"Phencyclidine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is similar to KETAMINE in structure and in many of its effects. Like ketamine, it can produce a dissociative state. It exerts its pharmacological action through inhibition of NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE). As a drug of abuse, it is known as PCP and Angel Dust.
| Descriptor ID |
D010622
|
| MeSH Number(s) |
D03.383.621.699
|
| Concept/Terms |
Phencyclidine- Phencyclidine
- 1-(1-Phenylcyclohexyl)piperidine
- Angel Dust
- Dust, Angel
|
Below are MeSH descriptors whose meaning is more general than "Phencyclidine".
Below are MeSH descriptors whose meaning is more specific than "Phencyclidine".
This graph shows the total number of publications written about "Phencyclidine" by people in this website by year, and whether "Phencyclidine" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
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Below are the most recent publications written about "Phencyclidine" by people in Profiles.
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Neuropharmacology of light-induced locomotor activation. Neuropharmacology. 2015 Aug; 95:243-51.
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The search for better noncholinergic treatment options for Alzheimer's disease. J Clin Psychiatry. 2003; 64 Suppl 9:18-22.
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Effect of central injection of phencyclidine on QNB accumulation and motor activity. Eur J Pharmacol. 1989 Jul 18; 166(2):123-9.
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Effect of dopaminergic drugs on enhancement of the binding of quinuclidinyl benzilate by phencyclidine in vivo. Neuropharmacology. 1989 Jun; 28(6):617-24.
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Effect of central administration of phencyclidine on plasma concentrations of luteinizing hormone. Brain Res. 1989 Jan 30; 478(2):382-4.
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Parametric studies on phencyclidine enhancement of 3H quinuclidinyl benzilate accumulation in vivo. Pharmacol Biochem Behav. 1988 May; 30(1):31-5.
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Discriminative properties of phencyclidine in mice: generalization to ketamine and monohydroxy metabolites. Psychopharmacology (Berl). 1988; 96(3):381-4.
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Effect of phencyclidine and two monohydroxy metabolites on 3H QNB binding in vivo in rats. Pharmacol Biochem Behav. 1987 Apr; 26(4):847-9.
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Doubtful role for phencyclidine metabolites in PCP enhancement of QNB binding. Pharmacol Biochem Behav. 1987 Apr; 26(4):671-6.
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Behavioral and biochemical stereoselectivity of sigma opiate/PCP receptors. Brain Res. 1984 Feb 27; 294(1):174-7.