Dennis K. Watson

Title
InstitutionMedical University of South Carolina
DepartmentPathology and Laboratory Medicine
AddressP.O. Box MSC908
HO307
Hollings Cancer Center - 86 Jonathan Lucas St.
Phone843-876-2376
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    Dr. Dennis K. Watson is the Hollings Cancer Center’s Associate Director of Education & Training. He ensures the education and training structure that serves pre- and post-doctoral students as well as junior faculty within the HCC is well-structured, coordinated across multiple initiatives, effective, and promotes transdisciplinary collaborations. He is a Professor of Pathology & Laboratory Medicine and also is the leader of the Cancer Biology Division of the Molecular & Cellular Biology & Pathobiology Program in MUSC’s College of Graduate Studies. Dr. Watson has trained and mentored many young scientists pursuing cancer research who now occupy key positions in academic and industrial laboratories throughout the world.

    Dr. Watson’s research interests are in the areas of cellular and molecular biology, gene discovery, cellular differentiation and molecular oncology. His laboratory has identified and functionally characterized genes with altered expression during cancer progression. Recent studies in his laboratory have explored the role of regulatory circuitry in tumor cell interaction with the microenvironment.
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    Cancer Genes, Molecular Regulation

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ford ME, Watson DK. Preface. Adv Cancer Res. 2017; 133:ix-xi. PMID: 28052824.
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    2. Labuzzetta CJ, Antonio ML, Watson PM, Wilson RC, Laboissonniere LA, Trimarchi JM, Genc B, Ozdinler PH, Watson DK, Anderson PE. Complementary feature selection from alternative splicing events and gene expression for phenotype prediction. Bioinformatics. 2016 09 01; 32(17):i421-i429. PMID: 27587658.
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    3. Paul MR, Levitt NP, Moore DE, Watson PM, Wilson RC, Denlinger CE, Watson DK, Anderson PE. Multivariate models from RNA-Seq SNVs yield candidate molecular targets for biomarker discovery: SNV-DA. BMC Genomics. 2016 Mar 31; 17:263. PMID: 27029813.
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    4. Welch DR, Antalis TM, Burnstein K, Vona-Davis L, Jensen RA, Nakshatri H, Riegel AT, Spitz DR, Watson DK, Weiner GJ. Essential Components of Cancer Education. Cancer Res. 2015 Dec 15; 75(24):5202-5. PMID: 26627010.
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    5. McDonald LT, Russell DL, Kelly RR, Xiong Y, Motamarry A, Patel RK, Jones JA, Watson PM, Turner DP, Watson DK, Soloff AC, Findlay VJ, LaRue AC. Hematopoietic stem cell-derived cancer-associated fibroblasts are novel contributors to the pro-tumorigenic microenvironment. Neoplasia. 2015 May; 17(5):434-48. PMID: 26025666.
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    6. Liu F, Li D, Yu YY, Kang I, Cha MJ, Kim JY, Park C, Watson DK, Wang T, Choi K. Induction of hematopoietic and endothelial cell program orchestrated by ETS transcription factor ER71/ETV2. EMBO Rep. 2015 May; 16(5):654-69. PMID: 25802403.
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    7. Scheiber MN, Watson PM, Rumboldt T, Stanley C, Wilson RC, Findlay VJ, Anderson PE, Watson DK. FLI1 expression is correlated with breast cancer cellular growth, migration, and invasion and altered gene expression. Neoplasia. 2014 Oct; 16(10):801-13. PMID: 25379017.
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    8. Findlay VJ, Wang C, Nogueira LM, Hurst K, Quirk D, Ethier SP, Staveley O'Carroll KF, Watson DK, Camp ER. SNAI2 modulates colorectal cancer 5-fluorouracil sensitivity through miR145 repression. Mol Cancer Ther. 2014 Nov; 13(11):2713-26. PMID: 25249558.
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    9. Lennard Richard ML, Nowling TK, Brandon D, Watson DK, Zhang XK. Fli-1 controls transcription from the MCP-1 gene promoter, which may provide a novel mechanism for chemokine and cytokine activation. Mol Immunol. 2015 Feb; 63(2):566-73. PMID: 25108845.
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    10. Abedin MJ, Nguyen A, Jiang N, Perry CE, Shelton JM, Watson DK, Ferdous A. Fli1 acts downstream of Etv2 to govern cell survival and vascular homeostasis via positive autoregulation. Circ Res. 2014 May 23; 114(11):1690-9. PMID: 24727028.
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    11. Findlay VJ, Moretz RE, Wang C, Vaena SG, Bandurraga SG, Ashenafi M, Marshall DT, Watson DK, Camp ER. Slug expression inhibits calcitriol-mediated sensitivity to radiation in colorectal cancer. Mol Carcinog. 2014 Feb; 53 Suppl 1:E130-9. PMID: 23996472.
