Yusuf A. Hannun

Title
InstitutionMedical University of South Carolina
DepartmentBiochemistry and Molecular Biology
Address
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Bonica J, Clarke CJ, Obeid LM, Luberto C, Hannun YA. Upregulation of sphingosine kinase 1 in response to doxorubicin generates an angiogenic response via stabilization of Snail. FASEB J. 2023 03; 37(3):e22787. PMID: 36723905; PMCID: PMC9979566.
      Citations: 1     Fields:    Translation:HumansCells
    2. Greene M, Hernandez-Corbacho MJ, Ostermeyer-Fay AG, Hannun YA, Canals D. A simple, highly sensitive, and facile method to quantify ceramide at the plasma membrane. J Lipid Res. 2023 02; 64(2):100322. PMID: 36549592; PMCID: PMC9853358.
      Citations:    Fields:    Translation:Cells
    3. Yu A, Cable C, Sharma S, Shihan MH, Mattis AN, Mileva I, Hannun YA, Duwaerts CC, Chen JY. Targeting acid ceramidase ameliorates fibrosis in mouse models of non-alcoholic steatohepatitis. Front Med (Lausanne). 2022; 9:881848. PMID: 36275798; PMCID: PMC9582277.
      Citations: 1     
    4. Yi JK, Xu R, Obeid LM, Hannun YA, Airola MV, Mao C. Alkaline ceramidase catalyzes the hydrolysis of ceramides via a catalytic mechanism shared by Zn2+-dependent amidases. PLoS One. 2022; 17(9):e0271540. PMID: 36048828; PMCID: PMC9436119.
      Citations:    Fields:    Translation:HumansCells
    5. Sears SM, Dupre TV, Shah PP, Davis DL, Doll MA, Sharp CN, Vega AA, Megyesi J, Beverly LJ, Snider AJ, Obeid LM, Hannun YA, Siskind LJ, Sears SM, Dupre TV, Shah PP, Davis DL, Doll MA, Sharp CN, Vega AA, Megyesi J, Beverly LJ, Snider AJ, Obeid LM, Hannun YA, Siskind LJ. Neutral ceramidase deficiency protects against cisplatin-induced acute kidney injury. J Lipid Res. 2022 03; 63(3):100179. PMID: 35151662; PMCID: PMC8953688.
      Citations:    
    6. Hannun YA, Hannun YA. Build a registry of results that students can replicate. Nature. 2021 12; 600(7890):571. PMID: 34931036.
      Citations:    
    7. Truman JP, Ruiz CF, Montal E, Garcia-Barros M, Mileva I, Snider AJ, Hannun YA, Obeid LM, Mao C, Truman JP, Ruiz CF, Montal E, Garcia-Barros M, Mileva I, Snider AJ, Hannun YA, Obeid LM, Mao C. 1-Deoxysphinganine initiates adaptive responses to serine and glycine starvation in cancer cells via proteolysis of sphingosine kinase. J Lipid Res. 2022 01; 63(1):100154. PMID: 34838542; PMCID: PMC8953655.
      Citations:    
    8. Snider JM, You JK, Wang X, Snider AJ, Hallmark B, Zec MM, Seeds MC, Sergeant S, Johnstone L, Wang Q, Sprissler R, Carr TF, Lutrick K, Parthasarathy S, Bime C, Zhang HH, Luberto C, Kew RR, Hannun YA, Guerra S, McCall CE, Yao G, Del Poeta M, Chilton FH, Snider JM, You JK, Wang X, Snider AJ, Hallmark B, Zec MM, Seeds MC, Sergeant S, Johnstone L, Wang Q, Sprissler R, Carr TF, Lutrick K, Parthasarathy S, Bime C, Zhang HH, Luberto C, Kew RR, Hannun YA, Guerra S, McCall CE, Yao G, Del Poeta M, Chilton FH. Group IIA secreted phospholipase A2 is associated with the pathobiology leading to COVID-19 mortality. J Clin Invest. 2021 10 01; 131(19). PMID: 34428181; PMCID: PMC8483752.
      Citations:    
    9. Pothukuchi P, Agliarulo I, Pirozzi M, Rizzo R, Russo D, Turacchio G, Nüchel J, Yang JS, Gehin C, Capolupo L, Hernandez-Corbacho MJ, Biswas A, Vanacore G, Dathan N, Nitta T, Henklein P, Thattai M, Inokuchi JI, Hsu VW, Plomann M, Obeid LM, Hannun YA, Luini A, D'Angelo G, Parashuraman S, Pothukuchi P, Agliarulo I, Pirozzi M, Rizzo R, Russo D, Turacchio G, N?chel J, Yang JS, Gehin C, Capolupo L, Hernandez-Corbacho MJ, Biswas A, Vanacore G, Dathan N, Nitta T, Henklein P, Thattai M, Inokuchi JI, Hsu VW, Plomann M, Obeid LM, Hannun YA, Luini A, D'Angelo G, Parashuraman S. GRASP55 regulates intra-Golgi localization of glycosylation enzymes to control glycosphingolipid biosynthesis. EMBO J. 2021 10 18; 40(20):e107766. PMID: 34516001; PMCID: PMC8521277.
      Citations:    
    10. Mohammed S, Shamseddine AA, Newcomb B, Chavez RS, Panzner TD, Lee AH, Canals D, Okeoma CM, Clarke CJ, Hannun YA, Mohammed S, Shamseddine AA, Newcomb B, Chavez RS, Panzner TD, Lee AH, Canals D, Okeoma CM, Clarke CJ, Hannun YA. Sublethal doxorubicin promotes migration and invasion of breast cancer cells: role of Src Family non-receptor tyrosine kinases. Breast Cancer Res. 2021 07 27; 23(1):76. PMID: 34315513; PMCID: PMC8317414.
      Citations:    
    11. Velazquez FN, Viscardi V, Montemage J, Zhang L, Trocchia C, Delamont MM, Ahmad R, Hannun YA, Obeid LM, Snider AJ, Velazquez FN, Viscardi V, Montemage J, Zhang L, Trocchia C, Delamont MM, Ahmad R, Hannun YA, Obeid LM, Snider AJ. A Milk-Fat Based Diet Increases Metastasis in the MMTV-PyMT Mouse Model of Breast Cancer. Nutrients. 2021 Jul 15; 13(7). PMID: 34371939; PMCID: PMC8308868.
      Citations:    
    12. Velazquez FN, Zhang L, Viscardi V, Trocchia C, Hannun YA, Obeid LM, Snider AJ, Velazquez FN, Zhang L, Viscardi V, Trocchia C, Hannun YA, Obeid LM, Snider AJ. Loss of sphingosine kinase 1 increases lung metastases in the MMTV-PyMT mouse model of breast cancer. PLoS One. 2021; 16(5):e0252311. PMID: 34043703; PMCID: PMC8158862.
      Citations:    
    13. Sadeghi MM, Salama MF, Hannun YA, Sadeghi MM, Salama MF, Hannun YA. Protein Kinase C as a Therapeutic Target in Non-Small Cell Lung Cancer. Int J Mol Sci. 2021 May 24; 22(11). PMID: 34073823; PMCID: PMC8197251.
      Citations:    
    14. Al-Rashed F, Ahmad Z, Snider AJ, Thomas R, Kochumon S, Melhem M, Sindhu S, Obeid LM, Al-Mulla F, Hannun YA, Ahmad R, Al-Rashed F, Ahmad Z, Snider AJ, Thomas R, Kochumon S, Melhem M, Sindhu S, Obeid LM, Al-Mulla F, Hannun YA, Ahmad R. Ceramide kinase regulates TNF-a-induced immune responses in human monocytic cells. Sci Rep. 2021 04 15; 11(1):8259. PMID: 33859296; PMCID: PMC8050074.
      Citations:    
    15. Snider JM, Trayssac M, Clarke CJ, Schwartz N, Snider AJ, Obeid LM, Luberto C, Hannun YA, Snider JM, Trayssac M, Clarke CJ, Schwartz N, Snider AJ, Obeid LM, Luberto C, Hannun YA. Erratum: Multiple actions of doxorubicin on the sphingolipid network revealed by flux analysis. J Lipid Res. 2021; 62:100009. PMID: 33773486; PMCID: PMC8027766.
      Citations:    
    16. Rizzo R, Russo D, Kurokawa K, Sahu P, Lombardi B, Supino D, Zhukovsky MA, Vocat A, Pothukuchi P, Kunnathully V, Capolupo L, Boncompain G, Vitagliano C, Zito Marino F, Aquino G, Montariello D, Henklein P, Mandrich L, Botti G, Clausen H, Mandel U, Yamaji T, Hanada K, Budillon A, Perez F, Parashuraman S, Hannun YA, Nakano A, Corda D, D'Angelo G, Luini A, Rizzo R, Russo D, Kurokawa K, Sahu P, Lombardi B, Supino D, Zhukovsky MA, Vocat A, Pothukuchi P, Kunnathully V, Capolupo L, Boncompain G, Vitagliano C, Zito Marino F, Aquino G, Montariello D, Henklein P, Mandrich L, Botti G, Clausen H, Mandel U, Yamaji T, Hanada K, Budillon A, Perez F, Parashuraman S, Hannun YA, Nakano A, Corda D, D'Angelo G, Luini A. Golgi maturation-dependent glycoenzyme recycling controls glycosphingolipid biosynthesis and cell growth via GOLPH3. EMBO J. 2021 04 15; 40(8):e107238. PMID: 33749896; PMCID: PMC8047446.
      Citations:    
    17. Montfort A, Bertrand F, Rochotte J, Gilhodes J, Filleron T, Milhès J, Dufau C, Imbert C, Riond J, Tosolini M, Clarke CJ, Dufour F, Constantinescu AA, Junior NF, Garcia V, Record M, Cordelier P, Brousset P, Rochaix P, Silvente-Poirot S, Therville N, Andrieu-Abadie N, Levade T, Hannun YA, Benoist H, Meyer N, Micheau O, Colacios C, Ségui B, Montfort A, Bertrand F, Rochotte J, Gilhodes J, Filleron T, Milh?s J, Dufau C, Imbert C, Riond J, Tosolini M, Clarke CJ, Dufour F, Constantinescu AA, Junior NF, Garcia V, Record M, Cordelier P, Brousset P, Rochaix P, Silvente-Poirot S, Therville N, Andrieu-Abadie N, Levade T, Hannun YA, Benoist H, Meyer N, Micheau O, Colacios C, S?gui B. Neutral Sphingomyelinase 2 Heightens Anti-Melanoma Immune Responses and Anti-PD-1 Therapy Efficacy. Cancer Immunol Res. 2021 05; 9(5):568-582. PMID: 33727246; PMCID: PMC9631340.
      Citations:    
    18. Canals D, Salamone S, Santacreu BJ, Aguilar D, Hernandez-Corbacho MJ, Ostermeyer-Fay AG, Greene M, Nemeth E, Haley JD, Obeid LM, Hannun YA, Canals D, Salamone S, Santacreu BJ, Aguilar D, Hernandez-Corbacho MJ, Ostermeyer-Fay AG, Greene M, Nemeth E, Haley JD, Obeid LM, Hannun YA. The doxorubicin-induced cell motility network is under the control of the ceramide-activated protein phosphatase 1 alpha. FASEB J. 2021 03; 35(3):e21396. PMID: 33583073; PMCID: PMC8220868.
      Citations:    
    19. Snider JM, You JK, Wang X, Snider AJ, Hallmark B, Seeds MC, Sergeant S, Johnstone L, Wang Q, Sprissler R, Zhang HH, Luberto C, Kew RR, Hannun YA, McCall CE, Yao G, Del Poeta M, Chilton FH, Snider JM, You JK, Wang X, Snider AJ, Hallmark B, Seeds MC, Sergeant S, Johnstone L, Wang Q, Sprissler R, Zhang HH, Luberto C, Kew RR, Hannun YA, McCall CE, Yao G, Del Poeta M, Chilton FH. Group IIA Secreted Phospholipase A 2 Plays a Central Role in the Pathobiology of COVID-19. medRxiv. 2021 Feb 23. PMID: 33655264; PMCID: PMC7924289.
      Citations:    
    20. Zhu H, Klement JD, Lu C, Redd PS, Yang D, Smith AD, Poschel DB, Zou J, Liu D, Wang PG, Ostrov D, Coant N, Hannun YA, Colby AH, Grinstaff MW, Liu K, Zhu H, Klement JD, Lu C, Redd PS, Yang D, Smith AD, Poschel DB, Zou J, Liu D, Wang PG, Ostrov D, Coant N, Hannun YA, Colby AH, Grinstaff MW, Liu K. Asah2 Represses the p53-Hmox1 Axis to Protect Myeloid-Derived Suppressor Cells from Ferroptosis. J Immunol. 2021 03 15; 206(6):1395-1404. PMID: 33547170; PMCID: PMC7946776.
      Citations:    
    21. Truman JP, Ruiz CF, Trayssac M, Mao C, Hannun YA, Obeid LM, Truman JP, Ruiz CF, Trayssac M, Mao C, Hannun YA, Obeid LM. Sphingosine kinase 1 downregulation is required for adaptation to serine deprivation. FASEB J. 2021 02; 35(2):e21284. PMID: 33484475; PMCID: PMC8272629.
      Citations:    
    22. Zhang X, Sakamoto W, Canals D, Ishibashi M, Matsuda M, Nishida K, Toyoshima M, Shigeta S, Taniguchi M, Senkal CE, Okazaki T, Yaegashi N, Hannun YA, Nabe T, Kitatani K, Zhang X, Sakamoto W, Canals D, Ishibashi M, Matsuda M, Nishida K, Toyoshima M, Shigeta S, Taniguchi M, Senkal CE, Okazaki T, Yaegashi N, Hannun YA, Nabe T, Kitatani K. Ceramide synthase 2-C24:1 -ceramide axis limits the metastatic potential of ovarian cancer cells. FASEB J. 2021 02; 35(2):e21287. PMID: 33423335; PMCID: PMC8237407.
      Citations:    
    23. Bai A, Bielawski J, Bielawska A, Hannun YA, Bai A, Bielawski J, Bielawska A, Hannun YA. Synthesis of erythro- B13 enantiomers and stereospecific action of full set of B13-isomers in MCF7 breast carcinoma cells: Cellular metabolism and effects on sphingolipids. Bioorg Med Chem. 2021 02 15; 32:116011. PMID: 33461145; PMCID: PMC8190827.
      Citations:    
    24. Thayyullathil F, Cheratta AR, Alakkal A, Subburayan K, Pallichankandy S, Hannun YA, Galadari S, Thayyullathil F, Cheratta AR, Alakkal A, Subburayan K, Pallichankandy S, Hannun YA, Galadari S. Acid sphingomyelinase-dependent autophagic degradation of GPX4 is critical for the execution of ferroptosis. Cell Death Dis. 2021 01 07; 12(1):26. PMID: 33414455; PMCID: PMC7791123.
      Citations:    
    25. Trayssac M, Clarke CJ, Stith JL, Snider JM, Newen N, Gault CR, Hannun YA, Obeid LM, Trayssac M, Clarke CJ, Stith JL, Snider JM, Newen N, Gault CR, Hannun YA, Obeid LM. Targeting sphingosine kinase 1 (SK1) enhances oncogene-induced senescence through ceramide synthase 2 (CerS2)-mediated generation of very-long-chain ceramides. Cell Death Dis. 2021 01 04; 12(1):27. PMID: 33414460; PMCID: PMC7790826.
      Citations:    
    26. Velazquez FN, Hernandez-Corbacho M, Trayssac M, Stith JL, Bonica J, Jean B, Pulkoski-Gross MJ, Carroll BL, Salama MF, Hannun YA, Snider AJ, Velazquez FN, Hernandez-Corbacho M, Trayssac M, Stith JL, Bonica J, Jean B, Pulkoski-Gross MJ, Carroll BL, Salama MF, Hannun YA, Snider AJ. Bioactive sphingolipids: Advancements and contributions from the laboratory of Dr. Lina M. Obeid. Cell Signal. 2021 03; 79:109875. PMID: 33290840; PMCID: PMC8244749.
      Citations:    
    27. Xie SZ, Kaufmann KB, Wang W, Chan-Seng-Yue M, Gan OI, Laurenti E, Garcia-Prat L, Takayanagi SI, Ng SWK, Xu C, Zeng AGX, Jin L, McLeod J, Wagenblast E, Mitchell A, Kennedy JA, Liu Q, Boutzen H, Kleinau M, Jargstorf J, Holmes G, Zhang Y, Voisin V, Bader GD, Wang JCY, Hannun YA, Luberto C, Schroeder T, Minden MD, Dick JE, Xie SZ, Kaufmann KB, Wang W, Chan-Seng-Yue M, Gan OI, Laurenti E, Garcia-Prat L, Takayanagi SI, Ng SWK, Xu C, Zeng AGX, Jin L, McLeod J, Wagenblast E, Mitchell A, Kennedy JA, Liu Q, Boutzen H, Kleinau M, Jargstorf J, Holmes G, Zhang Y, Voisin V, Bader GD, Wang JCY, Hannun YA, Luberto C, Schroeder T, Minden MD, Dick JE. Sphingosine-1-phosphate receptor 3 potentiates inflammatory programs in normal and leukemia stem cells to promote differentiation. Blood Cancer Discov. 2021 01 01; 2(1):32-53. PMID: 33458693; PMCID: PMC7116590.
