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Jakymiw, Andrew
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overview Our research focuses on the study of RNA silencing biology and how dysregulation of its molecular components can contribute to disease, in particular oral cancer. Moreover, our laboratory is also pursuing the study of RNA interference (RNAi)-based therapies for oral cancer. The goal of our research is to gain further insights into the molecular causes of oral cancer, identify novel biomarkers for this disease, and develop improved therapeutic strategies for treating individuals afflicted with this disease.
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Item TypeName
Academic Article The GW182 protein colocalizes with mRNA degradation associated proteins hDcp1 and hLSm4 in cytoplasmic GW bodies.
Academic Article GW182 is critical for the stability of GW bodies expressed during the cell cycle and cell proliferation.
Academic Article Formation of GW bodies is a consequence of microRNA genesis.
Academic Article The role of GW/P-bodies in RNA processing and silencing.
Academic Article AAV-mediated knockdown of phospholamban leads to improved contractility and calcium handling in cardiomyocytes.
Academic Article Overexpression of dicer as a result of reduced let-7 MicroRNA levels contributes to increased cell proliferation of oral cancer cells.
Academic Article Keratinization-associated miR-7 and miR-21 regulate tumor suppressor reversion-inducing cysteine-rich protein with kazal motifs (RECK) in oral cancer.
Academic Article Fusogenic-oligoarginine peptide-mediated delivery of siRNAs targeting the CIP2A oncogene into oral cancer cells.
Academic Article The RNA binding protein Sam68 is acetylated in tumor cell lines, and its acetylation correlates with enhanced RNA binding activity.
Academic Article Disruption of GW bodies impairs mammalian RNA interference.
Academic Article GW bodies, microRNAs and the cell cycle.
Academic Article Autoimmune targeting of key components of RNA interference.
Concept RNA
Concept RNA, Small Interfering
Concept RNA Interference
Concept RNA Stability
Concept RNA, Neoplasm
Concept RNA, Messenger
Concept RNA Processing, Post-Transcriptional
Concept DEAD-box RNA Helicases
Concept RNA-Binding Proteins
Concept RNA Transport
Academic Article Identification and characterization of Dicer1e, a Dicer1 protein variant, in oral cancer cells.
Academic Article Fusogenic-oligoarginine peptide-mediated silencing of the CIP2A oncogene suppresses oral cancer tumor growth in vivo.
Academic Article Dual peptide-mediated targeted delivery of bioactive siRNAs to oral cancer cells in vivo.
Academic Article Peptide carriers to the rescue: overcoming the barriers to siRNA delivery for cancer treatment.
Search Criteria
  • RNA