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    12. Suzuki E, Williams S, Sato S, Gilkeson G, Watson DK, Zhang XK. The transcription factor Fli-1 regulates monocyte, macrophage and dendritic cell development in mice. Immunology. 2013 Jul; 139(3):318-27. PMID: 23320737.
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    13. Findlay VJ, LaRue AC, Turner DP, Watson PM, Watson DK. Understanding the role of ETS-mediated gene regulation in complex biological processes. Adv Cancer Res. 2013; 119:1-61. PMID: 23870508.
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    14. Qin Z, Dai L, Defee M, Findlay VJ, Watson DK, Toole BP, Cameron J, Peruzzi F, Kirkwood K, Parsons C. Kaposi's sarcoma-associated herpesvirus suppression of DUSP1 facilitates cellular pathogenesis following de novo infection. J Virol. 2013 Jan; 87(1):621-35. PMID: 23097457.
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    15. Suzuki E, Karam E, Williams S, Watson DK, Gilkeson G, Zhang XK. Fli-1 transcription factor affects glomerulonephritis development by regulating expression of monocyte chemoattractant protein-1 in endothelial cells in the kidney. Clin Immunol. 2012 Dec; 145(3):201-8. PMID: 23108091.
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    16. Rossa C, Sommer G, Spolidorio LC, Rosenzweig SA, Watson DK, Kirkwood KL. Loss of expression and function of SOCS3 is an early event in HNSCC: altered subcellular localization as a possible mechanism involved in proliferation, migration and invasion. PLoS One. 2012; 7(9):e45197. PMID: 23028842.
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    17. Little EC, Wang C, Watson PM, Watson DK, Cole DJ, Camp ER. Novel immunocompetent murine models representing advanced local and metastatic pancreatic cancer. J Surg Res. 2012 Aug; 176(2):359-66. PMID: 22221605.
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    18. Moussa O, Ciupek A, Watson DK, Halushka PV. Urinary thromboxane B2 and thromboxane receptors in bladder cancer: opportunity for detection and monitoring. Prostaglandins Other Lipid Mediat. 2011 Nov; 96(1-4):41-4. PMID: 21983220.
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    19. Turner DP, Findlay VJ, Moussa O, Semenchenko VI, Watson PM, LaRue AC, Desouki MM, Fraig M, Watson DK. Mechanisms and functional consequences of PDEF protein expression loss during prostate cancer progression. Prostate. 2011 Dec; 71(16):1723-35. PMID: 21446014.
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    20. Camp ER, Findlay VJ, Vaena SG, Walsh J, Lewin DN, Turner DP, Watson DK. Slug expression enhances tumor formation in a noninvasive rectal cancer model. J Surg Res. 2011 Sep; 170(1):56-63. PMID: 21470622.
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    21. Findlay VJ, Turner DP, Yordy JS, McCarragher B, Shriver MR, Szalai G, Watson PM, Larue AC, Moussa O, Watson DK. Prostate-Derived ETS Factor Regulates Epithelial-to-Mesenchymal Transition through Both SLUG-Dependent and Independent Mechanisms. Genes Cancer. 2011 Feb; 2(2):120-9. PMID: 21779485.
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    22. Moussa O, LaRue AC, Abangan RS, Williams CR, Zhang XK, Masuya M, Gong YZ, Spyropoulos DD, Ogawa M, Gilkeson G, Watson DK. Thrombocytopenia in mice lacking the carboxy-terminal regulatory domain of the Ets transcription factor Fli1. Mol Cell Biol. 2010 Nov; 30(21):5194-206. PMID: 20823267.
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    23. Mathenia J, Reyes-Cortes E, Williams S, Molano I, Ruiz P, Watson DK, Gilkeson GS, Zhang XK. Impact of Fli-1 transcription factor on autoantibody and lupus nephritis in NZM2410 mice. Clin Exp Immunol. 2010 Nov; 162(2):362-71. PMID: 20731671.
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    24. Ogawa M, Larue AC, Watson PM, Watson DK. Hematopoietic stem cell origin of connective tissues. Exp Hematol. 2010 Jul; 38(7):540-7. PMID: 20412832.
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    25. Ogawa M, Larue AC, Watson PM, Watson DK. Hematopoietic stem cell origin of mesenchymal cells: opportunity for novel therapeutic approaches. Int J Hematol. 2010 Apr; 91(3):353-9. PMID: 20336396.
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    26. Asano Y, Stawski L, Hant F, Highland K, Silver R, Szalai G, Watson DK, Trojanowska M. Endothelial Fli1 deficiency impairs vascular homeostasis: a role in scleroderma vasculopathy. Am J Pathol. 2010 Apr; 176(4):1983-98. PMID: 20228226.
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    27. Schaefer JS, Sabherwal Y, Shi HY, Sriraman V, Richards J, Minella A, Turner DP, Watson DK, Zhang M. Transcriptional regulation of p21/CIP1 cell cycle inhibitor by PDEF controls cell proliferation and mammary tumor progression. J Biol Chem. 2010 Apr 09; 285(15):11258-69. PMID: 20139077.