      Citations:    
    28. Bonica J, Mao C, Obeid LM, Hannun YA, Bonica J, Mao C, Obeid LM, Hannun YA. Transcriptional Regulation of Sphingosine Kinase 1. Cells. 2020 11 08; 9(11). PMID: 33171624; PMCID: PMC7695205.
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    29. Al-Rashed F, Ahmad Z, Thomas R, Melhem M, Snider AJ, Obeid LM, Al-Mulla F, Hannun YA, Ahmad R, Al-Rashed F, Ahmad Z, Thomas R, Melhem M, Snider AJ, Obeid LM, Al-Mulla F, Hannun YA, Ahmad R. Neutral sphingomyelinase 2 regulates inflammatory responses in monocytes/macrophages induced by TNF-a. Sci Rep. 2020 10 08; 10(1):16802. PMID: 33033337; PMCID: PMC7544688.
      Citations:    
    30. Li F, Xu R, Lin CL, Low BE, Cai L, Li S, Ji P, Huang L, Wiles MV, Hannun YA, Obeid LM, Chen Y, Mao C, Li F, Xu R, Lin CL, Low BE, Cai L, Li S, Ji P, Huang L, Wiles MV, Hannun YA, Obeid LM, Chen Y, Mao C. Maternal and fetal alkaline ceramidase 2 is required for placental vascular integrity in mice. FASEB J. 2020 11; 34(11):15252-15268. PMID: 32959379; PMCID: PMC8296754.
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    31. Alsamman S, Christenson SA, Yu A, Ayad NME, Mooring MS, Segal JM, Hu JK, Schaub JR, Ho SS, Rao V, Marlow MM, Turner SM, Sedki M, Pantano L, Ghoshal S, Ferreira DDS, Ma HY, Duwaerts CC, Espanol-Suner R, Wei L, Newcomb B, Mileva I, Canals D, Hannun YA, Chung RT, Mattis AN, Fuchs BC, Tager AM, Yimlamai D, Weaver VM, Mullen AC, Sheppard D, Chen JY, Alsamman S, Christenson SA, Yu A, Ayad NME, Mooring MS, Segal JM, Hu JK, Schaub JR, Ho SS, Rao V, Marlow MM, Turner SM, Sedki M, Pantano L, Ghoshal S, Ferreira DDS, Ma HY, Duwaerts CC, Espanol-Suner R, Wei L, Newcomb B, Mileva I, Canals D, Hannun YA, Chung RT, Mattis AN, Fuchs BC, Tager AM, Yimlamai D, Weaver VM, Mullen AC, Sheppard D, Chen JY. Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice. Sci Transl Med. 2020 08 19; 12(557). PMID: 32817366; PMCID: PMC7976849.
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    32. Otsuka Y, Airola MV, Choi YM, Coant N, Snider J, Cariello C, Saied EM, Arenz C, Bannister T, Rahaim R, Hannun YA, Shumate J, Scampavia L, Haley JD, Spicer TP, Otsuka Y, Airola MV, Choi YM, Coant N, Snider J, Cariello C, Saied EM, Arenz C, Bannister T, Rahaim R, Hannun YA, Shumate J, Scampavia L, Haley JD, Spicer TP. Identification of Small-Molecule Inhibitors of Neutral Ceramidase (nCDase) via Target-Based High-Throughput Screening. SLAS Discov. 2021 01; 26(1):113-121. PMID: 32734807; PMCID: PMC7749003.
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    33. Zhao D, Hajiaghamohseni LM, Liu X, Szulc ZM, Bai A, Bielawska A, Norris JS, Reddy SV, Hannun YA, Haque A, Zhao D, Hajiaghamohseni LM, Liu X, Szulc ZM, Bai A, Bielawska A, Norris JS, Reddy SV, Hannun YA, Haque A. Inhibition of acid ceramidase regulates MHC class II antigen presentation and suppression of autoimmune arthritis. Cytokine. 2020 11; 135:155219. PMID: 32738771; PMCID: PMC7502491.
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    34. Matmati N, Hassan BH, Ren J, Shamssedine AA, Jeong E, Shariff B, Snider J, Rødkær SV, Chen G, Mohanty BK, Zheng WJ, Obeid LM, Røssel-Larsen M, Færgeman NJ, Hannun YA, Matmati N, Hassan BH, Ren J, Shamssedine AA, Jeong E, Shariff B, Snider J, R?dk?r SV, Chen G, Mohanty BK, Zheng WJ, Obeid LM, R?ssel-Larsen M, F?rgeman NJ, Hannun YA. Yeast Sphingolipid Phospholipase Gene ISC1 Regulates the Spindle Checkpoint by a CDC55-Dependent Mechanism. Mol Cell Biol. 2020 05 28; 40(12). PMID: 32205408; PMCID: PMC7261723.
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    35. Canals D, Salamone S, Santacreu BJ, Nemeth E, Aguilar D, Hernandez-Corbacho MJ, Adada M, Staquicini DI, Arap W, Pasqualini R, Haley J, Obeid LM, Hannun YA, Canals D, Salamone S, Santacreu BJ, Nemeth E, Aguilar D, Hernandez-Corbacho MJ, Adada M, Staquicini DI, Arap W, Pasqualini R, Haley J, Obeid LM, Hannun YA. Ceramide launches an acute anti-adhesion pro-migration cell signaling program in response to chemotherapy. FASEB J. 2020 06; 34(6):7610-7630. PMID: 32307766; PMCID: PMC8265206.
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    36. Shanbhogue P, Hannun YA, Shanbhogue P, Hannun YA. Exploring the Therapeutic Landscape of Sphingomyelinases. Handb Exp Pharmacol. 2020; 259:19-47. PMID: 30478737.
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    37. Salama MF, Liu M, Clarke CJ, Espaillat MP, Haley JD, Jin T, Wang D, Obeid LM, Hannun YA, Salama MF, Liu M, Clarke CJ, Espaillat MP, Haley JD, Jin T, Wang D, Obeid LM, Hannun YA. Correction: PKCa is required for Akt-mTORC1 activation in non-small cell lung carcinoma (NSCLC) with EGFR mutation. Oncogene. 2019 Nov; 38(48):7366. PMID: 31576014.
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    38. Salama MF, Liu M, Clarke CJ, Espaillat MP, Haley JD, Jin T, Wang D, Obeid LM, Hannun YA, Salama MF, Liu M, Clarke CJ, Espaillat MP, Haley JD, Jin T, Wang D, Obeid LM, Hannun YA. PKCa is required for Akt-mTORC1 activation in non-small cell lung carcinoma (NSCLC) with EGFR mutation. Oncogene. 2019 11; 38(48):7311-7328. PMID: 31420605; PMCID: PMC6883150.
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    39. Sakamoto W, Canals D, Salamone S, Allopenna J, Clarke CJ, Snider J, Obeid LM, Hannun YA, Sakamoto W, Canals D, Salamone S, Allopenna J, Clarke CJ, Snider J, Obeid LM, Hannun YA. Probing compartment-specific sphingolipids with targeted bacterial sphingomyelinases and ceramidases. J Lipid Res. 2019 11; 60(11):1841-1850. PMID: 31243119; PMCID: PMC6824496.
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    40. Bai A, Liu X, Bielawski J, Hannun YA, Bai A, Liu X, Bielawski J, Hannun YA. Bioactive sphingolipid profile in a xenograft mouse model of head and neck squamous cell carcinoma. PLoS One. 2019; 14(4):e0215770. PMID: 31002723; PMCID: PMC6474618.
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    41. Snider JM, Luberto C, Hannun YA, Snider JM, Luberto C, Hannun YA. Approaches for probing and evaluating mammalian sphingolipid metabolism. Anal Biochem. 2019 06 15; 575:70-86. PMID: 30917945; PMCID: PMC6498843.
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    42. Shanbhogue P, Hoffmann RM, Airola MV, Maini R, Hamelin DJ, Garcia-Diaz M, Burke JE, Hannun YA, Shanbhogue P, Hoffmann RM, Airola MV, Maini R, Hamelin DJ, Garcia-Diaz M, Burke JE, Hannun YA. The juxtamembrane linker in neutral sphingomyelinase-2 functions as an intramolecular allosteric switch that activates the enzyme. J Biol Chem. 2019 05 03; 294(18):7488-7502. PMID: 30890560; PMCID: PMC6509483.
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    43. Schwartz NU, Mileva I, Gurevich M, Snider J, Hannun YA, Obeid LM, Schwartz NU, Mileva I, Gurevich M, Snider J, Hannun YA, Obeid LM. Quantifying 1-deoxydihydroceramides and 1-deoxyceramides in mouse nervous system tissue. Prostaglandins Other Lipid Mediat. 2019 04; 141:40-48. PMID: 30790665; PMCID: PMC6467697.
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    44. Choi YJ, Laclef C, Yang N, Andreu-Cervera A, Lewis J, Mao X, Li L, Snedecor ER, Takemaru KI, Qin C, Schneider-Maunoury S, Shroyer KR, Hannun YA, Koch PJ, Clark RA, Payne AS, Kowalczyk AP, Chen J, Choi YJ, Laclef C, Yang N, Andreu-Cervera A, Lewis J, Mao X, Li L, Snedecor ER, Takemaru KI, Qin C, Schneider-Maunoury S, Shroyer KR, Hannun YA, Koch PJ, Clark RA, Payne AS, Kowalczyk AP, Chen J. RPGRIP1L is required for stabilizing epidermal keratinocyte adhesion through regulating desmoglein endocytosis. PLoS Genet. 2019 01; 15(1):e1007914. PMID: 30689641; PMCID: PMC6366717.
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    45. Sahu SK, Hannun YA, Yao N, Sahu SK, Hannun YA, Yao N. Emergence of membrane sphingolipids as a potential therapeutic target. Biochimie. 2019 Mar; 158:257-264. PMID: 30703477.
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    46. Orr RK, Hoehn JL, Col NF, Snider JM, Trayssac M, Clarke CJ, Schwartz N, Snider AJ, Obeid LM, Luberto C, Hannun YA. Multiple actions of doxorubicin on the sphingolipid network revealed by flux analysis. J Lipid Res. 2019 04; 60(4):819-831. PMID: 30573560; PMCID: PMC6446699.
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    47. Bai A, Bielawska A, Rahmaniyan M, Kraveka JM, Bielawski J, Hannun YA, Bai A, Bielawska A, Rahmaniyan M, Kraveka JM, Bielawski J, Hannun YA. Dose dependent actions of LCL521 on acid ceramidase and key sphingolipid metabolites. Bioorg Med Chem. 2018 12 15; 26(23-24):6067-6075. PMID: 30448190; PMCID: PMC6323005.
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    48. Coant N, Hannun YA, Coant N, Hannun YA. Neutral ceramidase: Advances in mechanisms, cell regulation, and roles in cancer. Adv Biol Regul. 2019 01; 71:141-146. PMID: 30389354; PMCID: PMC6347532.
      Citations:    
    49. Hannun YA, Obeid LM, Hannun YA, Obeid LM. Author Correction: Sphingolipids and their metabolism in physiology and disease. Nat Rev Mol Cell Biol. 2018 Oct; 19(10):673. PMID: 30111875.
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    108. Adada MM, Canals D, Jeong N, Kelkar AD, Hernandez-Corbacho M, Pulkoski-Gross MJ, Donaldson JC, Hannun YA, Obeid LM, Adada MM, Canals D, Jeong N, Kelkar AD, Hernandez-Corbacho M, Pulkoski-Gross MJ, Donaldson JC, Hannun YA, Obeid LM. Intracellular sphingosine kinase 2-derived sphingosine-1-phosphate mediates epidermal growth factor-induced ezrin-radixin-moesin phosphorylation and cancer cell invasion. FASEB J. 2015 Nov; 29(11):4654-69. PMID: 26209696; PMCID: PMC4608912.
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    109. Airola MV, Allen WJ, Pulkoski-Gross MJ, Obeid LM, Rizzo RC, Hannun YA, Airola MV, Allen WJ, Pulkoski-Gross MJ, Obeid LM, Rizzo RC, Hannun YA. Structural Basis for Ceramide Recognition and Hydrolysis by Human Neutral Ceramidase. Structure. 2015 Aug 04; 23(8):1482-1491. PMID: 26190575; PMCID: PMC4830088.
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    110. Wu BX, Fan J, Boyer NP, Jenkins RW, Koutalos Y, Hannun YA, Crosson CE, Wu BX, Fan J, Boyer NP, Jenkins RW, Koutalos Y, Hannun YA, Crosson CE. Lack of Acid Sphingomyelinase Induces Age-Related Retinal Degeneration. PLoS One. 2015; 10(7):e0133032. PMID: 26168297; PMCID: PMC4500403.
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    111. Ghaleb AM, Bialkowska AB, Snider AJ, Gnatenko DV, Hannun YA, Yang VW, Schmidt VA, Ghaleb AM, Bialkowska AB, Snider AJ, Gnatenko DV, Hannun YA, Yang VW, Schmidt VA. IQ Motif-Containing GTPase-Activating Protein 2 (IQGAP2) Is a Novel Regulator of Colonic Inflammation in Mice. PLoS One. 2015; 10(6):e0129314. PMID: 26047140; PMCID: PMC4457730.
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    112. Hannun YA, Newcomb B, Hannun YA, Newcomb B. A new twist to the emerging functions of ceramides in cancer: novel role for platelet acid sphingomyelinase in cancer metastasis. EMBO Mol Med. 2015 Jun; 7(6):692-4. PMID: 25859016; PMCID: PMC4459812.
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    113. Salama MF, Carroll B, Adada M, Pulkoski-Gross M, Hannun YA, Obeid LM, Salama MF, Carroll B, Adada M, Pulkoski-Gross M, Hannun YA, Obeid LM. A novel role of sphingosine kinase-1 in the invasion and angiogenesis of VHL mutant clear cell renal cell carcinoma. FASEB J. 2015 Jul; 29(7):2803-13. PMID: 25805832; PMCID: PMC4478804.
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    114. Lu Z, Li Y, Jin J, Zhang X, Hannun YA, Huang Y, Lu Z, Li Y, Jin J, Zhang X, Hannun YA, Huang Y. GPR40/FFA1 and neutral sphingomyelinase are involved in palmitate-boosted inflammatory response of microvascular endothelial cells to LPS. Atherosclerosis. 2015 May; 240(1):163-73. PMID: 25795558; PMCID: PMC4397186.
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    115. Rajagopalan V, Canals D, Luberto C, Snider J, Voelkel-Johnson C, Obeid LM, Hannun YA, Rajagopalan V, Canals D, Luberto C, Snider J, Voelkel-Johnson C, Obeid LM, Hannun YA. Critical determinants of mitochondria-associated neutral sphingomyelinase (MA-nSMase) for mitochondrial localization. Biochim Biophys Acta. 2015 Apr; 1850(4):628-39. PMID: 25484313; PMCID: PMC4435939.
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    116. Snider AJ, Ali WH, Sticca JA, Coant N, Ghaleb AM, Kawamori T, Yang VW, Hannun YA, Obeid LM, Snider AJ, Ali WH, Sticca JA, Coant N, Ghaleb AM, Kawamori T, Yang VW, Hannun YA, Obeid LM. Distinct roles for hematopoietic and extra-hematopoietic sphingosine kinase-1 in inflammatory bowel disease. PLoS One. 2014; 9(12):e113998. PMID: 25460165; PMCID: PMC4252067.
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    117. Rachidi S, Sun S, Wu BX, Jones E, Drake RR, Ogretmen B, Cowart LA, Clarke CJ, Hannun YA, Chiosis G, Liu B, Li Z, Rachidi S, Sun S, Wu BX, Jones E, Drake RR, Ogretmen B, Cowart LA, Clarke CJ, Hannun YA, Chiosis G, Liu B, Li Z. Endoplasmic reticulum heat shock protein gp96 maintains liver homeostasis and promotes hepatocellular carcinogenesis. J Hepatol. 2015 Apr; 62(4):879-88. PMID: 25463537; PMCID: PMC4369194.
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    118. Shamseddine AA, Airola MV, Hannun YA, Shamseddine AA, Airola MV, Hannun YA. Roles and regulation of neutral sphingomyelinase-2 in cellular and pathological processes. Adv Biol Regul. 2015 Jan; 57:24-41. PMID: 25465297; PMCID: PMC4684640.
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    119. Bai A, Szulc ZM, Bielawski J, Pierce JS, Rembiesa B, Terzieva S, Mao C, Xu R, Wu B, Clarke CJ, Newcomb B, Liu X, Norris J, Hannun YA, Bielawska A, Bai A, Szulc ZM, Bielawski J, Pierce JS, Rembiesa B, Terzieva S, Mao C, Xu R, Wu B, Clarke CJ, Newcomb B, Liu X, Norris J, Hannun YA, Bielawska A. Targeting (cellular) lysosomal acid ceramidase by B13: design, synthesis and evaluation of novel DMG-B13 ester prodrugs. Bioorg Med Chem. 2014 Dec 15; 22(24):6933-44. PMID: 25456083; PMCID: PMC4443482.
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    120. Robinson KA, Hegyi K, Hannun YA, Buse MG, Sethi JK, Robinson KA, Hegyi K, Hannun YA, Buse MG, Sethi JK. Go-6976 reverses hyperglycemia-induced insulin resistance independently of cPKC inhibition in adipocytes. PLoS One. 2014; 9(10):e108963. PMID: 25330241; PMCID: PMC4198081.
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    121. Airola MV, Tumolo JM, Snider J, Hannun YA, Airola MV, Tumolo JM, Snider J, Hannun YA. Identification and biochemical characterization of an acid sphingomyelinase-like protein from the bacterial plant pathogen Ralstonia solanacearum that hydrolyzes ATP to AMP but not sphingomyelin to ceramide. PLoS One. 2014; 9(8):e105830. PMID: 25144372; PMCID: PMC4140839.
