"Cytochrome P-450 CYP4A" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A P450 oxidoreductase that catalyzes the hydroxylation of the terminal carbon of linear hydrocarbons such as OCTANES and FATTY ACIDS in the omega position. The enzyme may also play a role in the oxidation of a variety of structurally unrelated compounds such as XENOBIOTICS, and STEROIDS.
| Descriptor ID |
D042926
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| MeSH Number(s) |
D08.244.453.870.500 D08.811.682.690.708.170.496.500 D12.776.422.220.453.870.500
|
| Concept/Terms |
Cytochrome P-450 CYP4A- Cytochrome P-450 CYP4A
- CYP4A, Cytochrome P-450
- Cytochrome P 450 CYP4A
- P-450 CYP4A, Cytochrome
- Fatty Acid Omega-Hydroxylase
- Acid Omega-Hydroxylase, Fatty
- Fatty Acid Omega Hydroxylase
- Omega-Hydroxylase, Fatty Acid
- Omega-Hydroxylase
- Omega Hydroxylase
- Alkane 1-Monooxygenase
- Alkane 1 Monooxygenase
- CYP4A
- Cytochrome P-450 4A
- Cytochrome P 450 4A
- P-450 4A, Cytochrome
- Cytochrome P-450 IVA
- Cytochrome P 450 IVA
- Laurate Omega-Hydroxylase
- Laurate Omega Hydroxylase
- Omega-Hydroxylase, Laurate
- Lauric Acid (Omega-1)-Hydroxylase
- Lauric Acid Hydroxylase
- Acid Hydroxylase, Lauric
- Lauric Acid Omega-hydroxylase
- Acid Omega-hydroxylase, Lauric
- Lauric Acid Omega hydroxylase
- Omega-hydroxylase, Lauric Acid
- Omega-1 Hydroxylase
- Hydroxylase, Omega-1
- Omega 1 Hydroxylase
- Omega-Lauryl Hydroxylase
- Hydroxylase, Omega-Lauryl
- Omega Lauryl Hydroxylase
- Lauric Acid Monooxygenase
- Alkane 1-Hydroxylase
- Alkane 1 Hydroxylase
- Alkane Hydroxylase
- Hydroxylase, Alkane
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Below are MeSH descriptors whose meaning is more general than "Cytochrome P-450 CYP4A".
Below are MeSH descriptors whose meaning is more specific than "Cytochrome P-450 CYP4A".
This graph shows the total number of publications written about "Cytochrome P-450 CYP4A" by people in this website by year, and whether "Cytochrome P-450 CYP4A" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2013 | 2 | 0 | 2 |
| 2014 | 0 | 1 | 1 |
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Below are the most recent publications written about "Cytochrome P-450 CYP4A" by people in Profiles.
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Combined therapy with COX-2 inhibitor and 20-HETE inhibitor reduces colon tumor growth and the adverse effects of ischemic stroke associated with COX-2 inhibition. Am J Physiol Regul Integr Comp Physiol. 2014 Sep 15; 307(6):R693-703.
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20-HETE and EETs in diabetic nephropathy: a novel mechanistic pathway. PLoS One. 2013; 8(8):e70029.
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Involvement of renal cytochromes P450 and arachidonic acid metabolites in diabetic nephropathy. J Biol Regul Homeost Agents. 2013 Jul-Sep; 27(3):693-703.
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Induction of peroxisome proliferation in cultured hepatocytes by a series of halogenated acetates. Toxicology. 2004 May 03; 197(3):189-97.
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The CYP4A isoforms hydroxylate epoxyeicosatrienoic acids to form high affinity peroxisome proliferator-activated receptor ligands. J Biol Chem. 2002 Sep 20; 277(38):35105-12.
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Peroxisome proliferator-activated receptor alpha-mediated pathways are altered in hepatocyte-specific retinoid X receptor alpha-deficient mice. J Biol Chem. 2000 Sep 08; 275(36):28285-90.
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A novel murine P-450 gene, Cyp4a14, is part of a cluster of Cyp4a and Cyp4b, but not of CYP4F, genes in mouse and humans. Biochem J. 1997 Aug 01; 325 ( Pt 3):741-9.