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    28. Mathenia, J., Reyes-Cortes, E., Molano, I., Ruiz, P., Watson, D. K., Gilkeson, G. S., Zhang, X. K. Clinical and Experimental Immunology. Impact of Fli-1 transcription factor on lupus disease development in NZM2410 mice. 2010; 162:362–371.
    29. Moussa O, Turner DP, Feldman RJ, Sementchenko VI, McCarragher BD, Desouki MM, Fraig M, Watson DK. PDEF is a negative regulator of colon cancer cell growth and migration. J Cell Biochem. 2009 Dec 15; 108(6):1389-98. PMID: 19830706.
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    30. Shirai K, Sera Y, Bulkeley W, Mehrotra M, Moussa O, LaRue AC, Watson DK, Stuart RK, Lazarchick J, Ogawa M. Hematopoietic stem cell origin of human fibroblasts: cell culture studies of female recipients of gender-mismatched stem cell transplantation and patients with chronic myelogenous leukemia. Exp Hematol. 2009 Dec; 37(12):1464-71. PMID: 19786066.
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    31. Kruse EA, Loughran SJ, Baldwin TM, Josefsson EC, Ellis S, Watson DK, Nurden P, Metcalf D, Hilton DJ, Alexander WS, Kile BT. Dual requirement for the ETS transcription factors Fli-1 and Erg in hematopoietic stem cells and the megakaryocyte lineage. Proc Natl Acad Sci U S A. 2009 Aug 18; 106(33):13814-9. PMID: 19666492.
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    32. Sera Y, LaRue AC, Moussa O, Mehrotra M, Duncan JD, Williams CR, Nishimoto E, Schulte BA, Watson PM, Watson DK, Ogawa M. Hematopoietic stem cell origin of adipocytes. Exp Hematol. 2009 Sep; 37(9):1108-20, 1120.e1-4. PMID: 19576951.
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    33. Elkareh J, Periyasamy SM, Shidyak A, Vetteth S, Schroeder J, Raju V, Hariri IM, El-Okdi N, Gupta S, Fedorova L, Liu J, Fedorova OV, Kahaleh MB, Xie Z, Malhotra D, Watson DK, Bagrov AY, Shapiro JI. Marinobufagenin induces increases in procollagen expression in a process involving protein kinase C and Fli-1: implications for uremic cardiomyopathy. Am J Physiol Renal Physiol. 2009 May; 296(5):F1219-26. PMID: 19261738.
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    34. Asano Y, Markiewicz M, Kubo M, Szalai G, Watson DK, Trojanowska M. Transcription factor Fli1 regulates collagen fibrillogenesis in mouse skin. Mol Cell Biol. 2009 Jan; 29(2):425-34. PMID: 19001092.
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    35. Findlay VJ, Turner DP, Moussa O, Watson DK. MicroRNA-mediated inhibition of prostate-derived Ets factor messenger RNA translation affects prostate-derived Ets factor regulatory networks in human breast cancer. Cancer Res. 2008 Oct 15; 68(20):8499-506. PMID: 18922924.
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    36. Zhang XK, Moussa O, LaRue A, Bradshaw S, Molano I, Spyropoulos DD, Gilkeson GS, Watson DK. The transcription factor Fli-1 modulates marginal zone and follicular B cell development in mice. J Immunol. 2008 Aug 01; 181(3):1644-54. PMID: 18641300.
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    37. Turner DP, Findlay VJ, Kirven AD, Moussa O, Watson DK. Global gene expression analysis identifies PDEF transcriptional networks regulating cell migration during cancer progression. Mol Biol Cell. 2008 Sep; 19(9):3745-57. PMID: 18579687.
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    38. Moussa O, Ashton AW, Fraig M, Garrett-Mayer E, Ghoneim MA, Halushka PV, Watson DK. Novel role of thromboxane receptors beta isoform in bladder cancer pathogenesis. Cancer Res. 2008 Jun 01; 68(11):4097-104. PMID: 18519668.
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    39. Watson PM, Miller SW, Fraig M, Cole DJ, Watson DK, Boylan AM. CaSm (LSm-1) overexpression in lung cancer and mesothelioma is required for transformed phenotypes. Am J Respir Cell Mol Biol. 2008 Jun; 38(6):671-8. PMID: 18218995.
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    40. Turner DP, Watson DK. ETS transcription factors: oncogenes and tumor suppressor genes as therapeutic targets for prostate cancer. Expert Rev Anticancer Ther. 2008 Jan; 8(1):33-42. PMID: 18095881.
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    41. Moussa, O., Riker, M., Klein, J., Fraig, M., Halushka, P. V. and Watson, D. K. Oncogene. Inhibition of Thromboxane Synthase Activity Modulates Bladder Cancer Cell Responses to Chemotherapeutic Agents. 2008; 27:55-62.