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    122. Jones EE, Dworski S, Canals D, Casas J, Fabrias G, Schoenling D, Levade T, Denlinger C, Hannun YA, Medin JA, Drake RR, Jones EE, Dworski S, Canals D, Casas J, Fabrias G, Schoenling D, Levade T, Denlinger C, Hannun YA, Medin JA, Drake RR. On-tissue localization of ceramides and other sphingolipids by MALDI mass spectrometry imaging. Anal Chem. 2014 Aug 19; 86(16):8303-11. PMID: 25072097; PMCID: PMC4139181.
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    123. Qin T, Matmati N, Tsoi LC, Mohanty BK, Gao N, Tang J, Lawson AB, Hannun YA, Zheng WJ, Qin T, Matmati N, Tsoi LC, Mohanty BK, Gao N, Tang J, Lawson AB, Hannun YA, Zheng WJ. Finding pathway-modulating genes from a novel Ontology Fingerprint-derived gene network. Nucleic Acids Res. 2014 Oct; 42(18):e138. PMID: 25063300; PMCID: PMC4191379.
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    124. Spincemaille P, Matmati N, Hannun YA, Cammue BP, Thevissen K, Spincemaille P, Matmati N, Hannun YA, Cammue BP, Thevissen K. Sphingolipids and mitochondrial function in budding yeast. Biochim Biophys Acta. 2014 Oct; 1840(10):3131-7. PMID: 24973565; PMCID: PMC4145010.
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    125. Perry DM, Newcomb B, Adada M, Wu BX, Roddy P, Kitatani K, Siskind L, Obeid LM, Hannun YA, Perry DM, Newcomb B, Adada M, Wu BX, Roddy P, Kitatani K, Siskind L, Obeid LM, Hannun YA. Defining a role for acid sphingomyelinase in the p38/interleukin-6 pathway. J Biol Chem. 2014 Aug 08; 289(32):22401-12. PMID: 24951586; PMCID: PMC4139247.
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    126. Korbelik M, Banáth J, Sun J, Canals D, Hannun YA, Separovic D, Korbelik M, Ban?th J, Sun J, Canals D, Hannun YA, Separovic D. Ceramide and sphingosine-1-phosphate act as photodynamic therapy-elicited damage-associated molecular patterns: cell surface exposure. Int Immunopharmacol. 2014 Jun; 20(2):359-65. PMID: 24713544; PMCID: PMC4043304.
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    127. Novgorodov SA, Riley CL, Yu J, Borg KT, Hannun YA, Proia RL, Kindy MS, Gudz TI, Novgorodov SA, Riley CL, Yu J, Borg KT, Hannun YA, Proia RL, Kindy MS, Gudz TI. Essential roles of neutral ceramidase and sphingosine in mitochondrial dysfunction due to traumatic brain injury. J Biol Chem. 2014 May 09; 289(19):13142-54. PMID: 24659784; PMCID: PMC4036326.
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    128. Wei J, Ferron M, Clarke CJ, Hannun YA, Jiang H, Blaner WS, Karsenty G, Wei J, Ferron M, Clarke CJ, Hannun YA, Jiang H, Blaner WS, Karsenty G. Bone-specific insulin resistance disrupts whole-body glucose homeostasis via decreased osteocalcin activation. J Clin Invest. 2014 Apr; 124(4):1-13. PMID: 24642469; PMCID: PMC3973090.
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    129. Spincemaille P, Chandhok G, Newcomb B, Verbeek J, Vriens K, Zibert A, Schmidt H, Hannun YA, van Pelt J, Cassiman D, Cammue BPA, Thevissen K, Spincemaille P, Chandhok G, Newcomb B, Verbeek J, Vriens K, Zibert A, Schmidt H, Hannun YA, van Pelt J, Cassiman D, Cammue BPA, Thevissen K. The plant decapeptide OSIP108 prevents copper-induced apoptosis in yeast and human cells. Biochim Biophys Acta. 2014 Jun; 1843(6):1207-1215. PMID: 24632503; PMCID: PMC4045106.
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    130. Truman JP, García-Barros M, Obeid LM, Hannun YA, Truman JP, Garc?a-Barros M, Obeid LM, Hannun YA. Evolving concepts in cancer therapy through targeting sphingolipid metabolism. Biochim Biophys Acta. 2014 Aug; 1841(8):1174-88. PMID: 24384461; PMCID: PMC4221100.
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    131. Vilaça R, Silva E, Nadais A, Teixeira V, Matmati N, Gaifem J, Hannun YA, Sá Miranda MC, Costa V, Vila?a R, Silva E, Nadais A, Teixeira V, Matmati N, Gaifem J, Hannun YA, S? Miranda MC, Costa V. Sphingolipid signalling mediates mitochondrial dysfunctions and reduced chronological lifespan in the yeast model of Niemann-Pick type C1. Mol Microbiol. 2014 Feb; 91(3):438-51. PMID: 24286211; PMCID: PMC3954977.
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    132. Liu M, Idkowiak-Baldys J, Roddy PL, Baldys A, Raymond J, Clarke CJ, Hannun YA, Liu M, Idkowiak-Baldys J, Roddy PL, Baldys A, Raymond J, Clarke CJ, Hannun YA. Sustained activation of protein kinase C induces delayed phosphorylation and regulates the fate of epidermal growth factor receptor. PLoS One. 2013; 8(11):e80721. PMID: 24244711; PMCID: PMC3823608.
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    133. Montefusco DJ, Matmati N, Hannun YA, Montefusco DJ, Matmati N, Hannun YA. The yeast sphingolipid signaling landscape. Chem Phys Lipids. 2014 Jan; 177:26-40. PMID: 24220500; PMCID: PMC4211598.
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    134. Swinnen E, Wilms T, Idkowiak-Baldys J, Smets B, De Snijder P, Accardo S, Ghillebert R, Thevissen K, Cammue B, De Vos D, Bielawski J, Hannun YA, Winderickx J, Swinnen E, Wilms T, Idkowiak-Baldys J, Smets B, De Snijder P, Accardo S, Ghillebert R, Thevissen K, Cammue B, De Vos D, Bielawski J, Hannun YA, Winderickx J. The protein kinase Sch9 is a key regulator of sphingolipid metabolism in Saccharomyces cerevisiae. Mol Biol Cell. 2014 Jan; 25(1):196-211. PMID: 24196832; PMCID: PMC3873890.
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    135. Montefusco DJ, Chen L, Matmati N, Lu S, Newcomb B, Cooper GF, Hannun YA, Lu X, Montefusco DJ, Chen L, Matmati N, Lu S, Newcomb B, Cooper GF, Hannun YA, Lu X. Distinct signaling roles of ceramide species in yeast revealed through systematic perturbation and systems biology analyses. Sci Signal. 2013 Oct 29; 6(299):rs14. PMID: 24170935; PMCID: PMC3974757.
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    136. El Osta M, Liu M, Adada M, Senkal CE, Idkowiak-Baldys J, Obeid LM, Clarke CJ, Hannun YA, El Osta M, Liu M, Adada M, Senkal CE, Idkowiak-Baldys J, Obeid LM, Clarke CJ, Hannun YA. Sustained PKC?II activity confers oncogenic properties in a phospholipase D- and mTOR-dependent manner. FASEB J. 2014 Jan; 28(1):495-505. PMID: 24121461; PMCID: PMC3868841.
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    137. García-Barros M, Coant N, Truman JP, Snider AJ, Hannun YA, Garc?a-Barros M, Coant N, Truman JP, Snider AJ, Hannun YA. Sphingolipids in colon cancer. Biochim Biophys Acta. 2014 May; 1841(5):773-82. PMID: 24060581; PMCID: PMC3962523.
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    138. Jenkins RW, Clarke CJ, Lucas JT, Shabbir M, Wu BX, Simbari F, Mueller J, Hannun YA, Lazarchick J, Shirai K, Jenkins RW, Clarke CJ, Lucas JT, Shabbir M, Wu BX, Simbari F, Mueller J, Hannun YA, Lazarchick J, Shirai K. Evaluation of the role of secretory sphingomyelinase and bioactive sphingolipids as biomarkers in hemophagocytic lymphohistiocytosis. Am J Hematol. 2013 Nov; 88(11):E265-72. PMID: 23828274; PMCID: PMC4348111.
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    139. Adada M, Canals D, Hannun YA, Obeid LM, Adada M, Canals D, Hannun YA, Obeid LM. Sphingosine-1-phosphate receptor 2. FEBS J. 2013 Dec; 280(24):6354-66. PMID: 23879641; PMCID: PMC4349199.
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    140. Adada MM, Orr-Gandy KA, Snider AJ, Canals D, Hannun YA, Obeid LM, Clarke CJ, Adada MM, Orr-Gandy KA, Snider AJ, Canals D, Hannun YA, Obeid LM, Clarke CJ. Sphingosine kinase 1 regulates tumor necrosis factor-mediated RANTES induction through p38 mitogen-activated protein kinase but independently of nuclear factor ?B activation. J Biol Chem. 2013 Sep 20; 288(38):27667-27679. PMID: 23935096; PMCID: PMC3779762.
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    141. Jin J, Zhang X, Lu Z, Perry DM, Li Y, Russo SB, Cowart LA, Hannun YA, Huang Y, Jin J, Zhang X, Lu Z, Perry DM, Li Y, Russo SB, Cowart LA, Hannun YA, Huang Y. Acid sphingomyelinase plays a key role in palmitic acid-amplified inflammatory signaling triggered by lipopolysaccharide at low concentrations in macrophages. Am J Physiol Endocrinol Metab. 2013 Oct 01; 305(7):E853-67. PMID: 23921144; PMCID: PMC3798699.
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    142. Adada M, Canals D, Hannun YA, Obeid LM, Adada M, Canals D, Hannun YA, Obeid LM. Sphingolipid regulation of ezrin, radixin, and moesin proteins family: implications for cell dynamics. Biochim Biophys Acta. 2014 May; 1841(5):727-37. PMID: 23850862; PMCID: PMC3888837.
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    143. Chen PW, Fonseca LL, Hannun YA, Voit EO, Chen PW, Fonseca LL, Hannun YA, Voit EO. Coordination of rapid sphingolipid responses to heat stress in yeast. PLoS Comput Biol. 2013; 9(5):e1003078. PMID: 23737740; PMCID: PMC3667767.
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    144. Kajimura D, Lee HW, Riley KJ, Arteaga-Solis E, Ferron M, Zhou B, Clarke CJ, Hannun YA, DePinho RA, Guo XE, Mann JJ, Karsenty G, Kajimura D, Lee HW, Riley KJ, Arteaga-Solis E, Ferron M, Zhou B, Clarke CJ, Hannun YA, DePinho RA, Guo XE, Mann JJ, Karsenty G. Adiponectin regulates bone mass via opposite central and peripheral mechanisms through FoxO1. Cell Metab. 2013 Jun 04; 17(6):901-915. PMID: 23684624; PMCID: PMC3679303.
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    145. Cinq-Frais C, Coatrieux C, Grazide MH, Hannun YA, Nègre-Salvayre A, Salvayre R, Augé N, Cinq-Frais C, Coatrieux C, Grazide MH, Hannun YA, N?gre-Salvayre A, Salvayre R, Aug? N. A signaling cascade mediated by ceramide, src and PDGFR? coordinates the activation of the redox-sensitive neutral sphingomyelinase-2 and sphingosine kinase-1. Biochim Biophys Acta. 2013 Aug; 1831(8):1344-56. PMID: 23651497.
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    146. Orr Gandy KA, Adada M, Canals D, Carroll B, Roddy P, Hannun YA, Obeid LM, Orr Gandy KA, Adada M, Canals D, Carroll B, Roddy P, Hannun YA, Obeid LM. Epidermal growth factor-induced cellular invasion requires sphingosine-1-phosphate/sphingosine-1-phosphate 2 receptor-mediated ezrin activation. FASEB J. 2013 Aug; 27(8):3155-66. PMID: 23629860; PMCID: PMC3714586.
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    147. Matmati N, Metelli A, Tripathi K, Yan S, Mohanty BK, Hannun YA, Matmati N, Metelli A, Tripathi K, Yan S, Mohanty BK, Hannun YA. Identification of C18:1-phytoceramide as the candidate lipid mediator for hydroxyurea resistance in yeast. J Biol Chem. 2013 Jun 14; 288(24):17272-84. PMID: 23620586; PMCID: PMC3682531.
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    148. Gandy KA, Canals D, Adada M, Wada M, Roddy P, Snider AJ, Hannun YA, Obeid LM, Gandy KA, Canals D, Adada M, Wada M, Roddy P, Snider AJ, Hannun YA, Obeid LM. Sphingosine 1-phosphate induces filopodia formation through S1PR2 activation of ERM proteins. Biochem J. 2013 Feb 01; 449(3):661-72. PMID: 23106337; PMCID: PMC3623934.
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    149. Airola MV, Hannun YA, Airola MV, Hannun YA. Sphingolipid metabolism and neutral sphingomyelinases. Handb Exp Pharmacol. 2013; (215):57-76. PMID: 23579449; PMCID: PMC4043343.
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    150. Canals D, Hannun YA, Canals D, Hannun YA. Novel chemotherapeutic drugs in sphingolipid cancer research. Handb Exp Pharmacol. 2013; (215):211-38. PMID: 23579458; PMCID: PMC3998523.
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    151. Rego A, Costa M, Chaves SR, Matmati N, Pereira H, Sousa MJ, Moradas-Ferreira P, Hannun YA, Costa V, Côrte-Real M, Rego A, Costa M, Chaves SR, Matmati N, Pereira H, Sousa MJ, Moradas-Ferreira P, Hannun YA, Costa V, C?rte-Real M. Modulation of mitochondrial outer membrane permeabilization and apoptosis by ceramide metabolism. PLoS One. 2012; 7(11):e48571. PMID: 23226203; PMCID: PMC3511487.
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    152. Furuya H, Wada M, Shimizu Y, Yamada PM, Hannun YA, Obeid LM, Kawamori T, Furuya H, Wada M, Shimizu Y, Yamada PM, Hannun YA, Obeid LM, Kawamori T. Effect of sphingosine kinase 1 inhibition on blood pressure. FASEB J. 2013 Feb; 27(2):656-64. PMID: 23109673; PMCID: PMC3545530.
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    153. Snider AJ, Wu BX, Jenkins RW, Sticca JA, Kawamori T, Hannun YA, Obeid LM, Snider AJ, Wu BX, Jenkins RW, Sticca JA, Kawamori T, Hannun YA, Obeid LM. Loss of neutral ceramidase increases inflammation in a mouse model of inflammatory bowel disease. Prostaglandins Other Lipid Mediat. 2012 Dec; 99(3-4):124-30. PMID: 22940715; PMCID: PMC3661865.
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    154. Salegio EA, Samaranch L, Jenkins RW, Clarke CJ, Lamarre C, Beyer J, Kells AP, Bringas J, Sebastian WS, Richardson RM, Rosenbluth KH, Hannun YA, Bankiewicz KS, Forsayeth J, Salegio EA, Samaranch L, Jenkins RW, Clarke CJ, Lamarre C, Beyer J, Kells AP, Bringas J, Sebastian WS, Richardson RM, Rosenbluth KH, Hannun YA, Bankiewicz KS, Forsayeth J. Safety study of adeno-associated virus serotype 2-mediated human acid sphingomyelinase expression in the nonhuman primate brain. Hum Gene Ther. 2012 Aug; 23(8):891-902. PMID: 22574943; PMCID: PMC3413900.
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    155. Gault CR, Eblen ST, Neumann CA, Hannun YA, Obeid LM, Gault CR, Eblen ST, Neumann CA, Hannun YA, Obeid LM. Oncogenic K-Ras regulates bioactive sphingolipids in a sphingosine kinase 1-dependent manner. J Biol Chem. 2012 Sep 14; 287(38):31794-803. PMID: 22833671; PMCID: PMC3442513.
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    156. Sewell GW, Hannun YA, Han X, Koster G, Bielawski J, Goss V, Smith PJ, Rahman FZ, Vega R, Bloom SL, Walker AP, Postle AD, Segal AW, Sewell GW, Hannun YA, Han X, Koster G, Bielawski J, Goss V, Smith PJ, Rahman FZ, Vega R, Bloom SL, Walker AP, Postle AD, Segal AW. Lipidomic profiling in Crohn's disease: abnormalities in phosphatidylinositols, with preservation of ceramide, phosphatidylcholine and phosphatidylserine composition. Int J Biochem Cell Biol. 2012 Nov; 44(11):1839-46. PMID: 22728312; PMCID: PMC3778899.
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    157. Perry DM, Kitatani K, Roddy P, El-Osta M, Hannun YA, Perry DM, Kitatani K, Roddy P, El-Osta M, Hannun YA. Identification and characterization of protein phosphatase 2C activation by ceramide. J Lipid Res. 2012 Aug; 53(8):1513-21. PMID: 22615346; PMCID: PMC3540846.
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    158. Truman JP, Al Gadban MM, Smith KJ, Jenkins RW, Mayroo N, Virella G, Lopes-Virella MF, Bielawska A, Hannun YA, Hammad SM, Truman JP, Al Gadban MM, Smith KJ, Jenkins RW, Mayroo N, Virella G, Lopes-Virella MF, Bielawska A, Hannun YA, Hammad SM. Differential regulation of acid sphingomyelinase in macrophages stimulated with oxidized low-density lipoprotein (LDL) and oxidized LDL immune complexes: role in phagocytosis and cytokine release. Immunology. 2012 May; 136(1):30-45. PMID: 22236141; PMCID: PMC3372755.
