"Giant Cells" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Multinucleated masses produced by the fusion of many cells; often associated with viral infections. In AIDS, they are induced when the envelope glycoprotein of the HIV virus binds to the CD4 antigen of uninfected neighboring T4 cells. The resulting syncytium leads to cell death and thus may account for the cytopathic effect of the virus.
| Descriptor ID |
D015726
|
| MeSH Number(s) |
A11.500
|
| Concept/Terms |
Giant Cells- Giant Cells
- Cell, Giant
- Cells, Giant
- Giant Cell
- Syncytium
- Polykaryocytes
- Polykaryocyte
- Syncytia
- Giant Cells, Multinucleated
- Cell, Multinucleated Giant
- Cells, Multinucleated Giant
- Giant Cell, Multinucleated
- Multinucleated Giant Cell
- Multinucleated Giant Cells
|
Below are MeSH descriptors whose meaning is more general than "Giant Cells".
Below are MeSH descriptors whose meaning is more specific than "Giant Cells".
This graph shows the total number of publications written about "Giant Cells" by people in this website by year, and whether "Giant Cells" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 1 | 2 | 3 |
| 2007 | 1 | 0 | 1 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2016 | 0 | 1 | 1 |
| 2022 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Giant Cells" by people in Profiles.
-
Autophagy modulating therapeutics inhibit ovarian cancer colony generation by polyploid giant cancer cells (PGCCs). BMC Cancer. 2022 Apr 14; 22(1):410.
-
Lack of Relationship Between Serum Cardiac Troponin I Level and Giant Cell Myocarditis Diagnosis and Outcomes. J Card Fail. 2016 07; 22(7):583-5.
-
Giant cell encephalitis and microglial infection with mucosally transmitted simian-human immunodeficiency virus SHIVSF162P3N in rhesus macaques. J Neurovirol. 2014 Feb; 20(1):62-72.
-
A positive feedback loop involving Gcm1 and Fzd5 directs chorionic branching morphogenesis in the placenta. PLoS Biol. 2013; 11(4):e1001536.
-
Canonical and atypical E2Fs regulate the mammalian endocycle. Nat Cell Biol. 2012 Nov; 14(11):1192-202.
-
The homologous recombination protein RAD51D mediates the processing of 6-thioguanine lesions downstream of mismatch repair. Mol Cancer Res. 2011 Feb; 9(2):206-14.
-
Intracardiac giant cells after left ventricular assist device placement. J Heart Lung Transplant. 2007 Apr; 26(4):417-20.
-
Cyclin D1 and p21 is elevated in the giant cells of giant cell tumors. J Orthop Res. 2006 Mar; 24(3):428-37.
-
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest. 2003 Dec; 112(12):1821-30.
-
Viral induced fusion and syncytium formation: measurement by the Kolmogorov-Smirnov statistical test. J Virol Methods. 2003 Aug; 111(2):157-61.