    42. Turner DP, Findlay VJ, Moussa O, Watson DK. Defining ETS transcription regulatory networks and their contribution to breast cancer progression. J Cell Biochem. 2007 Oct 15; 102(3):549-59. PMID: 17661355.
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    43. Markiewicz M, Asano Y, Znoyko S, Gong Y, Watson DK, Trojanowska M. Distinct effects of gonadectomy in male and female mice on collagen fibrillogenesis in the skin. J Dermatol Sci. 2007 Sep; 47(3):217-26. PMID: 17601707.
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    44. Higuchi T, Bartel FO, Masuya M, Deguchi T, Henderson KW, Li R, Muise-Helmericks RC, Kern MJ, Watson DK, Spyropoulos DD. Thymomegaly, microsplenia, and defective homeostatic proliferation of peripheral lymphocytes in p51-Ets1 isoform-specific null mice. Mol Cell Biol. 2007 May; 27(9):3353-66. PMID: 17339335.
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    45. Turner DP, Moussa O, Sauane M, Fisher PB, Watson DK. Prostate-derived ETS factor is a mediator of metastatic potential through the inhibition of migration and invasion in breast cancer. Cancer Res. 2007 Feb 15; 67(4):1618-25. PMID: 17308102.
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    46. Moussa O, Abol-Enein H, Bissada NK, Keane T, Ghoneim MA, Watson DK. Evaluation of survivin reverse transcriptase-polymerase chain reaction for noninvasive detection of bladder cancer. J Urol. 2006 Jun; 175(6):2312-6. PMID: 16697865.
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    47. Forough R, Weylie B, Collins C, Parker JL, Zhu J, Barhoumi R, Watson DK. Transcription factor Ets-1 regulates fibroblast growth factor-1-mediated angiogenesis in vivo: role of Ets-1 in the regulation of the PI3K/AKT/MMP-1 pathway. J Vasc Res. 2006; 43(4):327-37. PMID: 16682805.
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    48. Moussa O, Yordy JS, Abol-Enein H, Sinha D, Bissada NK, Halushka PV, Ghoneim MA, Watson DK. Prognostic and functional significance of thromboxane synthase gene overexpression in invasive bladder cancer. Cancer Res. 2005 Dec 15; 65(24):11581-7. PMID: 16357168.
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    49. Yan Y, Rubinchik S, Wood AL, Gillanders WE, Dong JY, Watson DK, Cole DJ. Bystander effect contributes to the antitumor efficacy of CaSm antisense gene therapy in a preclinical model of advanced pancreatic cancer. Mol Ther. 2006 Feb; 13(2):357-65. PMID: 16226492.
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    50. Seth A, Watson DK. ETS transcription factors and their emerging roles in human cancer. Eur J Cancer. 2005 Nov; 41(16):2462-78. PMID: 16213704.
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    51. Pei H, Li C, Adereth Y, Hsu T, Watson DK, Li R. Caspase-1 is a direct target gene of ETS1 and plays a role in ETS1-induced apoptosis. Cancer Res. 2005 Aug 15; 65(16):7205-13. PMID: 16103071.
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    52. Fraser MM, Watson PM, Fraig MM, Kelley JR, Nelson PS, Boylan AM, Cole DJ, Watson DK. CaSm-mediated cellular transformation is associated with altered gene expression and messenger RNA stability. Cancer Res. 2005 Jul 15; 65(14):6228-36. PMID: 16024624.
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    53. Zhang XK, Watson DK. The FLI-1 transcription factor is a short-lived phosphoprotein in T cells. J Biochem. 2005 Mar; 137(3):297-302. PMID: 15809330.
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    54. Yan Y, Rubinchik S, Watson PM, Kelley JR, Fraser MM, Wood AL, Dong JY, Gillanders WE, Boylan AM, Watson DK, Cole DJ. Establishing a murine pancreatic cancer CaSm model: up-regulation of CaSm is required for the transformed phenotype of murine pancreatic adenocarcinoma. Mol Ther. 2005 Mar; 11(3):363-72. PMID: 15727932.
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    55. Yordy JS, Moussa O, Pei H, Chaussabel D, Li R, Watson DK. SP100 inhibits ETS1 activity in primary endothelial cells. Oncogene. 2005 Jan 27; 24(5):916-31. PMID: 15592518.
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    56. Hsouna A, Watson DK, Hsu T. Developmental expression pattern of D-ets4, the Drosophila homologue of human Pdef. Gene Expr Patterns. 2004 Dec; 5(2):285-9. PMID: 15567727.
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    57. Grund EM, Spyropoulos DD, Watson DK, Muise-Helmericks RC. Interleukins 2 and 15 regulate Ets1 expression via ERK1/2 and MNK1 in human natural killer cells. J Biol Chem. 2005 Feb 11; 280(6):4772-8. PMID: 15563472.
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    58. Zhang XK, Gallant S, Molano I, Moussa OM, Ruiz P, Spyropoulos DD, Watson DK, Gilkeson G. Decreased expression of the Ets family transcription factor Fli-1 markedly prolongs survival and significantly reduces renal disease in MRL/lpr mice. J Immunol. 2004 Nov 15; 173(10):6481-9. PMID: 15528390.