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    159. Meyers-Needham M, Lewis JA, Gencer S, Sentelle RD, Saddoughi SA, Clarke CJ, Hannun YA, Norell H, da Palma TM, Nishimura M, Kraveka JM, Khavandgar Z, Murshed M, Cevik MO, Ogretmen B, Meyers-Needham M, Lewis JA, Gencer S, Sentelle RD, Saddoughi SA, Clarke CJ, Hannun YA, Norell H, da Palma TM, Nishimura M, Kraveka JM, Khavandgar Z, Murshed M, Cevik MO, Ogretmen B. Off-target function of the Sonic hedgehog inhibitor cyclopamine in mediating apoptosis via nitric oxide-dependent neutral sphingomyelinase 2/ceramide induction. Mol Cancer Ther. 2012 May; 11(5):1092-102. PMID: 22452947; PMCID: PMC3709261.
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    160. Beckham TH, Lu P, Cheng JC, Zhao D, Turner LS, Zhang X, Hoffman S, Armeson KE, Liu A, Marrison T, Hannun YA, Liu X, Beckham TH, Lu P, Cheng JC, Zhao D, Turner LS, Zhang X, Hoffman S, Armeson KE, Liu A, Marrison T, Hannun YA, Liu X. Acid ceramidase-mediated production of sphingosine 1-phosphate promotes prostate cancer invasion through upregulation of cathepsin B. Int J Cancer. 2012 Nov 01; 131(9):2034-43. PMID: 22322590; PMCID: PMC3384773.
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    161. Apraiz A, Idkowiak-Baldys J, Nieto-Rementería N, Boyano MD, Hannun YA, Asumendi A, Apraiz A, Idkowiak-Baldys J, Nieto-Rementer?a N, Boyano MD, Hannun YA, Asumendi A. Dihydroceramide accumulation and reactive oxygen species are distinct and nonessential events in 4-HPR-mediated leukemia cell death. Biochem Cell Biol. 2012 Apr; 90(2):209-23. PMID: 22428532; PMCID: PMC3663831.
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    162. Thevissen K, de Mello Tavares P, Xu D, Blankenship J, Vandenbosch D, Idkowiak-Baldys J, Govaert G, Bink A, Rozental S, de Groot PW, Davis TR, Kumamoto CA, Vargas G, Nimrichter L, Coenye T, Mitchell A, Roemer T, Hannun YA, Cammue BP, Thevissen K, de Mello Tavares P, Xu D, Blankenship J, Vandenbosch D, Idkowiak-Baldys J, Govaert G, Bink A, Rozental S, de Groot PW, Davis TR, Kumamoto CA, Vargas G, Nimrichter L, Coenye T, Mitchell A, Roemer T, Hannun YA, Cammue BP. The plant defensin RsAFP2 induces cell wall stress, septin mislocalization and accumulation of ceramides in Candida albicans. Mol Microbiol. 2012 Apr; 84(1):166-80. PMID: 22384976; PMCID: PMC3405362.
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    163. Canals D, Roddy P, Hannun YA, Canals D, Roddy P, Hannun YA. Protein phosphatase 1a mediates ceramide-induced ERM protein dephosphorylation: a novel mechanism independent of phosphatidylinositol 4, 5-biphosphate (PIP2) and myosin/ERM phosphatase. J Biol Chem. 2012 Mar 23; 287(13):10145-10155. PMID: 22311981; PMCID: PMC3323024.
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    164. Mullen TD, Hannun YA, Obeid LM, Mullen TD, Hannun YA, Obeid LM. Ceramide synthases at the centre of sphingolipid metabolism and biology. Biochem J. 2012 Feb 01; 441(3):789-802. PMID: 22248339; PMCID: PMC3689921.
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    165. Montefusco DJ, Newcomb B, Gandy JL, Brice SE, Matmati N, Cowart LA, Hannun YA, Montefusco DJ, Newcomb B, Gandy JL, Brice SE, Matmati N, Cowart LA, Hannun YA. Sphingoid bases and the serine catabolic enzyme CHA1 define a novel feedforward/feedback mechanism in the response to serine availability. J Biol Chem. 2012 Mar 16; 287(12):9280-9. PMID: 22277656; PMCID: PMC3308826.
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    166. Horres CR, Hannun YA, Horres CR, Hannun YA. The roles of neutral sphingomyelinases in neurological pathologies. Neurochem Res. 2012 Jun; 37(6):1137-49. PMID: 22237969.
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    167. Alvarez-Vasquez F, Riezman H, Hannun YA, Voit EO, Alvarez-Vasquez F, Riezman H, Hannun YA, Voit EO. Mathematical modeling and validation of the ergosterol pathway in Saccharomyces cerevisiae. PLoS One. 2011; 6(12):e28344. PMID: 22194828; PMCID: PMC3237449.
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    168. Apraiz A, Idkowiak-Baldys JK, Boyano MD, Pérez-Yarza G, Hannun YA, Asumendi A, Apraiz A, Idkowiak-Baldys JK, Boyano MD, P?rez-Yarza G, Hannun YA, Asumendi A. Evaluation of bioactive sphingolipids in 4-HPR-resistant leukemia cells. BMC Cancer. 2011 Nov 07; 11:477. PMID: 22061047; PMCID: PMC3218121.
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    169. Tripathi K, Matmati N, Zheng WJ, Hannun YA, Mohanty BK, Tripathi K, Matmati N, Zheng WJ, Hannun YA, Mohanty BK. Cellular morphogenesis under stress is influenced by the sphingolipid pathway gene ISC1 and DNA integrity checkpoint genes in Saccharomyces cerevisiae. Genetics. 2011 Oct; 189(2):533-47. PMID: 21840863; PMCID: PMC3189794.
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    170. Saddoughi SA, Garrett-Mayer E, Chaudhary U, O'Brien PE, Afrin LB, Day TA, Gillespie MB, Sharma AK, Wilhoit CS, Bostick R, Senkal CE, Hannun YA, Bielawski J, Simon GR, Shirai K, Ogretmen B, Saddoughi SA, Garrett-Mayer E, Chaudhary U, O'Brien PE, Afrin LB, Day TA, Gillespie MB, Sharma AK, Wilhoit CS, Bostick R, Senkal CE, Hannun YA, Bielawski J, Simon GR, Shirai K, Ogretmen B. Results of a phase II trial of gemcitabine plus doxorubicin in patients with recurrent head and neck cancers: serum C18-ceramide as a novel biomarker for monitoring response. Clin Cancer Res. 2011 Sep 15; 17(18):6097-105. PMID: 21791630; PMCID: PMC3176980.
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    171. Khavandgar Z, Poirier C, Clarke CJ, Li J, Wang N, McKee MD, Hannun YA, Murshed M, Khavandgar Z, Poirier C, Clarke CJ, Li J, Wang N, McKee MD, Hannun YA, Murshed M. A cell-autonomous requirement for neutral sphingomyelinase 2 in bone mineralization. J Cell Biol. 2011 Jul 25; 194(2):277-89. PMID: 21788370; PMCID: PMC3144407.
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    172. Heffernan-Stroud LA, Helke KL, Jenkins RW, De Costa AM, Hannun YA, Obeid LM, Heffernan-Stroud LA, Helke KL, Jenkins RW, De Costa AM, Hannun YA, Obeid LM. Defining a role for sphingosine kinase 1 in p53-dependent tumors. Oncogene. 2012 Mar 01; 31(9):1166-75. PMID: 21765468; PMCID: PMC3278571.
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    173. Barbosa AD, Osório H, Sims KJ, Almeida T, Alves M, Bielawski J, Amorim MA, Moradas-Ferreira P, Hannun YA, Costa V, Barbosa AD, Os?rio H, Sims KJ, Almeida T, Alves M, Bielawski J, Amorim MA, Moradas-Ferreira P, Hannun YA, Costa V. Role for Sit4p-dependent mitochondrial dysfunction in mediating the shortened chronological lifespan and oxidative stress sensitivity of Isc1p-deficient cells. Mol Microbiol. 2011 Jul; 81(2):515-27. PMID: 21707788; PMCID: PMC3133821.
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    174. Hannun YA, Obeid LM, Hannun YA, Obeid LM. Many ceramides. J Biol Chem. 2011 Aug 12; 286(32):27855-62. PMID: 21693702; PMCID: PMC3151029.
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    175. Hernández-Corbacho MJ, Jenkins RW, Clarke CJ, Hannun YA, Obeid LM, Snider AJ, Siskind LJ, Hern?ndez-Corbacho MJ, Jenkins RW, Clarke CJ, Hannun YA, Obeid LM, Snider AJ, Siskind LJ. Accumulation of long-chain glycosphingolipids during aging is prevented by caloric restriction. PLoS One. 2011; 6(6):e20411. PMID: 21687659; PMCID: PMC3110726.
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    176. Canals D, Perry DM, Jenkins RW, Hannun YA, Canals D, Perry DM, Jenkins RW, Hannun YA. Drug targeting of sphingolipid metabolism: sphingomyelinases and ceramidases. Br J Pharmacol. 2011 Jun; 163(4):694-712. PMID: 21615386; PMCID: PMC3111673.
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    177. Novgorodov SA, Wu BX, Gudz TI, Bielawski J, Ovchinnikova TV, Hannun YA, Obeid LM, Novgorodov SA, Wu BX, Gudz TI, Bielawski J, Ovchinnikova TV, Hannun YA, Obeid LM. Novel pathway of ceramide production in mitochondria: thioesterase and neutral ceramidase produce ceramide from sphingosine and acyl-CoA. J Biol Chem. 2011 Jul 15; 286(28):25352-62. PMID: 21613224; PMCID: PMC3137106.
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    178. Zhao L, Spassieva SD, Jucius TJ, Shultz LD, Shick HE, Macklin WB, Hannun YA, Obeid LM, Ackerman SL, Zhao L, Spassieva SD, Jucius TJ, Shultz LD, Shick HE, Macklin WB, Hannun YA, Obeid LM, Ackerman SL. A deficiency of ceramide biosynthesis causes cerebellar purkinje cell neurodegeneration and lipofuscin accumulation. PLoS Genet. 2011 May; 7(5):e1002063. PMID: 21625621; PMCID: PMC3098191.
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    179. Orr RK, Hoehn JL, Col NF, Wu BX, Clarke CJ, Matmati N, Montefusco D, Bartke N, Hannun YA. Identification of novel anionic phospholipid binding domains in neutral sphingomyelinase 2 with selective binding preference. J Biol Chem. 2011 Jun 24; 286(25):22362-71. PMID: 21550973; PMCID: PMC3121384.
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    180. Rahmaniyan M, Curley RW, Obeid LM, Hannun YA, Kraveka JM, Rahmaniyan M, Curley RW, Obeid LM, Hannun YA, Kraveka JM. Identification of dihydroceramide desaturase as a direct in vitro target for fenretinide. J Biol Chem. 2011 Jul 15; 286(28):24754-64. PMID: 21543327; PMCID: PMC3137051.
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    181. Clarke CJ, Mediwala K, Jenkins RW, Sutton CA, Tholanikunnel BG, Hannun YA, Clarke CJ, Mediwala K, Jenkins RW, Sutton CA, Tholanikunnel BG, Hannun YA. Neutral sphingomyelinase-2 mediates growth arrest by retinoic acid through modulation of ribosomal S6 kinase. J Biol Chem. 2011 Jun 17; 286(24):21565-76. PMID: 21536668; PMCID: PMC3122215.
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    182. Sun Y, Ran H, Liou B, Quinn B, Zamzow M, Zhang W, Bielawski J, Kitatani K, Setchell KD, Hannun YA, Grabowski GA, Sun Y, Ran H, Liou B, Quinn B, Zamzow M, Zhang W, Bielawski J, Kitatani K, Setchell KD, Hannun YA, Grabowski GA. Isofagomine in vivo effects in a neuronopathic Gaucher disease mouse. PLoS One. 2011 Apr 20; 6(4):e19037. PMID: 21533102; PMCID: PMC3080394.
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    183. Clarke CJ, Cloessner EA, Roddy PL, Hannun YA, Clarke CJ, Cloessner EA, Roddy PL, Hannun YA. Neutral sphingomyelinase 2 (nSMase2) is the primary neutral sphingomyelinase isoform activated by tumour necrosis factor-a in MCF-7 cells. Biochem J. 2011 Apr 15; 435(2):381-90. PMID: 21303347; PMCID: PMC3715995.
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    184. El-Osta MA, Idkowiak-Baldys J, Hannun YA, El-Osta MA, Idkowiak-Baldys J, Hannun YA. Delayed phosphorylation of classical protein kinase C (PKC) substrates requires PKC internalization and formation of the pericentrion in a phospholipase D (PLD)-dependent manner. J Biol Chem. 2011 Jun 03; 286(22):19340-53. PMID: 21478146; PMCID: PMC3103312.
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    185. Mullen TD, Jenkins RW, Clarke CJ, Bielawski J, Hannun YA, Obeid LM, Mullen TD, Jenkins RW, Clarke CJ, Bielawski J, Hannun YA, Obeid LM. Ceramide synthase-dependent ceramide generation and programmed cell death: involvement of salvage pathway in regulating postmitochondrial events. J Biol Chem. 2011 May 06; 286(18):15929-42. PMID: 21388949; PMCID: PMC3091202.
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    186. Jenkins RW, Clarke CJ, Canals D, Snider AJ, Gault CR, Heffernan-Stroud L, Wu BX, Simbari F, Roddy P, Kitatani K, Obeid LM, Hannun YA, Jenkins RW, Clarke CJ, Canals D, Snider AJ, Gault CR, Heffernan-Stroud L, Wu BX, Simbari F, Roddy P, Kitatani K, Obeid LM, Hannun YA. Regulation of CC ligand 5/RANTES by acid sphingomyelinase and acid ceramidase. J Biol Chem. 2011 Apr 15; 286(15):13292-303. PMID: 21335555; PMCID: PMC3075676.
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    187. Thayyullathil F, Chathoth S, Hago A, Patel M, Szulc ZM, Hannun Y, Galadari S, Thayyullathil F, Chathoth S, Hago A, Patel M, Szulc ZM, Hannun Y, Galadari S. Purification and characterization of a second type of neutral ceramidase from rat brain: a second more hydrophobic form of rat brain ceramidase. Biochim Biophys Acta. 2011 Apr; 1811(4):242-52. PMID: 21224012.
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    188. Shirai K, Kaneshiro T, Wada M, Furuya H, Bielawski J, Hannun YA, Obeid LM, Ogretmen B, Kawamori T, Shirai K, Kaneshiro T, Wada M, Furuya H, Bielawski J, Hannun YA, Obeid LM, Ogretmen B, Kawamori T. A role of sphingosine kinase 1 in head and neck carcinogenesis. Cancer Prev Res (Phila). 2011 Mar; 4(3):454-62. PMID: 21209394; PMCID: PMC3342666.
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    189. Jenkins RW, Idkowiak-Baldys J, Simbari F, Canals D, Roddy P, Riner CD, Clarke CJ, Hannun YA, Jenkins RW, Idkowiak-Baldys J, Simbari F, Canals D, Roddy P, Riner CD, Clarke CJ, Hannun YA. A novel mechanism of lysosomal acid sphingomyelinase maturation: requirement for carboxyl-terminal proteolytic processing. J Biol Chem. 2011 Feb 04; 286(5):3777-88. PMID: 21098024; PMCID: PMC3030379.
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    190. Hou Q, Jin J, Zhou H, Novgorodov SA, Bielawska A, Szulc ZM, Hannun YA, Obeid LM, Hsu YT, Hou Q, Jin J, Zhou H, Novgorodov SA, Bielawska A, Szulc ZM, Hannun YA, Obeid LM, Hsu YT. Mitochondrially targeted ceramides preferentially promote autophagy, retard cell growth, and induce apoptosis. J Lipid Res. 2011 Feb; 52(2):278-88. PMID: 21081756; PMCID: PMC3023548.
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    191. Clarke CJ, Wu BX, Hannun YA, Clarke CJ, Wu BX, Hannun YA. The neutral sphingomyelinase family: identifying biochemical connections. Adv Enzyme Regul. 2011; 51(1):51-8. PMID: 21035485; PMCID: PMC3078995.
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    192. Mullen TD, Spassieva S, Jenkins RW, Kitatani K, Bielawski J, Hannun YA, Obeid LM, Mullen TD, Spassieva S, Jenkins RW, Kitatani K, Bielawski J, Hannun YA, Obeid LM. Selective knockdown of ceramide synthases reveals complex interregulation of sphingolipid metabolism. J Lipid Res. 2011 Jan; 52(1):68-77. PMID: 20940143; PMCID: PMC2999923.
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    193. Cowart LA, Gandy JL, Tholanikunnel B, Hannun YA, Cowart LA, Gandy JL, Tholanikunnel B, Hannun YA. Sphingolipids mediate formation of mRNA processing bodies during the heat-stress response of Saccharomyces cerevisiae. Biochem J. 2010 Oct 01; 431(1):31-8. PMID: 20629639; PMCID: PMC3804835.
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    194. Szulc ZM, Bai A, Bielawski J, Mayroo N, Miller DE, Gracz H, Hannun YA, Bielawska A, Szulc ZM, Bai A, Bielawski J, Mayroo N, Miller DE, Gracz H, Hannun YA, Bielawska A. Synthesis, NMR characterization and divergent biological actions of 2'-hydroxy-ceramide/dihydroceramide stereoisomers in MCF7 cells. Bioorg Med Chem. 2010 Nov 01; 18(21):7565-79. PMID: 20851613; PMCID: PMC2956829.
