Chromosome Fragile
- Fragile Sites, Chromosome
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Below are MeSH descriptors whose meaning is more general than "Chromosome Fragile Sites".
Below are MeSH descriptors whose meaning is more specific than "Chromosome Fragile Sites".
This graph shows the total number of publications written about "Chromosome Fragile Sites" by people in this website by year, and whether "Chromosome Fragile Sites" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 2 | 2 |
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
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Below are the most recent publications written about "Chromosome Fragile Sites" by people in Profiles.
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An FHIT tumor suppressor gene? Genes Chromosomes Cancer. 1998 Apr; 21(4):281-9.
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Chromosome 3p14 homozygous deletions and sequence analysis of FRA3B. Hum Mol Genet. 1997 Feb; 6(2):193-203.
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Integrated YAC contig containing the 3p14.2 hereditary renal carcinoma 3;8 translocation breakpoint and the fragile site FRA3B. Genes Chromosomes Cancer. 1994 Dec; 11(4):216-21.
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Multicolor FISH mapping of YAC clones in 3p14 and identification of a YAC spanning both FRA3B and the t(3;8) associated with hereditary renal cell carcinoma. Genomics. 1994 Jul 15; 22(2):319-26.
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Enhanced G2 chromatid radiosensitivity in dyskeratosis congenita fibroblasts. Am J Hum Genet. 1990 Feb; 46(2):350-7.
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Translocation t(3;8)(p14.2;q24.1) in renal cell carcinoma affects expression of the common fragile site at 3p14(FRA3B) in lymphocytes. Cancer Genet Cytogenet. 1988 Mar; 31(1):69-73.
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Loss of common 3p14 fragile site expression in renal cell carcinoma with deletion breakpoint at 3p14. Cancer Genet Cytogenet. 1988 Mar; 31(1):75-82.