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    59. Jackers P, Szalai G, Moussa O, Watson DK. Ets-dependent regulation of target gene expression during megakaryopoiesis. J Biol Chem. 2004 Dec 10; 279(50):52183-90. PMID: 15466856.
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    60. Masuya M, Moussa O, Abe T, Deguchi T, Higuchi T, Ebihara Y, Spyropoulos DD, Watson DK, Ogawa M. Dysregulation of granulocyte, erythrocyte, and NK cell lineages in Fli-1 gene-targeted mice. Blood. 2005 Jan 01; 105(1):95-102. PMID: 15367440.
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    61. Yordy JS, Li R, Sementchenko VI, Pei H, Muise-Helmericks RC, Watson DK. SP100 expression modulates ETS1 transcriptional activity and inhibits cell invasion. Oncogene. 2004 Aug 26; 23(39):6654-65. PMID: 15247905.
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    62. Carbone GM, Napoli S, Valentini A, Cavalli F, Watson DK, Catapano CV. Triplex DNA-mediated downregulation of Ets2 expression results in growth inhibition and apoptosis in human prostate cancer cells. Nucleic Acids Res. 2004; 32(14):4358-67. PMID: 15314206.
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    63. Hsu T, Trojanowska M, Watson DK. Ets proteins in biological control and cancer. J Cell Biochem. 2004 Apr 01; 91(5):896-903. PMID: 15034925.
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    64. Moussa O, Szalai G, Abol-Enein H, Bissada NK, Ghoneim MA, Watson DK. Detection of Chromosomal Aberrations in Transitional Cell Carcinoma of the Bladder by Representational Difference Analysis. Cancer Genomics Proteomics. 2004 Jan-Feb; 1(1):9-16. PMID: 31394612.
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    65. Moussa, O., Szalai, G., Abou-Elenin, H., Bissada, N. K., Ghoneim, M. A., and Watson, D. K. Cancer Genomics and Proteomics. Detection of Chromosomal Aberrations in Transitional Cell Carcinoma of the Bladder by Representational Difference Analysis. 2004; 1:9-16.
    66. Kubo M, Czuwara-Ladykowska J, Moussa O, Markiewicz M, Smith E, Silver RM, Jablonska S, Blaszczyk M, Watson DK, Trojanowska M. Persistent down-regulation of Fli1, a suppressor of collagen transcription, in fibrotic scleroderma skin. Am J Pathol. 2003 Aug; 163(2):571-81. PMID: 12875977.
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    67. Feldman RJ, Sementchenko VI, Gayed M, Fraig MM, Watson DK. Pdef expression in human breast cancer is correlated with invasive potential and altered gene expression. Cancer Res. 2003 Aug 01; 63(15):4626-31. PMID: 12907642.
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    68. Pei H, Yordy JS, Leng Q, Zhao Q, Watson DK, Li R. EAPII interacts with ETS1 and modulates its transcriptional function. Oncogene. 2003 May 08; 22(18):2699-709. PMID: 12743594.
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    69. Feldman RJ, Sementchenko VI, Watson DK. The epithelial-specific Ets factors occupy a unique position in defining epithelial proliferation, differentiation and carcinogenesis. Anticancer Res. 2003 May-Jun; 23(3A):2125-31. PMID: 12894586.
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    70. Chen Y, Wang J, Fraig MM, Henderson K, Bissada NK, Watson DK, Schweinfest CW. Alterations in PMS2, MSH2 and MLH1 expression in human prostate cancer. Int J Oncol. 2003 May; 22(5):1033-43. PMID: 12684669.
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    71. Kelley JR, Fraser MM, Hubbard JM, Watson DK, Cole DJ. CaSm antisense gene therapy: a novel approach for the treatment of pancreatic cancer. Anticancer Res. 2003 May-Jun; 23(3A):2007-13. PMID: 12894573.
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    72. Spyropoulos DD, Bartel FO, Higuchi T, Deguchi T, Ogawa M, Watson DK. Marker-assisted study of genetic background and gene-targeted locus modifiers in lymphopoietic phenotypes. Anticancer Res. 2003 May-Jun; 23(3A):2015-26. PMID: 12894574.
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    73. Czuwara-Ladykowska J, Sementchenko VI, Watson DK, Trojanowska M. Ets1 is an effector of the transforming growth factor beta (TGF-beta ) signaling pathway and an antagonist of the profibrotic effects of TGF-beta. J Biol Chem. 2002 Jun 07; 277(23):20399-408. PMID: 11919190.
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    74. Grammatikakis N, Vultur A, Ramana CV, Siganou A, Schweinfest CW, Watson DK, Raptis L. The role of Hsp90N, a new member of the Hsp90 family, in signal transduction and neoplastic transformation. J Biol Chem. 2002 Mar 08; 277(10):8312-20. PMID: 11751906.