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    195. An D, Na C, Bielawski J, Hannun YA, Kasper DL, An D, Na C, Bielawski J, Hannun YA, Kasper DL. Membrane sphingolipids as essential molecular signals for Bacteroides survival in the intestine. Proc Natl Acad Sci U S A. 2011 Mar 15; 108 Suppl 1:4666-71. PMID: 20855611; PMCID: PMC3063596.
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    196. Jenkins RW, Canals D, Idkowiak-Baldys J, Simbari F, Roddy P, Perry DM, Kitatani K, Luberto C, Hannun YA, Jenkins RW, Canals D, Idkowiak-Baldys J, Simbari F, Roddy P, Perry DM, Kitatani K, Luberto C, Hannun YA. Regulated secretion of acid sphingomyelinase: implications for selectivity of ceramide formation. J Biol Chem. 2010 Nov 12; 285(46):35706-18. PMID: 20807762; PMCID: PMC2975195.
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    197. Milhas D, Clarke CJ, Idkowiak-Baldys J, Canals D, Hannun YA, Milhas D, Clarke CJ, Idkowiak-Baldys J, Canals D, Hannun YA. Anterograde and retrograde transport of neutral sphingomyelinase-2 between the Golgi and the plasma membrane. Biochim Biophys Acta. 2010 Dec; 1801(12):1361-74. PMID: 20713176; PMCID: PMC2957534.
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    198. Canals D, Jenkins RW, Roddy P, Hernández-Corbacho MJ, Obeid LM, Hannun YA, Canals D, Jenkins RW, Roddy P, Hern?ndez-Corbacho MJ, Obeid LM, Hannun YA. Differential effects of ceramide and sphingosine 1-phosphate on ERM phosphorylation: probing sphingolipid signaling at the outer plasma membrane. J Biol Chem. 2010 Oct 15; 285(42):32476-85. PMID: 20679347; PMCID: PMC2952249.
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    199. Hammad SM, Pierce JS, Soodavar F, Smith KJ, Al Gadban MM, Rembiesa B, Klein RL, Hannun YA, Bielawski J, Bielawska A, Hammad SM, Pierce JS, Soodavar F, Smith KJ, Al Gadban MM, Rembiesa B, Klein RL, Hannun YA, Bielawski J, Bielawska A. Blood sphingolipidomics in healthy humans: impact of sample collection methodology. J Lipid Res. 2010 Oct; 51(10):3074-87. PMID: 20660127; PMCID: PMC2936747.
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    200. Zeidan YH, Hannun YA, Zeidan YH, Hannun YA. The acid sphingomyelinase/ceramide pathway: biomedical significance and mechanisms of regulation. Curr Mol Med. 2010 Jul; 10(5):454-66. PMID: 20540705.
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    201. Wu BX, Clarke CJ, Hannun YA, Wu BX, Clarke CJ, Hannun YA. Mammalian neutral sphingomyelinases: regulation and roles in cell signaling responses. Neuromolecular Med. 2010 Dec; 12(4):320-30. PMID: 20552297; PMCID: PMC3405913.
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    202. Uchida Y, Houben E, Park K, Douangpanya S, Lee YM, Wu BX, Hannun YA, Radin NS, Elias PM, Holleran WM, Uchida Y, Houben E, Park K, Douangpanya S, Lee YM, Wu BX, Hannun YA, Radin NS, Elias PM, Holleran WM. Hydrolytic pathway protects against ceramide-induced apoptosis in keratinocytes exposed to UVB. J Invest Dermatol. 2010 Oct; 130(10):2472-80. PMID: 20520628.
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    203. Wu BX, Rajagopalan V, Roddy PL, Clarke CJ, Hannun YA, Wu BX, Rajagopalan V, Roddy PL, Clarke CJ, Hannun YA. Identification and characterization of murine mitochondria-associated neutral sphingomyelinase (MA-nSMase), the mammalian sphingomyelin phosphodiesterase 5. J Biol Chem. 2010 Jun 04; 285(23):17993-8002. PMID: 20378533; PMCID: PMC2878561.
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    204. Idkowiak-Baldys J, Apraiz A, Li L, Rahmaniyan M, Clarke CJ, Kraveka JM, Asumendi A, Hannun YA, Idkowiak-Baldys J, Apraiz A, Li L, Rahmaniyan M, Clarke CJ, Kraveka JM, Asumendi A, Hannun YA. Dihydroceramide desaturase activity is modulated by oxidative stress. Biochem J. 2010 Mar 29; 427(2):265-74. PMID: 20105137; PMCID: PMC3086801.
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    205. Devillard R, Galvani S, Thiers JC, Guenet JL, Hannun Y, Bielawski J, Nègre-Salvayre A, Salvayre R, Augé N, Devillard R, Galvani S, Thiers JC, Guenet JL, Hannun Y, Bielawski J, N?gre-Salvayre A, Salvayre R, Aug? N. Stress-induced sphingolipid signaling: role of type-2 neutral sphingomyelinase in murine cell apoptosis and proliferation. PLoS One. 2010 Mar 23; 5(3):e9826. PMID: 20352118; PMCID: PMC2843740.
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    206. Cowart LA, Shotwell M, Worley ML, Richards AJ, Montefusco DJ, Hannun YA, Lu X, Cowart LA, Shotwell M, Worley ML, Richards AJ, Montefusco DJ, Hannun YA, Lu X. Revealing a signaling role of phytosphingosine-1-phosphate in yeast. Mol Syst Biol. 2010; 6:349. PMID: 20160710; PMCID: PMC2835565.
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    207. Matmati K, Matmati N, Hannun YA, Rumboldt Z, Patel S, Lazarchick J, Stuart R, Giglio P, Matmati K, Matmati N, Hannun YA, Rumboldt Z, Patel S, Lazarchick J, Stuart R, Giglio P. Dural MALT lymphoma with disseminated disease. Hematol Rep. 2010 Jan 26; 2(1):e10. PMID: 22184513; PMCID: PMC3222263.
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    208. Sun Y, Liou B, Ran H, Skelton MR, Williams MT, Vorhees CV, Kitatani K, Hannun YA, Witte DP, Xu YH, Grabowski GA, Sun Y, Liou B, Ran H, Skelton MR, Williams MT, Vorhees CV, Kitatani K, Hannun YA, Witte DP, Xu YH, Grabowski GA. Neuronopathic Gaucher disease in the mouse: viable combined selective saposin C deficiency and mutant glucocerebrosidase (V394L) mice with glucosylsphingosine and glucosylceramide accumulation and progressive neurological deficits. Hum Mol Genet. 2010 Mar 15; 19(6):1088-97. PMID: 20047948; PMCID: PMC2830832.
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    209. Gault CR, Obeid LM, Hannun YA, Gault CR, Obeid LM, Hannun YA. An overview of sphingolipid metabolism: from synthesis to breakdown. Adv Exp Med Biol. 2010; 688:1-23. PMID: 20919643; PMCID: PMC3069696.
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    210. Voit EO, Alvarez-Vasquez F, Hannun YA, Voit EO, Alvarez-Vasquez F, Hannun YA. Computational analysis of sphingolipid pathway systems. Adv Exp Med Biol. 2010; 688:264-75. PMID: 20919661.
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    211. Philipp S, Puchert M, Adam-Klages S, Tchikov V, Winoto-Morbach S, Mathieu S, Deerberg A, Kolker L, Marchesini N, Kabelitz D, Hannun YA, Schütze S, Adam D, Philipp S, Puchert M, Adam-Klages S, Tchikov V, Winoto-Morbach S, Mathieu S, Deerberg A, Kolker L, Marchesini N, Kabelitz D, Hannun YA, Sch?tze S, Adam D. The Polycomb group protein EED couples TNF receptor 1 to neutral sphingomyelinase. Proc Natl Acad Sci U S A. 2010 Jan 19; 107(3):1112-7. PMID: 20080539; PMCID: PMC2824292.
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    212. Sun Y, Ran H, Zamzow M, Kitatani K, Skelton MR, Williams MT, Vorhees CV, Witte DP, Hannun YA, Grabowski GA, Sun Y, Ran H, Zamzow M, Kitatani K, Skelton MR, Williams MT, Vorhees CV, Witte DP, Hannun YA, Grabowski GA. Specific saposin C deficiency: CNS impairment and acid beta-glucosidase effects in the mouse. Hum Mol Genet. 2010 Feb 15; 19(4):634-47. PMID: 20015957; PMCID: PMC2807372.
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    213. Pata MO, Hannun YA, Ng CK, Pata MO, Hannun YA, Ng CK. Plant sphingolipids: decoding the enigma of the Sphinx. New Phytol. 2010 Feb; 185(3):611-30. PMID: 20028469; PMCID: PMC2848707.
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    214. Liu X, Cheng JC, Turner LS, Elojeimy S, Beckham TH, Bielawska A, Keane TE, Hannun YA, Norris JS, Liu X, Cheng JC, Turner LS, Elojeimy S, Beckham TH, Bielawska A, Keane TE, Hannun YA, Norris JS. Acid ceramidase upregulation in prostate cancer: role in tumor development and implications for therapy. Expert Opin Ther Targets. 2009 Dec; 13(12):1449-58. PMID: 19874262; PMCID: PMC2796572.
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    215. Thevissen K, Yen WL, Carmona-Gutierrez D, Idkowiak-Baldys J, Aerts AM, François IE, Madeo F, Klionsky DJ, Hannun YA, Cammue BP, Thevissen K, Yen WL, Carmona-Gutierrez D, Idkowiak-Baldys J, Aerts AM, Fran?ois IE, Madeo F, Klionsky DJ, Hannun YA, Cammue BP. Skn1 and Ipt1 negatively regulate autophagy in Saccharomyces cerevisiae. FEMS Microbiol Lett. 2010 Feb; 303(2):163-8. PMID: 20030721; PMCID: PMC2818745.
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    216. Milhas D, Clarke CJ, Hannun YA, Milhas D, Clarke CJ, Hannun YA. Sphingomyelin metabolism at the plasma membrane: implications for bioactive sphingolipids. FEBS Lett. 2010 May 03; 584(9):1887-94. PMID: 19857494; PMCID: PMC2856805.
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    217. Senkal CE, Ponnusamy S, Bielawski J, Hannun YA, Ogretmen B, Senkal CE, Ponnusamy S, Bielawski J, Hannun YA, Ogretmen B. Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways. FASEB J. 2010 Jan; 24(1):296-308. PMID: 19723703; PMCID: PMC2797032.
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    218. Gustafsson K, Sander B, Bielawski J, Hannun YA, Flygare J, Gustafsson K, Sander B, Bielawski J, Hannun YA, Flygare J. Potentiation of cannabinoid-induced cytotoxicity in mantle cell lymphoma through modulation of ceramide metabolism. Mol Cancer Res. 2009 Jul; 7(7):1086-98. PMID: 19609004; PMCID: PMC3077284.
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    219. Jin J, Mullen TD, Hou Q, Bielawski J, Bielawska A, Zhang X, Obeid LM, Hannun YA, Hsu YT, Jin J, Mullen TD, Hou Q, Bielawski J, Bielawska A, Zhang X, Obeid LM, Hannun YA, Hsu YT. AMPK inhibitor Compound C stimulates ceramide production and promotes Bax redistribution and apoptosis in MCF7 breast carcinoma cells. J Lipid Res. 2009 Dec; 50(12):2389-97. PMID: 19528633; PMCID: PMC2781311.
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    220. Idkowiak-Baldys J, Baldys A, Raymond JR, Hannun YA, Idkowiak-Baldys J, Baldys A, Raymond JR, Hannun YA. Sustained receptor stimulation leads to sequestration of recycling endosomes in a classical protein kinase C- and phospholipase D-dependent manner. J Biol Chem. 2009 Aug 14; 284(33):22322-22331. PMID: 19525236; PMCID: PMC2755955.
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    221. Jenkins RW, Canals D, Hannun YA, Jenkins RW, Canals D, Hannun YA. Roles and regulation of secretory and lysosomal acid sphingomyelinase. Cell Signal. 2009 Jun; 21(6):836-46. PMID: 19385042; PMCID: PMC3488588.
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    222. Yang G, Badeanlou L, Bielawski J, Roberts AJ, Hannun YA, Samad F, Yang G, Badeanlou L, Bielawski J, Roberts AJ, Hannun YA, Samad F. Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome. Am J Physiol Endocrinol Metab. 2009 Jul; 297(1):E211-24. PMID: 19435851; PMCID: PMC2711669.
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    223. Wu BX, Zeidan YH, Hannun YA, Wu BX, Zeidan YH, Hannun YA. Downregulation of neutral ceramidase by gemcitabine: Implications for cell cycle regulation. Biochim Biophys Acta. 2009 Aug; 1791(8):730-9. PMID: 19345744; PMCID: PMC2788435.
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    224. Hannun YA, Hannun YA. We need to tackle the mismatch between supply and demand. Nature. 2009 Mar 26; 458(7237):404. PMID: 19325607.
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    225. Kitatani K, Sheldon K, Anelli V, Jenkins RW, Sun Y, Grabowski GA, Obeid LM, Hannun YA, Kitatani K, Sheldon K, Anelli V, Jenkins RW, Sun Y, Grabowski GA, Obeid LM, Hannun YA. Acid beta-glucosidase 1 counteracts p38delta-dependent induction of interleukin-6: possible role for ceramide as an anti-inflammatory lipid. J Biol Chem. 2009 May 08; 284(19):12979-88. PMID: 19279008; PMCID: PMC2676030.
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    288. Liu X, Zeidan YH, Elojeimy S, Holman DH, El-Zawahry AM, Guo GW, Bielawska A, Bielawski J, Szulc Z, Rubinchik S, Dong JY, Keane TE, Tavassoli M, Hannun YA, Norris JS, Liu X, Zeidan YH, Elojeimy S, Holman DH, El-Zawahry AM, Guo GW, Bielawska A, Bielawski J, Szulc Z, Rubinchik S, Dong JY, Keane TE, Tavassoli M, Hannun YA, Norris JS. Involvement of sphingolipids in apoptin-induced cell killing. Mol Ther. 2006 Nov; 14(5):627-36. PMID: 16926120.
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    289. Szulc ZM, Bielawski J, Gracz H, Gustilo M, Mayroo N, Hannun YA, Obeid LM, Bielawska A, Szulc ZM, Bielawski J, Gracz H, Gustilo M, Mayroo N, Hannun YA, Obeid LM, Bielawska A. Tailoring structure-function and targeting properties of ceramides by site-specific cationization. Bioorg Med Chem. 2006 Nov 01; 14(21):7083-104. PMID: 16919460.
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    290. Orr RK, Hoehn JL, Col NF, Elojeimy S, Holman DH, Liu X, El-Zawahry A, Villani M, Cheng JC, Mahdy A, Zeidan Y, Bielwaska A, Hannun YA, Norris JS. New insights on the use of desipramine as an inhibitor for acid ceramidase. FEBS Lett. 2006 Aug 21; 580(19):4751-6. PMID: 16901483.
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    291. Liu X, Elojeimy S, El-Zawahry AM, Holman DH, Bielawska A, Bielawski J, Rubinchik S, Guo GW, Dong JY, Keane T, Hannun YA, Tavassoli M, Norris JS, Liu X, Elojeimy S, El-Zawahry AM, Holman DH, Bielawska A, Bielawski J, Rubinchik S, Guo GW, Dong JY, Keane T, Hannun YA, Tavassoli M, Norris JS. Modulation of ceramide metabolism enhances viral protein apoptin's cytotoxicity in prostate cancer. Mol Ther. 2006 Nov; 14(5):637-46. PMID: 16887394.
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    292. Clarke CJ, Hannun YA, Clarke CJ, Hannun YA. Neutral sphingomyelinases and nSMase2: bridging the gaps. Biochim Biophys Acta. 2006 Dec; 1758(12):1893-901. PMID: 16938269.
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    293. Snook CF, Jones JA, Hannun YA, Snook CF, Jones JA, Hannun YA. Sphingolipid-binding proteins. Biochim Biophys Acta. 2006 Aug; 1761(8):927-46. PMID: 16901751.
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    294. Zeidan YH, Pettus BJ, Elojeimy S, Taha T, Obeid LM, Kawamori T, Norris JS, Hannun YA, Zeidan YH, Pettus BJ, Elojeimy S, Taha T, Obeid LM, Kawamori T, Norris JS, Hannun YA. Acid ceramidase but not acid sphingomyelinase is required for tumor necrosis factor-{alpha}-induced PGE2 production. J Biol Chem. 2006 Aug 25; 281(34):24695-703. PMID: 16803890.
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    295. Norris JS, Bielawska A, Day T, El-Zawahri A, ElOjeimy S, Hannun Y, Holman D, Hyer M, Landon C, Lowe S, Dong JY, McKillop J, Norris K, Obeid L, Rubinchik S, Tavassoli M, Tomlinson S, Voelkel-Johnson C, Liu X, Norris JS, Bielawska A, Day T, El-Zawahri A, ElOjeimy S, Hannun Y, Holman D, Hyer M, Landon C, Lowe S, Dong JY, McKillop J, Norris K, Obeid L, Rubinchik S, Tavassoli M, Tomlinson S, Voelkel-Johnson C, Liu X. Combined therapeutic use of AdGFPFasL and small molecule inhibitors of ceramide metabolism in prostate and head and neck cancers: a status report. Cancer Gene Ther. 2006 Dec; 13(12):1045-51. PMID: 16763610.
