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Woster, Patrick
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overview Dr. Patrick M. Woster received a B.S. degree in Pharmacy in 1978 and a Ph.D. in medicinal chemistry in 1986, both from the University of Nebraska. He completed postdoctoral work in the laboratory of James Coward at Rensselaer Polytechnic Institute (chemistry) and the University of Michigan (medicinal chemistry), and then joined the faculty at Wayne State University as an assistant professor in 1988. He was promoted to Professor of Pharmaceutical Sciences in 2000. Dr. Woster moved to the Medical University of South Carolina in 2011, where he is Professor, Interim Chair of Drug Discovery and Biomedical Sciences and the South Carolina SmartState™ Endowed Chair in Drug Discovery (2011-present). He also serves as Director of the MUSC Drug Design and Synthesis Core. Professor Woster maintains an active research program that has been funded by NIH, WHO and the pharmaceutical industry. Ongoing projects in the Woster laboratories include the synthesis of novel inhibitors of lysine-specific demethylase 1 and histone deacetylases as epigenetic modulators, synthesis of oligoamines as antitumor, antibacterial or antimalarial agents, design and synthesis of small molecules and cyclic/stapled peptide analogues as epigenetic modulators and the synthesis of mechanism-based enzyme inactivators. Dr. Woster has directed 12 Ph.D. dissertations and 4 Master's theses, and has mentored 11 postdoctoral associates. To date, he has authored more than 120 articles in peer-reviewed research journals, 120 research abstracts and 15 patent applications. He is a frequent invited speaker, both nationally and internationally, and has organized a number of scientific conferences, including the 2009 Gordon Research Conference and Graduate Research Seminar on Polyamines, and the 34th National Medicinal Chemistry Symposium. Dr. Woster has served as a member of many NIH study sections and other grant review panels, and serves on editorial boards or as a reviewer for numerous scientific journals. He has also been an active member of American Chemical Society (ACS), and has served as an officer in the Division of Medicinal Chemistry for 21 years.
One or more keywords matched the following items that are connected to Woster, Patrick
Item TypeName
Academic Article The role of polyamine catabolism in polyamine analogue-induced programmed cell death.
Academic Article Structural specificity of polyamines and polyamine analogues in the protection of DNA from strand breaks induced by reactive oxygen species.
Academic Article Unsymmetrically substituted polyamine analogue induces caspase-independent programmed cell death in Bcl-2-overexpressing cells.
Academic Article 1-(N-alkylamino)-11-(N-ethylamino)-4,8-diazaundecanes: simple synthetic polyamine analogues that differentially alter tubulin polymerization.
Academic Article Cytotoxicity of novel unsymmetrically substituted inhibitors of polyamine biosynthesis in human cancer cells.
Academic Article Effects of the polyamine analogues N1-ethyl-N11-((cyclopropyl)methyl)-4,8-diazaundecane and N1-ethylN-11-((cycloheptyl)methyl)-4,8-diazaundecane in human prostate cancer cells.
Academic Article Clinical aspects of cell death in breast cancer: the polyamine pathway as a new target for treatment.
Academic Article Terminally alkylated polyamine analogues as chemotherapeutic agents.
Academic Article Combination of standard cytotoxic agents with polyamine analogues in the treatment of breast cancer cell lines.
Academic Article Detoxification of the polyamine analogue N1-ethyl-N11-[(cycloheptyl)methy]-4,8-diazaundecane (CHENSpm) by polyamine oxidase.
Academic Article Polyamine analogue induction of programmed cell death in human lung tumor cells.
Academic Article Induction of apoptosis in human leukaemic cells by IPENSpm, a novel polyamine analogue and anti-metabolite.
Academic Article Induction of the PAOh1/SMO polyamine oxidase by polyamine analogues in human lung carcinoma cells.
Academic Article Polyamine metabolism in a member of the phylum Microspora (Encephalitozoon cuniculi): effects of polyamine analogues.
Academic Article Induction of human spermine oxidase SMO(PAOh1) is regulated at the levels of new mRNA synthesis, mRNA stabilization and newly synthesized protein.
Academic Article Molecular basis for the polyamine-ompF porin interactions: inhibitor and mutant studies.
Academic Article Significance of targeting polyamine metabolism as an antineoplastic strategy: unique targets for polyamine analogues.
Academic Article Inhibition of lysine-specific demethylase 1 by polyamine analogues results in reexpression of aberrantly silenced genes.
Academic Article Elevated ornithine decarboxylase levels activate ataxia telangiectasia mutated-DNA damage signaling in normal keratinocytes.
Academic Article Novel alkylpolyamine analogues that possess both antitrypanosomal and antimicrosporidial activity.
Academic Article Cloning and characterization of a human polyamine oxidase that is inducible by polyamine analogue exposure.