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    75. Kawada H, Ito T, Pharr PN, Spyropoulos DD, Watson DK, Ogawa M. Defective megakaryopoiesis and abnormal erythroid development in Fli-1 gene-targeted mice. Int J Hematol. 2001 Jun; 73(4):463-468. PMID: 11503960.
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    76. Chen Y, Wang J, Fraig MM, Metcalf J, Turner WR, Bissada NK, Watson DK, Schweinfest CW. Defects of DNA mismatch repair in human prostate cancer. Cancer Res. 2001 May 15; 61(10):4112-21. PMID: 11358834.
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    77. Czuwara, J., Shirasaki, F., Jackers, P., Watson, D.K. and Trojanowska, M. Journal of Biological Chemistry. Fli-1 inhibits collagen type I production in dermal fibroblasts via s Sp1-dependent pathway. 2001; 276:20839-48.
    78. Kawada, H., Ito, T., Pharr, P.N., Spyropoulos, D.D., Watson, D.K. and Ogawa, M. International Journal of Hematology. Defective megakaryopoiesis and abnormal erythroid development in Fli-1 gene targeted mice. 2001; 73:463-8.
    79. Sementchenko VI, Watson DK. Ets target genes: past, present and future. Oncogene. 2000 Dec 18; 19(55):6533-48. PMID: 11175369.
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    80. Li R, Pei H, Watson DK. Regulation of Ets function by protein - protein interactions. Oncogene. 2000 Dec 18; 19(55):6514-23. PMID: 11175367.
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    81. Spyropoulos DD, Pharr PN, Lavenburg KR, Jackers P, Papas TS, Ogawa M, Watson DK. Hemorrhage, impaired hematopoiesis, and lethality in mouse embryos carrying a targeted disruption of the Fli1 transcription factor. Mol Cell Biol. 2000 Aug; 20(15):5643-52. PMID: 10891501.
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    82. Kelley JR, Brown JM, Frasier MM, Baron PL, Schweinfest CW, Vournakis JN, Watson DK, Cole DJ. The cancer-associated Sm-like oncogene: a novel target for the gene therapy of pancreatic cancer. Surgery. 2000 Aug; 128(2):353-60. PMID: 10923016.
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    83. Li R, Pei H, Watson DK, Papas TS. EAP1/Daxx interacts with ETS1 and represses transcriptional activation of ETS1 target genes. Oncogene. 2000 Feb 10; 19(6):745-53. PMID: 10698492.
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    84. Raouf, A., Li, V., Kola, I., Watson, D.K. and Seth, A. Oncogene. The Ets1 proto-oncogene is upregulated by retinoic acid characterization of a functional retinoic acid response element in the Ets1 promoter. 2000; 19:1969-74.
    85. Athanasiou, M., LeGallic, L., Watson, D.K., Blair, D.G. and Mavrothalassitis, G. Cancer Gene Therapy. Suppression of the Ewing's Sarcoma phenotype by Fli-1/ERF repressor hybrids. 2000; 7:1188-95.
    86. Orr RK, Hoehn JL, Col NF. The learning curve for sentinel node biopsy in breast cancer: practical considerations. Arch Surg. 1999 Jul; 134(7):764-7. PMID: 16757682.
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    87. Orr RK, Hoehn JL, Col NF. The learning curve for sentinel node biopsy in breast cancer: practical considerations. Arch Surg. 1999 Jul; 134(7):764-7. PMID: 21917756.
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    88. Shirasaki, F., Makhluf, H.A., LeRoy, C., Watson, D.K. and Trojanowska, M. Oncogene. Ets transcription factors cooperate with Sp1 to activate human tenascin-C promoter. 1999; 18:7755-64.
    89. Sementchenko VI, Schweinfest CW, Papas TS, Watson DK. ETS2 function is required to maintain the transformed state of human prostate cancer cells. Oncogene. 1998 Dec 03; 17(22):2883-8. PMID: 9879994.
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    90. Papas TS, Bhat NK, Spyropoulos DD, Mjaatvedt AE, Vournakis J, Seth A, Watson DK. Functional relationships among ETS gene family members. Leukemia. 1997 Apr; 11 Suppl 3:557-66. PMID: 9209455.
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    91. Jorcyk CL, Garrett LJ, Maroulakou IG, Watson DK, Green JE. Multiple regulatory regions control the expression of Ets-1 in the developing mouse: vascular expression conferred by intron I. Cell Mol Biol (Noisy-le-grand). 1997 Mar; 43(2):211-25. PMID: 9130605.
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    92. Watson DK, Robinson L, Hodge DR, Kola I, Papas TS, Seth A. FLI1 and EWS-FLI1 function as ternary complex factors and ELK1 and SAP1a function as ternary and quaternary complex factors on the Egr1 promoter serum response elements. Oncogene. 1997 Jan 16; 14(2):213-21. PMID: 9010223.