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    296. El Alwani M, Wu BX, Obeid LM, Hannun YA, El Alwani M, Wu BX, Obeid LM, Hannun YA. Bioactive sphingolipids in the modulation of the inflammatory response. Pharmacol Ther. 2006 Oct; 112(1):171-83. PMID: 16759708.
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    297. Idkowiak-Baldys J, Becker KP, Kitatani K, Hannun YA, Idkowiak-Baldys J, Becker KP, Kitatani K, Hannun YA. Dynamic sequestration of the recycling compartment by classical protein kinase C. J Biol Chem. 2006 Aug 04; 281(31):22321-22331. PMID: 16751194.
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    298. Dindo D, Dahm F, Szulc Z, Bielawska A, Obeid LM, Hannun YA, Graf R, Clavien PA, Dindo D, Dahm F, Szulc Z, Bielawska A, Obeid LM, Hannun YA, Graf R, Clavien PA. Cationic long-chain ceramide LCL-30 induces cell death by mitochondrial targeting in SW403 cells. Mol Cancer Ther. 2006 Jun; 5(6):1520-9. PMID: 16818511.
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    299. Bielawski J, Szulc ZM, Hannun YA, Bielawska A, Bielawski J, Szulc ZM, Hannun YA, Bielawska A. Simultaneous quantitative analysis of bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry. Methods. 2006 Jun; 39(2):82-91. PMID: 16828308.
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    300. Taha TA, Hannun YA, Obeid LM, Taha TA, Hannun YA, Obeid LM. Sphingosine kinase: biochemical and cellular regulation and role in disease. J Biochem Mol Biol. 2006 Mar 31; 39(2):113-31. PMID: 16584625.
      Citations:    
    301. Senkal CE, Ponnusamy S, Rossi MJ, Sundararaj K, Szulc Z, Bielawski J, Bielawska A, Meyer M, Cobanoglu B, Koybasi S, Sinha D, Day TA, Obeid LM, Hannun YA, Ogretmen B, Senkal CE, Ponnusamy S, Rossi MJ, Sundararaj K, Szulc Z, Bielawski J, Bielawska A, Meyer M, Cobanoglu B, Koybasi S, Sinha D, Day TA, Obeid LM, Hannun YA, Ogretmen B. Potent antitumor activity of a novel cationic pyridinium-ceramide alone or in combination with gemcitabine against human head and neck squamous cell carcinomas in vitro and in vivo. J Pharmacol Exp Ther. 2006 Jun; 317(3):1188-99. PMID: 16510697.
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    302. Cowart LA, Okamoto Y, Lu X, Hannun YA, Cowart LA, Okamoto Y, Lu X, Hannun YA. Distinct roles for de novo versus hydrolytic pathways of sphingolipid biosynthesis in Saccharomyces cerevisiae. Biochem J. 2006 Feb 01; 393(Pt 3):733-40. PMID: 16201964; PMCID: PMC1360726.
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    303. Galadari S, Wu BX, Mao C, Roddy P, El Bawab S, Hannun YA, Galadari S, Wu BX, Mao C, Roddy P, El Bawab S, Hannun YA. Identification of a novel amidase motif in neutral ceramidase. Biochem J. 2006 Feb 01; 393(Pt 3):687-95. PMID: 16229686; PMCID: PMC1360721.
      Citations:    
    304. Sultan I, Senkal CE, Ponnusamy S, Bielawski J, Szulc Z, Bielawska A, Hannun YA, Ogretmen B, Sultan I, Senkal CE, Ponnusamy S, Bielawski J, Szulc Z, Bielawska A, Hannun YA, Ogretmen B. Regulation of the sphingosine-recycling pathway for ceramide generation by oxidative stress, and its role in controlling c-Myc/Max function. Biochem J. 2006 Jan 15; 393(Pt 2):513-21. PMID: 16201965; PMCID: PMC1360701.
      Citations:    
    305. Taha TA, Kitatani K, El-Alwani M, Bielawski J, Hannun YA, Obeid LM, Taha TA, Kitatani K, El-Alwani M, Bielawski J, Hannun YA, Obeid LM. Loss of sphingosine kinase-1 activates the intrinsic pathway of programmed cell death: modulation of sphingolipid levels and the induction of apoptosis. FASEB J. 2006 Mar; 20(3):482-4. PMID: 16507765.
      Citations:    
    306. Kono M, Dreier JL, Ellis JM, Allende ML, Kalkofen DN, Sanders KM, Bielawski J, Bielawska A, Hannun YA, Proia RL, Kono M, Dreier JL, Ellis JM, Allende ML, Kalkofen DN, Sanders KM, Bielawski J, Bielawska A, Hannun YA, Proia RL. Neutral ceramidase encoded by the Asah2 gene is essential for the intestinal degradation of sphingolipids. J Biol Chem. 2006 Mar 17; 281(11):7324-31. PMID: 16380386.
      Citations:    
    307. Osawa Y, Hannun YA, Proia RL, Brenner DA, Osawa Y, Hannun YA, Proia RL, Brenner DA. Roles of AKT and sphingosine kinase in the antiapoptotic effects of bile duct ligation in mouse liver. Hepatology. 2005 Dec; 42(6):1320-8. PMID: 16317686.
      Citations:    
    308. Kawamori T, Osta W, Johnson KR, Pettus BJ, Bielawski J, Tanaka T, Wargovich MJ, Reddy BS, Hannun YA, Obeid LM, Zhou D, Kawamori T, Osta W, Johnson KR, Pettus BJ, Bielawski J, Tanaka T, Wargovich MJ, Reddy BS, Hannun YA, Obeid LM, Zhou D. Sphingosine kinase 1 is up-regulated in colon carcinogenesis. FASEB J. 2006 Feb; 20(2):386-8. PMID: 16319132.
      Citations:    
    309. Bu S, Yamanaka M, Pei H, Bielawska A, Bielawski J, Hannun YA, Obeid L, Trojanowska M, Bu S, Yamanaka M, Pei H, Bielawska A, Bielawski J, Hannun YA, Obeid L, Trojanowska M. Dihydrosphingosine 1-phosphate stimulates MMP1 gene expression via activation of ERK1/2-Ets1 pathway in human fibroblasts. FASEB J. 2006 Jan; 20(1):184-6. PMID: 16278291.
      Citations:    
    310. Cowart LA, Hannun YA, Cowart LA, Hannun YA. Using genomic and lipidomic strategies to investigate sphingolipid function in the yeast heat-stress response. Biochem Soc Trans. 2005 Nov; 33(Pt 5):1166-9. PMID: 16246073.
      Citations:    
    311. Jones JA, Rawles R, Hannun YA, Jones JA, Rawles R, Hannun YA. Identification of a novel phosphatidic acid binding domain in protein phosphatase-1. Biochemistry. 2005 Oct 11; 44(40):13235-45. PMID: 16201749.
      Citations:    
    312. Voelkel-Johnson C, Hannun YA, El-Zawahry A, Voelkel-Johnson C, Hannun YA, El-Zawahry A. Resistance to TRAIL is associated with defects in ceramide signaling that can be overcome by exogenous C6-ceramide without requiring down-regulation of cellular FLICE inhibitory protein. Mol Cancer Ther. 2005 Sep; 4(9):1320-7. PMID: 16170023.
      Citations:    
    313. Becker KP, Hannun YA, Becker KP, Hannun YA. Protein kinase C and phospholipase D: intimate interactions in intracellular signaling. Cell Mol Life Sci. 2005 Jul; 62(13):1448-61. PMID: 15924269.
      Citations:    
    314. Osawa Y, Uchinami H, Bielawski J, Schwabe RF, Hannun YA, Brenner DA, Osawa Y, Uchinami H, Bielawski J, Schwabe RF, Hannun YA, Brenner DA. Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha. J Biol Chem. 2005 Jul 29; 280(30):27879-87. PMID: 15946935.
      Citations:    
    315. Pettus BJ, Kitatani K, Chalfant CE, Taha TA, Kawamori T, Bielawski J, Obeid LM, Hannun YA, Pettus BJ, Kitatani K, Chalfant CE, Taha TA, Kawamori T, Bielawski J, Obeid LM, Hannun YA. The coordination of prostaglandin E2 production by sphingosine-1-phosphate and ceramide-1-phosphate. Mol Pharmacol. 2005 Aug; 68(2):330-5. PMID: 15900018.
      Citations:    
    316. Birbes H, Luberto C, Hsu YT, El Bawab S, Hannun YA, Obeid LM, Birbes H, Luberto C, Hsu YT, El Bawab S, Hannun YA, Obeid LM. A mitochondrial pool of sphingomyelin is involved in TNFalpha-induced Bax translocation to mitochondria. Biochem J. 2005 Mar 15; 386(Pt 3):445-51. PMID: 15516208; PMCID: PMC1134862.
      Citations:    
    317. Novgorodov SA, Szulc ZM, Luberto C, Jones JA, Bielawski J, Bielawska A, Hannun YA, Obeid LM, Novgorodov SA, Szulc ZM, Luberto C, Jones JA, Bielawski J, Bielawska A, Hannun YA, Obeid LM. Positively charged ceramide is a potent inducer of mitochondrial permeabilization. J Biol Chem. 2005 Apr 22; 280(16):16096-105. PMID: 15722351.
      Citations:    
    318. Taha TA, Kitatani K, Bielawski J, Cho W, Hannun YA, Obeid LM, Taha TA, Kitatani K, Bielawski J, Cho W, Hannun YA, Obeid LM. Tumor necrosis factor induces the loss of sphingosine kinase-1 by a cathepsin B-dependent mechanism. J Biol Chem. 2005 Apr 29; 280(17):17196-202. PMID: 15710602.
      Citations:    
    319. Alvarez-Vasquez F, Sims KJ, Cowart LA, Okamoto Y, Voit EO, Hannun YA, Alvarez-Vasquez F, Sims KJ, Cowart LA, Okamoto Y, Voit EO, Hannun YA. Simulation and validation of modelled sphingolipid metabolism in Saccharomyces cerevisiae. Nature. 2005 Jan 27; 433(7024):425-30. PMID: 15674294.
      Citations:    
    320. Hu W, Xu R, Zhang G, Jin J, Szulc ZM, Bielawski J, Hannun YA, Obeid LM, Mao C, Hu W, Xu R, Zhang G, Jin J, Szulc ZM, Bielawski J, Hannun YA, Obeid LM, Mao C. Golgi fragmentation is associated with ceramide-induced cellular effects. Mol Biol Cell. 2005 Mar; 16(3):1555-67. PMID: 15647381; PMCID: PMC551515.
      Citations:    
    321. Rossi MJ, Sundararaj K, Koybasi S, Phillips MS, Szulc ZM, Bielawska A, Day TA, Obeid LM, Hannun YA, Ogretmen B, Rossi MJ, Sundararaj K, Koybasi S, Phillips MS, Szulc ZM, Bielawska A, Day TA, Obeid LM, Hannun YA, Ogretmen B. Inhibition of growth and telomerase activity by novel cationic ceramide analogs with high solubility in human head and neck squamous cell carcinoma cells. Otolaryngol Head Neck Surg. 2005 Jan; 132(1):55-62. PMID: 15632910.
      Citations:    
    322. Vaena de Avalos S, Su X, Zhang M, Okamoto Y, Dowhan W, Hannun YA, Vaena de Avalos S, Su X, Zhang M, Okamoto Y, Dowhan W, Hannun YA. The phosphatidylglycerol/cardiolipin biosynthetic pathway is required for the activation of inositol phosphosphingolipid phospholipase C, Isc1p, during growth of Saccharomyces cerevisiae. J Biol Chem. 2005 Feb 25; 280(8):7170-7. PMID: 15611094.
      Citations:    
    323. Becker KP, Kitatani K, Idkowiak-Baldys J, Bielawski J, Hannun YA, Becker KP, Kitatani K, Idkowiak-Baldys J, Bielawski J, Hannun YA. Selective inhibition of juxtanuclear translocation of protein kinase C betaII by a negative feedback mechanism involving ceramide formed from the salvage pathway. J Biol Chem. 2005 Jan 28; 280(4):2606-12. PMID: 15546881.
      Citations:    
    324. Pinto FR, Cowart LA, Hannun YA, Rohrer B, Almeida JS, Pinto FR, Cowart LA, Hannun YA, Rohrer B, Almeida JS. Local correlation of expression profiles with gene annotations--proof of concept for a general conciliatory method. Bioinformatics. 2005 Apr 01; 21(7):1037-45. PMID: 15509607.
      Citations:    
    325. Yamanaka M, Shegogue D, Pei H, Bu S, Bielawska A, Bielawski J, Pettus B, Hannun YA, Obeid L, Trojanowska M, Yamanaka M, Shegogue D, Pei H, Bu S, Bielawska A, Bielawski J, Pettus B, Hannun YA, Obeid L, Trojanowska M. Sphingosine kinase 1 (SPHK1) is induced by transforming growth factor-beta and mediates TIMP-1 up-regulation. J Biol Chem. 2004 Dec 24; 279(52):53994-4001. PMID: 15485866.
      Citations:    
    326. Koybasi S, Senkal CE, Sundararaj K, Spassieva S, Bielawski J, Osta W, Day TA, Jiang JC, Jazwinski SM, Hannun YA, Obeid LM, Ogretmen B, Koybasi S, Senkal CE, Sundararaj K, Spassieva S, Bielawski J, Osta W, Day TA, Jiang JC, Jazwinski SM, Hannun YA, Obeid LM, Ogretmen B. Defects in cell growth regulation by C18:0-ceramide and longevity assurance gene 1 in human head and neck squamous cell carcinomas. J Biol Chem. 2004 Oct 22; 279(43):44311-9. PMID: 15317812.
      Citations:    
    327. Osta WA, Chen Y, Mikhitarian K, Mitas M, Salem M, Hannun YA, Cole DJ, Gillanders WE, Osta WA, Chen Y, Mikhitarian K, Mitas M, Salem M, Hannun YA, Cole DJ, Gillanders WE. EpCAM is overexpressed in breast cancer and is a potential target for breast cancer gene therapy. Cancer Res. 2004 Aug 15; 64(16):5818-24. PMID: 15313925.
      Citations:    
    328. Ogretmen B, Hannun YA, Ogretmen B, Hannun YA. Biologically active sphingolipids in cancer pathogenesis and treatment. Nat Rev Cancer. 2004 Aug; 4(8):604-16. PMID: 15286740.
      Citations:    
    329. Futerman AH, Hannun YA, Futerman AH, Hannun YA. The complex life of simple sphingolipids. EMBO Rep. 2004 Aug; 5(8):777-82. PMID: 15289826; PMCID: PMC1299119.
      Citations:    
    330. Pettus BJ, Chalfant CE, Hannun YA, Pettus BJ, Chalfant CE, Hannun YA. Sphingolipids in inflammation: roles and implications. Curr Mol Med. 2004 Jun; 4(4):405-18. PMID: 15354871.
      Citations:    
    331. Becker KP, Hannun YA, Becker KP, Hannun YA. Isoenzyme-specific translocation of protein kinase C (PKC)betaII and not PKCbetaI to a juxtanuclear subset of recycling endosomes: involvement of phospholipase D. J Biol Chem. 2004 Jul 02; 279(27):28251-6. PMID: 15067001.
      Citations:    
    332. Marchesini N, Osta W, Bielawski J, Luberto C, Obeid LM, Hannun YA, Marchesini N, Osta W, Bielawski J, Luberto C, Obeid LM, Hannun YA. Role for mammalian neutral sphingomyelinase 2 in confluence-induced growth arrest of MCF7 cells. J Biol Chem. 2004 Jun 11; 279(24):25101-11. PMID: 15051724.
      Citations:    
    333. Heung LJ, Luberto C, Plowden A, Hannun YA, Del Poeta M, Heung LJ, Luberto C, Plowden A, Hannun YA, Del Poeta M. The sphingolipid pathway regulates Pkc1 through the formation of diacylglycerol in Cryptococcus neoformans. J Biol Chem. 2004 May 14; 279(20):21144-53. PMID: 15014071.
      Citations:    
    334. Taha TA, Osta W, Kozhaya L, Bielawski J, Johnson KR, Gillanders WE, Dbaibo GS, Hannun YA, Obeid LM, Taha TA, Osta W, Kozhaya L, Bielawski J, Johnson KR, Gillanders WE, Dbaibo GS, Hannun YA, Obeid LM. Down-regulation of sphingosine kinase-1 by DNA damage: dependence on proteases and p53. J Biol Chem. 2004 May 07; 279(19):20546-54. PMID: 14988393.
      Citations: 54     Fields:    Translation:HumansCells
    335. Hannun YA, Luberto C, Hannun YA, Luberto C. Lipid metabolism: ceramide transfer protein adds a new dimension. Curr Biol. 2004 Feb 17; 14(4):R163-5. PMID: 15027471.
      Citations:    
    336. Bai A, Meier GP, Wang Y, Luberto C, Hannun YA, Zhou D, Bai A, Meier GP, Wang Y, Luberto C, Hannun YA, Zhou D. Prodrug modification increases potassium tricyclo[5.2.1.0(2,6)]-decan-8-yl dithiocarbonate (D609) chemical stability and cytotoxicity against U937 leukemia cells. J Pharmacol Exp Ther. 2004 Jun; 309(3):1051-9. PMID: 14960662.