Academic Article Spermine analogue-regulated expression of spermidine/spermine N1-acetyltransferase and its effects on depletion of intracellular polyamine pools in mouse fetal fibroblasts.
Academic Article Spermine oxidase (SMO) activity in breast tumor tissues and biochemical analysis of the anticancer spermine analogues BENSpm and CPENSpm.
Academic Article Use of polyamine derivatives as selective histone deacetylase inhibitors.
Academic Article Growth status significantly affects the response of human lung cancer cells to antitumor polyamine-analogue exposure.
Academic Article Polyamine analogs modulate gene expression by inhibiting lysine-specific demethylase 1 (LSD1) and altering chromatin structure in human breast cancer cells.
Academic Article Knockdown of ornithine decarboxylase antizyme 1 causes loss of uptake regulation leading to increased N1, N11-bis(ethyl)norspermine (BENSpm) accumulation and toxicity in NCI H157 lung cancer cells.
Academic Article Polyamine catabolism contributes to enterotoxigenic Bacteroides fragilis-induced colon tumorigenesis.
Academic Article Discovery of novel alkylated (bis)urea and (bis)thiourea polyamine analogues with potent antimalarial activities.
Academic Article Polyamines and cancer: implications for chemotherapy and chemoprevention.
Academic Article The role of polyamine catabolism in anti-tumour drug response.
Academic Article The activator-binding site of Onchocerca volvulus S-adenosylmethionine decarboxylase, a potential drug target.
Academic Article Photoaffinity labeling of a cell surface polyamine binding protein.
Academic Article Growth and biochemical effects of unsymmetrically substituted polyamine analogues in human lung tumor cells 1.
Academic Article Properties of recombinant human N1-acetylpolyamine oxidase (hPAO): potential role in determining drug sensitivity.
Academic Article Spermine oxidase SMO(PAOh1), Not N1-acetylpolyamine oxidase PAO, is the primary source of cytotoxic H2O2 in polyamine analogue-treated human breast cancer cell lines.
Academic Article Polyamine-based analogues as biochemical probes and potential therapeutics.
Academic Article Metabolism of an alkyl polyamine analog by a polyamine oxidase from the microsporidian Encephalitozoon cuniculi.
Academic Article Recent advances in the development of polyamine analogues as antitumor agents.
Academic Article Polyamine analogues targeting epigenetic gene regulation.
Academic Article Alternative spermidine biosynthetic route is critical for growth of Campylobacter jejuni and is the dominant polyamine pathway in human gut microbiota.
Academic Article Effect of S-adenosyl-1,12-diamino-3-thio-9-azadodecane, a multisubstrate adduct inhibitor of spermine synthase, on polyamine metabolism in mammalian cells.
Academic Article Novel Pt(II) and Pd(II) complexes with polyamine analogues: synthesis and vibrational analysis.
Academic Article Induction of programmed cell death in human breast cancer cells by an unsymmetrically alkylated polyamine analogue.
Academic Article Synthesis and evaluation of unsymmetrically substituted polyamine analogues as modulators of human spermidine/spermine-N1-acetyltransferase (SSAT) and as potential antitumor agents.
Academic Article Synthesis and evaluation of a polyamine phosphinate and phosphonamidate as transition-state analogue inhibitors of spermidine/spermine-N1-acetyltransferase.
Concept Biogenic Polyamines
Concept Polyamines
Academic Article Histone deacetylase inhibition overcomes drug resistance through a miRNA-dependent mechanism.
Academic Article Elevated ornithine decarboxylase activity promotes skin tumorigenesis by stimulating the recruitment of bulge stem cells but not via toxic polyamine catabolic metabolites.
Award or Honor Receipt Chair, Gordon Research Conference and Graduate Research Seminar on Polyamines
Academic Article Interrogating alkyl and arylalkylpolyamino (bis)urea and (bis)thiourea isosteres as potent antimalarial chemotypes against multiple lifecycle forms of Plasmodium falciparum parasites.
Academic Article Targeting polyamine metabolism for cancer therapy and prevention.
Academic Article Curcumin mediates polyamine metabolism and sensitizes gastrointestinal cancer cells to antitumor polyamine-targeted therapies.
Academic Article Polyamine catabolism and oxidative damage.
Academic Article Novel Synthetic Polyamines Have Potent Antimalarial Activities in vitro and in vivo by Decreasing Intracellular Spermidine and Spermine Concentrations.
Academic Article Inhibition of Polyamine Biosynthesis Using Difluoromethylornithine Acts as a Potent Immune Modulator and Displays Therapeutic Synergy With PD-1-blockade.
Academic Article The biguanide polyamine analog verlindamycin promotes differentiation in neuroblastoma via induction of antizyme.
Academic Article Identification and Characterization of Novel Small-Molecule SMOX Inhibitors.
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  • Polyamines