      Citations:    
    93. Athanasiou M, Clausen PA, Mavrothalassitis GJ, Zhang XK, Watson DK, Blair DG. Increased expression of the ETS-related transcription factor FLI-1/ERGB correlates with and can induce the megakaryocytic phenotype. Cell Growth Differ. 1996 Nov; 7(11):1525-34. PMID: 8930402.
      Citations:    
    94. Hodge DR, Robinson L, Watson D, Lautenberger J, Zhang XK, Venanzoni M, Seth A. Interaction of ETS-1 and ERGB/FLI-1 proteins with DNA is modulated by spacing between multiple binding sites as well as phosphorylation. Oncogene. 1996 Jan 04; 12(1):11-8. PMID: 8552380.
      Citations:    
    95. Zhang XK, Papas TS, Bhat NK, Watson DK. Generation and characterization of monoclonal antibodies against the ERGB/FLI-1 transcription factor. Hybridoma. 1995 Dec; 14(6):563-9. PMID: 8770644.
      Citations:    
    96. Fisher RJ, Fivash M, Casas-Finet J, Erickson JW, Kondoh A, Bladen SV, Fisher C, Watson DK, Papas T. Real-time DNA binding measurements of the ETS1 recombinant oncoproteins reveal significant kinetic differences between the p42 and p51 isoforms. Protein Sci. 1994 Feb; 3(2):257-66. PMID: 8003962.
      Citations:    
    97. Seth A, Robinson L, Panayiotakis A, Thompson DM, Hodge DR, Zhang XK, Watson DK, Ozato K, Papas TS. The EndoA enhancer contains multiple ETS binding site repeats and is regulated by ETS proteins. Oncogene. 1994 Feb; 9(2):469-77. PMID: 7507230.
      Citations:    
    98. Seth A, Hodge DR, Thompson DM, Robinson L, Panayiotakis A, Watson DK, Papas TS. ETS family proteins activate transcription from HIV-1 long terminal repeat. AIDS Res Hum Retroviruses. 1993 Oct; 9(10):1017-23. PMID: 8280476.
      Citations:    
    99. Seth A, Robinson L, Thompson DM, Watson DK, Papas TS. Transactivation of GATA-1 promoter with ETS1, ETS2 and ERGB/Hu-FLI-1 proteins: stabilization of the ETS1 protein binding on GATA-1 promoter sequences by monoclonal antibody. Oncogene. 1993 Jul; 8(7):1783-90. PMID: 8510925.
      Citations:    
    100. Watson DK, Smyth FE, Thompson DM, Cheng JQ, Testa JR, Papas TS, Seth A. The ERGB/Fli-1 gene: isolation and characterization of a new member of the family of human ETS transcription factors. Cell Growth Differ. 1992 Oct; 3(10):705-13. PMID: 1445800.
      Citations:    
    101. Lautenberger JA, Burdett LA, Gunnell MA, Qi S, Watson DK, O'Brien SJ, Papas TS. Genomic dispersal of the ets gene family during metazoan evolution. Oncogene. 1992 Sep; 7(9):1713-9. PMID: 1501883.
      Citations:    
    102. Pribyl LJ, Watson DK, Schulz RA, Papas TS. D-elg, a member of the Drosophila ets gene family: sequence, expression and evolutionary comparison. Oncogene. 1991 Jul; 6(7):1175-83. PMID: 1713660.
      Citations:    
    103. Jorcyk CL, Watson DK, Mavrothalassitis GJ, Papas TS. The human ETS1 gene: genomic structure, promoter characterization and alternative splicing. Oncogene. 1991 Apr; 6(4):523-32. PMID: 2030910.
      Citations:    
    104. Watson DK, Mavrothalassitis GJ, Jorcyk CL, Smyth FE, Papas TS. Molecular organization and differential polyadenylation sites of the human ETS2 gene. Oncogene. 1990 Oct; 5(10):1521-7. PMID: 2250910.
      Citations:    
    105. Mavrothalassitis GJ, Watson DK, Papas TS. The human ETS-2 gene promoter: molecular dissection and nuclease hypersensitivity. Oncogene. 1990 Sep; 5(9):1337-42. PMID: 2216458.
      Citations:    
    106. Mavrothalassitis GJ, Watson DK, Papas TS. Molecular and functional characterization of the promoter of ETS2, the human c-ets-2 gene. Proc Natl Acad Sci U S A. 1990 Feb; 87(3):1047-51. PMID: 2405393.
      Citations:    
    107. Watson DK, Ascione R, Papas TS. Molecular analysis of the ets genes and their products. Crit Rev Oncog. 1990; 1(4):409-36. PMID: 1964597.
      Citations:    
    108. Papas TS, Blair DG, Watson DK, Yuan CC, Ruscetti SK, Fujiwara S, Seth AK, Fisher RJ, Bhat NK, Mavrothalassitis G, et al. The ETS family of genes: structural analysis, gene products, and involvement in neoplasia and other pathologies. Prog Clin Biol Res. 1990; 360:137-68. PMID: 2247505.