      Citations: 11     Fields:    Translation:HumansCells
    337. Alvarez-Vasquez F, Sims KJ, Hannun YA, Voit EO, Alvarez-Vasquez F, Sims KJ, Hannun YA, Voit EO. Integration of kinetic information on yeast sphingolipid metabolism in dynamical pathway models. J Theor Biol. 2004 Feb 07; 226(3):265-91. PMID: 14643642.
      Citations: 24     Fields:    Translation:AnimalsCells
    338. Marchesini N, Hannun YA, Marchesini N, Hannun YA. Acid and neutral sphingomyelinases: roles and mechanisms of regulation. Biochem Cell Biol. 2004 Feb; 82(1):27-44. PMID: 15052326.
      Citations:    
    339. Meng A, Luberto C, Meier P, Bai A, Yang X, Hannun YA, Zhou D, Meng A, Luberto C, Meier P, Bai A, Yang X, Hannun YA, Zhou D. Sphingomyelin synthase as a potential target for D609-induced apoptosis in U937 human monocytic leukemia cells. Exp Cell Res. 2004 Jan 15; 292(2):385-92. PMID: 14697345.
      Citations: 38     Fields:    Translation:HumansCells
    340. Pettus BJ, Kroesen BJ, Szulc ZM, Bielawska A, Bielawski J, Hannun YA, Busman M, Pettus BJ, Kroesen BJ, Szulc ZM, Bielawska A, Bielawski J, Hannun YA, Busman M. Quantitative measurement of different ceramide species from crude cellular extracts by normal-phase high-performance liquid chromatography coupled to atmospheric pressure ionization mass spectrometry. Rapid Commun Mass Spectrom. 2004; 18(5):577-83. PMID: 14978803.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    341. Pettus BJ, Baes M, Busman M, Hannun YA, Van Veldhoven PP, Pettus BJ, Baes M, Busman M, Hannun YA, Van Veldhoven PP. Mass spectrometric analysis of ceramide perturbations in brain and fibroblasts of mice and human patients with peroxisomal disorders. Rapid Commun Mass Spectrom. 2004; 18(14):1569-74. PMID: 15282781.
      Citations:    
    342. Vaena de Avalos S, Okamoto Y, Hannun YA, Vaena de Avalos S, Okamoto Y, Hannun YA. Activation and localization of inositol phosphosphingolipid phospholipase C, Isc1p, to the mitochondria during growth of Saccharomyces cerevisiae. J Biol Chem. 2004 Mar 19; 279(12):11537-45. PMID: 14699160.
      Citations: 37     Fields:    Translation:AnimalsCells
    343. Orr RK, Hoehn JL, Col NF, Pettus BJ, Bielawska A, Subramanian P, Wijesinghe DS, Maceyka M, Leslie CC, Evans JH, Freiberg J, Roddy P, Hannun YA, Chalfant CE. Ceramide 1-phosphate is a direct activator of cytosolic phospholipase A2. J Biol Chem. 2004 Mar 19; 279(12):11320-6. PMID: 14676210.
      Citations: 115     Fields:    Translation:HumansCells
    344. Chalfant CE, Szulc Z, Roddy P, Bielawska A, Hannun YA, Chalfant CE, Szulc Z, Roddy P, Bielawska A, Hannun YA. The structural requirements for ceramide activation of serine-threonine protein phosphatases. J Lipid Res. 2004 Mar; 45(3):496-506. PMID: 14657198.
      Citations: 59     Fields:    Translation:HumansCells
    345. Sundararaj KP, Wood RE, Ponnusamy S, Salas AM, Szulc Z, Bielawska A, Obeid LM, Hannun YA, Ogretmen B, Sundararaj KP, Wood RE, Ponnusamy S, Salas AM, Szulc Z, Bielawska A, Obeid LM, Hannun YA, Ogretmen B. Rapid shortening of telomere length in response to ceramide involves the inhibition of telomere binding activity of nuclear glyceraldehyde-3-phosphate dehydrogenase. J Biol Chem. 2004 Feb 13; 279(7):6152-62. PMID: 14630908.
      Citations: 45     Fields:    Translation:HumansCells
    346. Becker KP, Hannun YA, Becker KP, Hannun YA. cPKC-dependent sequestration of membrane-recycling components in a subset of recycling endosomes. J Biol Chem. 2003 Dec 26; 278(52):52747-54. PMID: 14527960.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    347. Obeid LM, Hannun YA, Obeid LM, Hannun YA. Ceramide, stress, and a "LAG" in aging. Sci Aging Knowledge Environ. 2003 Oct 01; 2003(39):PE27. PMID: 14523222.
      Citations: 21     Fields:    Translation:HumansAnimals
    348. Luberto C, Martinez-Mariño B, Taraskiewicz D, Bolaños B, Chitano P, Toffaletti DL, Cox GM, Perfect JR, Hannun YA, Balish E, Del Poeta M, Luberto C, Martinez-Mari?o B, Taraskiewicz D, Bola?os B, Chitano P, Toffaletti DL, Cox GM, Perfect JR, Hannun YA, Balish E, Del Poeta M. Identification of App1 as a regulator of phagocytosis and virulence of Cryptococcus neoformans. J Clin Invest. 2003 Oct; 112(7):1080-94. PMID: 14523045; PMCID: PMC198528.
      Citations: 79     Fields:    Translation:AnimalsCells
    349. Pettus BJ, Bielawski J, Porcelli AM, Reames DL, Johnson KR, Morrow J, Chalfant CE, Obeid LM, Hannun YA, Pettus BJ, Bielawski J, Porcelli AM, Reames DL, Johnson KR, Morrow J, Chalfant CE, Obeid LM, Hannun YA. The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha. FASEB J. 2003 Aug; 17(11):1411-21. PMID: 12890694.
      Citations: 123     Fields:    Translation:HumansAnimalsCells
    350. Pettus BJ, Bielawska A, Spiegel S, Roddy P, Hannun YA, Chalfant CE, Pettus BJ, Bielawska A, Spiegel S, Roddy P, Hannun YA, Chalfant CE. Ceramide kinase mediates cytokine- and calcium ionophore-induced arachidonic acid release. J Biol Chem. 2003 Oct 03; 278(40):38206-13. PMID: 12855693.
      Citations: 69     Fields:    Translation:HumansAnimalsCells
    351. Okamoto Y, Vaena de Avalos S, Hannun YA, Okamoto Y, Vaena de Avalos S, Hannun YA. Functional analysis of ISC1 by site-directed mutagenesis. Biochemistry. 2003 Jul 01; 42(25):7855-62. PMID: 12820895.
      Citations: 17     Fields:    Translation:Cells
    352. Luberto C, Stonehouse MJ, Collins EA, Marchesini N, El-Bawab S, Vasil AI, Vasil ML, Hannun YA, Luberto C, Stonehouse MJ, Collins EA, Marchesini N, El-Bawab S, Vasil AI, Vasil ML, Hannun YA. Purification, characterization, and identification of a sphingomyelin synthase from Pseudomonas aeruginosa. PlcH is a multifunctional enzyme. J Biol Chem. 2003 Aug 29; 278(35):32733-43. PMID: 12799377.
      Citations: 18     Fields:    Translation:Cells
    353. Cowart LA, Okamoto Y, Pinto FR, Gandy JL, Almeida JS, Hannun YA, Cowart LA, Okamoto Y, Pinto FR, Gandy JL, Almeida JS, Hannun YA. Roles for sphingolipid biosynthesis in mediation of specific programs of the heat stress response determined through gene expression profiling. J Biol Chem. 2003 Aug 08; 278(32):30328-38. PMID: 12740364.
      Citations: 24     Fields:    Translation:AnimalsCells
    354. Schanberg SM, Ingledue VF, Lee JY, Hannun YA, Bartolome JV, Schanberg SM, Ingledue VF, Lee JY, Hannun YA, Bartolome JV. PKC alpha mediates maternal touch regulation of growth-related gene expression in infant rats. Neuropsychopharmacology. 2003 Jun; 28(6):1026-30. PMID: 12700701.
      Citations: 10     Fields:    Translation:AnimalsCells
    355. Hyer ML, Sudarshan S, Schwartz DA, Hannun Y, Dong JY, Norris JS, Hyer ML, Sudarshan S, Schwartz DA, Hannun Y, Dong JY, Norris JS. Quantification and characterization of the bystander effect in prostate cancer cells following adenovirus-mediated FasL expression. Cancer Gene Ther. 2003 Apr; 10(4):330-9. PMID: 12679806.
      Citations: 8     Fields:    Translation:HumansCells
    356. Kroesen BJ, Jacobs S, Pettus BJ, Sietsma H, Kok JW, Hannun YA, de Leij LF, Kroesen BJ, Jacobs S, Pettus BJ, Sietsma H, Kok JW, Hannun YA, de Leij LF. BcR-induced apoptosis involves differential regulation of C16 and C24-ceramide formation and sphingolipid-dependent activation of the proteasome. J Biol Chem. 2003 Apr 25; 278(17):14723-31. PMID: 12578840.
      Citations: 44     Fields:    Translation:HumansCells
    357. Marchesini N, Luberto C, Hannun YA, Marchesini N, Luberto C, Hannun YA. Biochemical properties of mammalian neutral sphingomyelinase 2 and its role in sphingolipid metabolism. J Biol Chem. 2003 Apr 18; 278(16):13775-83. PMID: 12566438.
      Citations: 80     Fields:    Translation:HumansAnimalsCells
    358. Sato M, Markiewicz M, Yamanaka M, Bielawska A, Mao C, Obeid LM, Hannun YA, Trojanowska M, Sato M, Markiewicz M, Yamanaka M, Bielawska A, Mao C, Obeid LM, Hannun YA, Trojanowska M. Modulation of transforming growth factor-beta (TGF-beta) signaling by endogenous sphingolipid mediators. J Biol Chem. 2003 Mar 14; 278(11):9276-82. PMID: 12515830.
      Citations: 21     Fields:    Translation:HumansCells
    359. Pettus BJ, Bielawska A, Kroesen BJ, Moeller PD, Szulc ZM, Hannun YA, Busman M, Pettus BJ, Bielawska A, Kroesen BJ, Moeller PD, Szulc ZM, Hannun YA, Busman M. Observation of different ceramide species from crude cellular extracts by normal-phase high-performance liquid chromatography coupled to atmospheric pressure chemical ionization mass spectrometry. Rapid Commun Mass Spectrom. 2003; 17(11):1203-11. PMID: 12772277.
      Citations: 10     Fields:    Translation:Cells
    360. Pettus BJ, Chalfant CE, Hannun YA, Pettus BJ, Chalfant CE, Hannun YA. Ceramide in apoptosis: an overview and current perspectives. Biochim Biophys Acta. 2002 Dec 30; 1585(2-3):114-25. PMID: 12531544.
      Citations: 227     Fields:    Translation:HumansAnimals
    361. Luberto C, Hassler DF, Signorelli P, Okamoto Y, Sawai H, Boros E, Hazen-Martin DJ, Obeid LM, Hannun YA, Smith GK, Luberto C, Hassler DF, Signorelli P, Okamoto Y, Sawai H, Boros E, Hazen-Martin DJ, Obeid LM, Hannun YA, Smith GK. Inhibition of tumor necrosis factor-induced cell death in MCF7 by a novel inhibitor of neutral sphingomyelinase. J Biol Chem. 2002 Oct 25; 277(43):41128-39. PMID: 12154098.
      Citations: 137     Fields:    Translation:HumansAnimalsCells
    362. Johnson KR, Becker KP, Facchinetti MM, Hannun YA, Obeid LM, Johnson KR, Becker KP, Facchinetti MM, Hannun YA, Obeid LM. PKC-dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. Extracellular release of sphingosine-1-phosphate induced by phorbol 12-myristate 13-acetate (PMA). J Biol Chem. 2002 Sep 20; 277(38):35257-62. PMID: 12124383.
      Citations: 100     Fields:    Translation:HumansCells
    363. Hannun YA, Obeid LM, Hannun YA, Obeid LM. The Ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind. J Biol Chem. 2002 Jul 19; 277(29):25847-50. PMID: 12011103.
      Citations: 304     Fields:    Translation:AnimalsCells
    364. Jones JA, Hannun YA, Jones JA, Hannun YA. Tight binding inhibition of protein phosphatase-1 by phosphatidic acid. Specificity of inhibition by the phospholipid. J Biol Chem. 2002 May 03; 277(18):15530-8. PMID: 11856740.
      Citations: 25     Fields:    Translation:HumansCells
    365. Ogretmen B, Pettus BJ, Rossi MJ, Wood R, Usta J, Szulc Z, Bielawska A, Obeid LM, Hannun YA, Ogretmen B, Pettus BJ, Rossi MJ, Wood R, Usta J, Szulc Z, Bielawska A, Obeid LM, Hannun YA. Biochemical mechanisms of the generation of endogenous long chain ceramide in response to exogenous short chain ceramide in the A549 human lung adenocarcinoma cell line. Role for endogenous ceramide in mediating the action of exogenous ceramide. J Biol Chem. 2002 Apr 12; 277(15):12960-9. PMID: 11815611.
      Citations: 94     Fields:    Translation:HumansCells
    366. Chalfant CE, Rathman K, Pinkerman RL, Wood RE, Obeid LM, Ogretmen B, Hannun YA, Chalfant CE, Rathman K, Pinkerman RL, Wood RE, Obeid LM, Ogretmen B, Hannun YA. De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1. J Biol Chem. 2002 Apr 12; 277(15):12587-95. PMID: 11801602.
      Citations: 125     Fields:    Translation:HumansCells
    367. Orr RK, Hoehn JL, Col NF, El Bawab S, Usta J, Roddy P, Szulc ZM, Bielawska A, Hannun YA. Substrate specificity of rat brain ceramidase. J Lipid Res. 2002 Jan; 43(1):141-8. PMID: 11792733.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    368. Birbes H, El Bawab S, Obeid LM, Hannun YA, Birbes H, El Bawab S, Obeid LM, Hannun YA. Mitochondria and ceramide: intertwined roles in regulation of apoptosis. Adv Enzyme Regul. 2002; 42:113-29. PMID: 12123710.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    369. Argraves KM, Obeid LM, Hannun YA, Argraves KM, Obeid LM, Hannun YA. Sphingolipids in vascular biology. Adv Exp Med Biol. 2002; 507:439-44. PMID: 12664623.
      Citations: 8     Fields:    Translation:HumansAnimals
    370. Birbes H, El Bawab S, Hannun YA, Obeid LM, Birbes H, El Bawab S, Hannun YA, Obeid LM. Selective hydrolysis of a mitochondrial pool of sphingomyelin induces apoptosis. FASEB J. 2001 Dec; 15(14):2669-79. PMID: 11726543.
      Citations: 80     Fields:    Translation:HumansCells
    371. Ogretmen B, Hannun YA, Ogretmen B, Hannun YA. Updates on functions of ceramide in chemotherapy-induced cell death and in multidrug resistance. Drug Resist Updat. 2001 Dec; 4(6):368-77. PMID: 12030784.
      Citations: 30     Fields:    Translation:Humans
    372. Bielawska A, Perry DK, Hannun YA, Bielawska A, Perry DK, Hannun YA. Determination of ceramides and diglycerides by the diglyceride kinase assay. Anal Biochem. 2001 Nov 15; 298(2):141-50. PMID: 11757501.
      Citations: 28     Fields:    Translation:HumansAnimals
    373. Chung N, Mao C, Heitman J, Hannun YA, Obeid LM, Chung N, Mao C, Heitman J, Hannun YA, Obeid LM. Phytosphingosine as a specific inhibitor of growth and nutrient import in Saccharomyces cerevisiae. J Biol Chem. 2001 Sep 21; 276(38):35614-21. PMID: 11468289.
      Citations: 39     Fields:    Translation:Animals
    374. Boujaoude LC, Bradshaw-Wilder C, Mao C, Cohn J, Ogretmen B, Hannun YA, Obeid LM, Boujaoude LC, Bradshaw-Wilder C, Mao C, Cohn J, Ogretmen B, Hannun YA, Obeid LM. Cystic fibrosis transmembrane regulator regulates uptake of sphingoid base phosphates and lysophosphatidic acid: modulation of cellular activity of sphingosine 1-phosphate. J Biol Chem. 2001 Sep 21; 276(38):35258-64. PMID: 11443135.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
    375. Ogretmen B, Kraveka JM, Schady D, Usta J, Hannun YA, Obeid LM, Ogretmen B, Kraveka JM, Schady D, Usta J, Hannun YA, Obeid LM. Molecular mechanisms of ceramide-mediated telomerase inhibition in the A549 human lung adenocarcinoma cell line. J Biol Chem. 2001 Aug 31; 276(35):32506-14. PMID: 11441001.
      Citations: 29     Fields:    Translation:HumansCells
    376. Ogretmen B, Schady D, Usta J, Wood R, Kraveka JM, Luberto C, Birbes H, Hannun YA, Obeid LM, Ogretmen B, Schady D, Usta J, Wood R, Kraveka JM, Luberto C, Birbes H, Hannun YA, Obeid LM. Role of ceramide in mediating the inhibition of telomerase activity in A549 human lung adenocarcinoma cells. J Biol Chem. 2001 Jul 06; 276(27):24901-10. PMID: 11335714.
      Citations: 34     Fields:    Translation:HumansCells
    377. Hannun YA, Luberto C, Argraves KM, Hannun YA, Luberto C, Argraves KM. Enzymes of sphingolipid metabolism: from modular to integrative signaling. Biochemistry. 2001 Apr 24; 40(16):4893-903. PMID: 11305904.
