"Biogenic Polyamines" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Biogenic amines having more than one amine group. These are long-chain aliphatic compounds that contain multiple amino and/or imino groups. Because of the linear arrangement of positive charge on these molecules, polyamines bind electrostatically to ribosomes, DNA, and RNA.
| Descriptor ID |
D015317
|
| MeSH Number(s) |
D02.092.211.415
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Biogenic Polyamines".
Below are MeSH descriptors whose meaning is more specific than "Biogenic Polyamines".
This graph shows the total number of publications written about "Biogenic Polyamines" by people in this website by year, and whether "Biogenic Polyamines" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 1 | 0 | 1 |
| 2002 | 1 | 0 | 1 |
| 2003 | 2 | 0 | 2 |
| 2005 | 1 | 0 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
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Below are the most recent publications written about "Biogenic Polyamines" by people in Profiles.
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Recent advances in the development of polyamine analogues as antitumor agents. J Med Chem. 2009 Aug 13; 52(15):4551-73.
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Elevated ornithine decarboxylase levels activate ataxia telangiectasia mutated-DNA damage signaling in normal keratinocytes. Cancer Res. 2008 Apr 01; 68(7):2214-22.
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Significance of targeting polyamine metabolism as an antineoplastic strategy: unique targets for polyamine analogues. Proc West Pharmacol Soc. 2005; 48:24-30.
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X-linked spermine synthase gene (SMS) defect: the first polyamine deficiency syndrome. Eur J Hum Genet. 2003 Dec; 11(12):937-44.
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The role of polyamine catabolism in anti-tumour drug response. Biochem Soc Trans. 2003 Apr; 31(2):361-5.
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Effect of hindlimb suspension and clenbuterol treatment on polyamine levels in skeletal muscle. Pharmacology. 2002 Jul; 65(3):145-54.
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Structural specificity of polyamines and polyamine analogues in the protection of DNA from strand breaks induced by reactive oxygen species. Biochem Biophys Res Commun. 1998 Mar 06; 244(1):298-303.
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Eflornithine treatment in SHR: potential role of vascular polyamines and ornithine decarboxylase in hypertension. Clin Exp Hypertens. 1994 Sep; 16(5):595-610.