      Citations:    
    109. Papas TS, Watson DK, Sacchi N, Fujiwara S, Seth AK, Fisher RJ, Bhat NK, Mavrothalassitis G, Koizumi S, Jorcyk CL, et al. ETS family of genes in leukemia and Down syndrome. Am J Med Genet Suppl. 1990; 7:251-61. PMID: 2149958.
      Citations:    
    110. Seth A, Watson DK, Blair DG, Papas TS. c-ets-2 protooncogene has mitogenic and oncogenic activity. Proc Natl Acad Sci U S A. 1989 Oct; 86(20):7833-7. PMID: 2813360.
      Citations:    
    111. Seth A, Watson DK, Fujiwara S, Showalter SD, Papas TS. Expression of human and viral ets genes in E. coli production of human ets-2-specific monoclonal antibodies. Oncogene Res. 1989; 5(1):61-6. PMID: 2674859.
      Citations:    
    112. Watson DK, McWilliams MJ, Lapis P, Lautenberger JA, Schweinfest CW, Papas TS. Mammalian ets-1 and ets-2 genes encode highly conserved proteins. Proc Natl Acad Sci U S A. 1988 Nov; 85(21):7862-6. PMID: 2847145.
      Citations:    
    113. Watson DK, McWilliams MJ, Papas TS. A unique amino-terminal sequence predicted for the chicken proto-ets protein. Virology. 1988 Nov; 167(1):1-7. PMID: 2847407.
      Citations:    
    114. Pribyl LJ, Watson DK, McWilliams MJ, Ascione R, Papas TS. The Drosophila ets-2 gene: molecular structure, chromosomal localization, and developmental expression. Dev Biol. 1988 May; 127(1):45-53. PMID: 2834248.
      Citations:    
    115. Watson DK, McWilliams MJ, Papas TS. Molecular organization of the chicken ets locus. Virology. 1988 May; 164(1):99-105. PMID: 3284179.
      Citations:    
    116. Papas TS, Lautenberger JA, Kan NC, Watson DK, Van Beneden R, Psallidopoulos M, Fisher RJ, Fujiwara S, Samuel K, Flordellis C, et al. Viral myc genes and their cellular homologs. Gene Amplif Anal. 1986; 4:109-42. PMID: 2851528.
      Citations:    
    117. Papas TS, Watson DK, Sacchi N, O'Brien SJ, Ascione R. Molecular evolution of ets genes from avians to mammals and their cytogenetic localization to regions involved in leukemia. Gene Amplif Anal. 1986; 4:207-38. PMID: 3333359.
      Citations:    
    118. Ascione R, Sacchi N, Watson DK, Fisher RJ, Fujiwara S, Seth A, Papas TS. Oncogenes: molecular probes for clinical application in malignant diseases. Gene Amplif Anal. 1986; 4:253-77. PMID: 3333360.
      Citations:    
    119. Papas TS, Kan NC, Watson DK, Flordellis C, Lautenberger JA, Psallidopoulos MC, Rovigatti UG, Samuel KP, Ascione R, Duesberg PH. Two oncogenes in avian carcinoma virus MH2: myc and mht. Anticancer Res. 1985 Jan-Feb; 5(1):73-9. PMID: 2986522.
      Citations:    
    120. Watson DK, Psallidopoulos MC, Samuel KP, Dalla-Favera R, Papas TS. Nucleotide sequence analysis of human c-myc locus, chicken homologue, and myelocytomatosis virus MC29 transforming gene reveals a highly conserved gene product. Proc Natl Acad Sci U S A. 1983 Jun; 80(12):3642-5. PMID: 6304729.
      Citations:    
    121. Reddy EP, Reynolds RK, Watson DK, Schultz RA, Lautenberger J, Papas TS. Nucleotide sequence analysis of the proviral genome of avian myelocytomatosis virus (MC29). Proc Natl Acad Sci U S A. 1983 May; 80(9):2500-4. PMID: 6302688.
      Citations:    
    122. Watson DK, Reddy EP, Duesberg PH, Papas TS. Nucleotide sequence analysis of the chicken c-myc gene reveals homologous and unique coding regions by comparison with the transforming gene of avian myelocytomatosis virus MC29, delta gag-myc. Proc Natl Acad Sci U S A. 1983 Apr; 80(8):2146-50. PMID: 6300896.
      Citations:    
    123. Watson DK, Moudrianakis EN. Histone-dependent reconstitution and nucleosomal localization of a nonhistone chromosomal protein: the H2A-specific protease. Biochemistry. 1982 Jan 19; 21(2):248-56. PMID: 7041960.
      Citations:    
    124. Eickbush TH, Watson DK, Moudrianakis EN. A chromatin-bound proteolytic activity with unique specificity for histone H2A. Cell. 1976 Dec; 9(4 PT 2):785-92. PMID: 13934.
      Citations:    
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