      Citations: 139     Fields:    Translation:HumansAnimalsCells
    378. El Bawab S, Birbes H, Roddy P, Szulc ZM, Bielawska A, Hannun YA, El Bawab S, Birbes H, Roddy P, Szulc ZM, Bielawska A, Hannun YA. Biochemical characterization of the reverse activity of rat brain ceramidase. A CoA-independent and fumonisin B1-insensitive ceramide synthase. J Biol Chem. 2001 May 18; 276(20):16758-66. PMID: 11278489.
      Citations: 31     Fields:    Translation:HumansAnimals
    379. Kroesen BJ, Pettus B, Luberto C, Busman M, Sietsma H, de Leij L, Hannun YA, Kroesen BJ, Pettus B, Luberto C, Busman M, Sietsma H, de Leij L, Hannun YA. Induction of apoptosis through B-cell receptor cross-linking occurs via de novo generated C16-ceramide and involves mitochondria. J Biol Chem. 2001 Apr 27; 276(17):13606-14. PMID: 11278517.
      Citations: 41     Fields:    Translation:HumansCells
    380. Luberto C, Toffaletti DL, Wills EA, Tucker SC, Casadevall A, Perfect JR, Hannun YA, Del Poeta M, Luberto C, Toffaletti DL, Wills EA, Tucker SC, Casadevall A, Perfect JR, Hannun YA, Del Poeta M. Roles for inositol-phosphoryl ceramide synthase 1 (IPC1) in pathogenesis of C. neoformans. Genes Dev. 2001 Jan 15; 15(2):201-12. PMID: 11157776; PMCID: PMC312614.
      Citations: 77     Fields:    Translation:HumansAnimalsCells
    381. Sawai H, Okamoto Y, Luberto C, Mao C, Bielawska A, Domae N, Hannun YA, Sawai H, Okamoto Y, Luberto C, Mao C, Bielawska A, Domae N, Hannun YA. Identification of ISC1 (YER019w) as inositol phosphosphingolipid phospholipase C in Saccharomyces cerevisiae. J Biol Chem. 2000 Dec 15; 275(50):39793-8. PMID: 11006294.
      Citations: 72     Fields:    Translation:AnimalsCells
    382. Jenkins GM, Hannun YA, Jenkins GM, Hannun YA. Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae. J Biol Chem. 2001 Mar 16; 276(11):8574-81. PMID: 11056159.
      Citations: 41     Fields:    Translation:Animals
    383. Lee JY, Hannun YA, Obeid LM, Lee JY, Hannun YA, Obeid LM. Functional dichotomy of protein kinase C (PKC) in tumor necrosis factor-alpha (TNF-alpha ) signal transduction in L929 cells. Translocation and inactivation of PKC by TNF-alpha. J Biol Chem. 2000 Sep 22; 275(38):29290-8. PMID: 10887171.
      Citations: 9     Fields:    Translation:AnimalsCells
    384. El Bawab S, Roddy P, Qian T, Bielawska A, Lemasters JJ, Hannun YA, El Bawab S, Roddy P, Qian T, Bielawska A, Lemasters JJ, Hannun YA. Molecular cloning and characterization of a human mitochondrial ceramidase. J Biol Chem. 2000 Jul 14; 275(28):21508-13. PMID: 10781606.
      Citations: 77     Fields:    Translation:HumansAnimalsCells
    385. Chung N, Jenkins G, Hannun YA, Heitman J, Obeid LM, Chung N, Jenkins G, Hannun YA, Heitman J, Obeid LM. Sphingolipids signal heat stress-induced ubiquitin-dependent proteolysis. J Biol Chem. 2000 Jun 09; 275(23):17229-32. PMID: 10764732.
      Citations: 39     Fields:    Translation:AnimalsCells
    386. Feng X, Becker KP, Stribling SD, Peters KG, Hannun YA, Feng X, Becker KP, Stribling SD, Peters KG, Hannun YA. Regulation of receptor-mediated protein kinase C membrane trafficking by autophosphorylation. J Biol Chem. 2000 Jun 02; 275(22):17024-34. PMID: 10828076.
      Citations: 18     Fields:    Translation:HumansCells
    387. Bae SS, Perry DK, Oh YS, Choi JH, Galadari SH, Ghayur T, Ryu SH, Hannun YA, Suh PG, Bae SS, Perry DK, Oh YS, Choi JH, Galadari SH, Ghayur T, Ryu SH, Hannun YA, Suh PG. Proteolytic cleavage of phospholipase C-gamma1 during apoptosis in Molt-4 cells. FASEB J. 2000 Jun; 14(9):1083-92. PMID: 10834929.
      Citations: 14     Fields:    Translation:AnimalsCells
    388. Luberto C, Yoo DS, Suidan HS, Bartoli GM, Hannun YA, Luberto C, Yoo DS, Suidan HS, Bartoli GM, Hannun YA. Differential effects of sphingomyelin hydrolysis and resynthesis on the activation of NF-kappa B in normal and SV40-transformed human fibroblasts. J Biol Chem. 2000 May 12; 275(19):14760-6. PMID: 10799564.
      Citations: 18     Fields:    Translation:HumansCells
    389. Perry DK, Carton J, Shah AK, Meredith F, Uhlinger DJ, Hannun YA, Perry DK, Carton J, Shah AK, Meredith F, Uhlinger DJ, Hannun YA. Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis. J Biol Chem. 2000 Mar 24; 275(12):9078-84. PMID: 10722759.
      Citations: 86     Fields:    Translation:HumansCells
    390. Van Tiel CM, Luberto C, Snoek GT, Hannun YA, Wirtz KW, Van Tiel CM, Luberto C, Snoek GT, Hannun YA, Wirtz KW. Rapid replenishment of sphingomyelin in the plasma membrane upon degradation by sphingomyelinase in NIH3T3 cells overexpressing the phosphatidylinositol transfer protein beta. Biochem J. 2000 Mar 01; 346 Pt 2:537-43. PMID: 10677376; PMCID: PMC1220883.
      Citations: 6     Fields:    Translation:AnimalsCells
    391. Hannun YA, Luberto C, Hannun YA, Luberto C. Ceramide in the eukaryotic stress response. Trends Cell Biol. 2000 Feb; 10(2):73-80. PMID: 10652518.
      Citations: 170     Fields:    Translation:HumansAnimalsCells
    392. Smith ER, Merrill AH, Obeid LM, Hannun YA, Smith ER, Merrill AH, Obeid LM, Hannun YA. Effects of sphingosine and other sphingolipids on protein kinase C. Methods Enzymol. 2000; 312:361-73. PMID: 11070884.
      Citations: 20     Fields:    Translation:AnimalsCells
    393. Luberto C, Hannun YA, Luberto C, Hannun YA. Use of short-chain ceramides. Methods Enzymol. 2000; 312:407-20. PMID: 11070889.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    394. Liu B, Hannun YA, Liu B, Hannun YA. Purification of rat brain membrane neutral sphingomyelinase. Methods Enzymol. 2000; 311:156-64. PMID: 10563320.
      Citations: 2     Fields:    Translation:Animals
    395. Liu B, Hannun YA, Liu B, Hannun YA. Sphingomyelinase assay using radiolabeled substrate. Methods Enzymol. 2000; 311:164-7. PMID: 10563321.
      Citations: 11     Fields:    
    396. Bielawska A, Szulc Z, Hannun YA, Bielawska A, Szulc Z, Hannun YA. Synthesis of key precursors of radiolabeled sphingolipids. Methods Enzymol. 2000; 311:518-35. PMID: 10563347.
      Citations: 3     Fields:    
    397. Bielawska A, Hannun YA, Bielawska A, Hannun YA. Preparation of radiolabeled ceramides and phosphosphingolipids. Methods Enzymol. 2000; 311:499-518. PMID: 10563346.
      Citations: 2     Fields:    
    398. Perry DK, Bielawska A, Hannun YA, Perry DK, Bielawska A, Hannun YA. Quantitative determination of ceramide using diglyceride kinase. Methods Enzymol. 2000; 312:22-31. PMID: 11070860.
      Citations: 24     Fields:    Translation:AnimalsCells
    399. Chalfant CE, Kishikawa K, Bielawska A, Hannun YA, Chalfant CE, Kishikawa K, Bielawska A, Hannun YA. Analysis of ceramide-activated protein phosphatases. Methods Enzymol. 2000; 312:420-8. PMID: 11070890.
      Citations: 5     Fields:    Translation:Animals
    400. Sawai H, Domae N, Nagan N, Hannun YA, Sawai H, Domae N, Nagan N, Hannun YA. Function of the cloned putative neutral sphingomyelinase as lyso-platelet activating factor-phospholipase C. J Biol Chem. 1999 Dec 31; 274(53):38131-9. PMID: 10608884.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    401. Juo P, Woo MS, Kuo CJ, Signorelli P, Biemann HP, Hannun YA, Blenis J, Juo P, Woo MS, Kuo CJ, Signorelli P, Biemann HP, Hannun YA, Blenis J. FADD is required for multiple signaling events downstream of the receptor Fas. Cell Growth Differ. 1999 Dec; 10(12):797-804. PMID: 10616904.
      Citations: 52     Fields:    Translation:HumansCells
    402. Sawai H, Hannun YA, Sawai H, Hannun YA. Ceramide and sphingomyelinases in the regulation of stress responses. Chem Phys Lipids. 1999 Nov; 102(1-2):141-7. PMID: 11001568.
      Citations: 18     Fields:    Translation:HumansAnimals
    403. El Bawab S, Bielawska A, Hannun YA, El Bawab S, Bielawska A, Hannun YA. Purification and characterization of a membrane-bound nonlysosomal ceramidase from rat brain. J Biol Chem. 1999 Sep 24; 274(39):27948-55. PMID: 10488143.
      Citations: 23     Fields:    Translation:AnimalsCells
    404. Kishikawa K, Chalfant CE, Perry DK, Bielawska A, Hannun YA, Kishikawa K, Chalfant CE, Perry DK, Bielawska A, Hannun YA. Phosphatidic acid is a potent and selective inhibitor of protein phosphatase 1 and an inhibitor of ceramide-mediated responses. J Biol Chem. 1999 Jul 23; 274(30):21335-41. PMID: 10409693.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    405. Chalfant CE, Kishikawa K, Mumby MC, Kamibayashi C, Bielawska A, Hannun YA, Chalfant CE, Kishikawa K, Mumby MC, Kamibayashi C, Bielawska A, Hannun YA. Long chain ceramides activate protein phosphatase-1 and protein phosphatase-2A. Activation is stereospecific and regulated by phosphatidic acid. J Biol Chem. 1999 Jul 16; 274(29):20313-7. PMID: 10400653.
      Citations: 117     Fields:    Translation:Cells
    406. Zhang J, Hannun YA, Obeid LM, Zhang J, Hannun YA, Obeid LM. A novel assay for apoptotic body formation and membrane release during apoptosis. Cell Death Differ. 1999 Jul; 6(7):596-8. PMID: 10515704.
      Citations: 1     Fields:    Translation:HumansCells
    407. Kolesnick R, Hannun YA, Kolesnick R, Hannun YA. Ceramide and apoptosis. Trends Biochem Sci. 1999 Jun; 24(6):224-5; author reply 227. PMID: 10366847.
      Citations: 64     Fields:    Translation:HumansAnimals
    408. Perry DK, Hannun YA, Perry DK, Hannun YA. The use of diglyceride kinase for quantifying ceramide. Trends Biochem Sci. 1999 Jun; 24(6):226-7. PMID: 10366848.
      Citations: 8     Fields:    
    409. Zhang J, Reedy MC, Hannun YA, Obeid LM, Zhang J, Reedy MC, Hannun YA, Obeid LM. Inhibition of caspases inhibits the release of apoptotic bodies: Bcl-2 inhibits the initiation of formation of apoptotic bodies in chemotherapeutic agent-induced apoptosis. J Cell Biol. 1999 Apr 05; 145(1):99-108. PMID: 10189371; PMCID: PMC2148221.
      Citations: 19     Fields:    Translation:Cells
    410. Luberto C, Hannun YA, Luberto C, Hannun YA. Sphingolipid metabolism in the regulation of bioactive molecules. Lipids. 1999; 34 Suppl:S5-11. PMID: 10419081.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    411. Liu B, Hassler DF, Smith GK, Weaver K, Hannun YA, Liu B, Hassler DF, Smith GK, Weaver K, Hannun YA. Purification and characterization of a membrane bound neutral pH optimum magnesium-dependent and phosphatidylserine-stimulated sphingomyelinase from rat brain. J Biol Chem. 1998 Dec 18; 273(51):34472-9. PMID: 9852115.
      Citations: 27     Fields:    Translation:AnimalsCells
    412. Perry DK, Hannun YA, Perry DK, Hannun YA. The role of ceramide in cell signaling. Biochim Biophys Acta. 1998 Dec 08; 1436(1-2):233-43. PMID: 9838138.
      Citations: 63     Fields:    Translation:HumansAnimalsCells
    413. Feng X, Hannun YA, Feng X, Hannun YA. An essential role for autophosphorylation in the dissociation of activated protein kinase C from the plasma membrane. J Biol Chem. 1998 Oct 09; 273(41):26870-4. PMID: 9756933.
      Citations: 25     Fields:    Translation:HumansCells
    414. Dbaibo GS, Hannun YA, Dbaibo GS, Hannun YA. Signal transduction and the regulation of apoptosis: roles of ceramide. Apoptosis. 1998 Oct; 3(5):317-34. PMID: 14646479.
      Citations: 12     Fields:    
    415. Zhang J, Driscoll TA, Hannun YA, Obeid LM, Zhang J, Driscoll TA, Hannun YA, Obeid LM. Regulation of membrane release in apoptosis. Biochem J. 1998 Sep 01; 334 ( Pt 2):479-85. PMID: 9716508; PMCID: PMC1219712.
      Citations: 6     Fields:    Translation:HumansCells
    416. Galadari S, Kishikawa K, Kamibayashi C, Mumby MC, Hannun YA, Galadari S, Kishikawa K, Kamibayashi C, Mumby MC, Hannun YA. Purification and characterization of ceramide-activated protein phosphatases. Biochemistry. 1998 Aug 11; 37(32):11232-8. PMID: 9698369.
      Citations: 19     Fields:    Translation:AnimalsCells
    417. Dbaibo GS, Pushkareva MY, Rachid RA, Alter N, Smyth MJ, Obeid LM, Hannun YA, Dbaibo GS, Pushkareva MY, Rachid RA, Alter N, Smyth MJ, Obeid LM, Hannun YA. p53-dependent ceramide response to genotoxic stress. J Clin Invest. 1998 Jul 15; 102(2):329-39. PMID: 9664074; PMCID: PMC508891.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    418. Perry SW, Hamilton JA, Tjoelker LW, Dbaibo G, Dzenko KA, Epstein LG, Hannun Y, Whittaker JS, Dewhurst S, Gelbard HA, Perry SW, Hamilton JA, Tjoelker LW, Dbaibo G, Dzenko KA, Epstein LG, Hannun Y, Whittaker JS, Dewhurst S, Gelbard HA. Platelet-activating factor receptor activation. An initiator step in HIV-1 neuropathogenesis. J Biol Chem. 1998 Jul 10; 273(28):17660-4. PMID: 9651362.
      Citations: 38     Fields:    Translation:HumansCells
    419. Luberto C, Hannun YA, Luberto C, Hannun YA. Sphingomyelin synthase, a potential regulator of intracellular levels of ceramide and diacylglycerol during SV40 transformation. Does sphingomyelin synthase account for the putative phosphatidylcholine-specific phospholipase C? J Biol Chem. 1998 Jun 05; 273(23):14550-9. PMID: 9603970.
      Citations: 85     Fields:    Translation:HumansCells
    420. Laethem RM, Hannun YA, Jayadev S, Sexton CJ, Strum JC, Sundseth R, Smith GK, Laethem RM, Hannun YA, Jayadev S, Sexton CJ, Strum JC, Sundseth R, Smith GK. Increases in neutral, Mg2+-dependent and acidic, Mg2+-independent sphingomyelinase activities precede commitment to apoptosis and are not a consequence of caspase 3-like activity in Molt-4 cells in response to thymidylate synthase inhibition by GW1843. Blood. 1998 Jun 01; 91(11):4350-60. PMID: 9596684.
      Citations: 4     Fields:    Translation:HumansCells
    421. Liu B, Andrieu-Abadie N, Levade T, Zhang P, Obeid LM, Hannun YA, Liu B, Andrieu-Abadie N, Levade T, Zhang P, Obeid LM, Hannun YA. Glutathione regulation of neutral sphingomyelinase in tumor necrosis factor-alpha-induced cell death. J Biol Chem. 1998 May 01; 273(18):11313-20. PMID: 9556624.
      Citations: 61     Fields:    Translation:HumansCells
    422. Feng X, Zhang J, Barak LS, Meyer T, Caron MG, Hannun YA, Feng X, Zhang J, Barak LS, Meyer T, Caron MG, Hannun YA. Visualization of dynamic trafficking of a protein kinase C betaII/green fluorescent protein conjugate reveals differences in G protein-coupled receptor activation and desensitization. J Biol Chem. 1998 Apr 24; 273(17):10755-62. PMID: 9553141.
      Citations: 19     Fields:    Translation:HumansCells
    423. Flores I, Martinez-A C, Hannun YA, Mérida I, Flores I, Martinez-A C, Hannun YA, M?rida I. Dual role of ceramide in the control of apoptosis following IL-2 withdrawal. J Immunol. 1998 Apr 01; 160(7):3528-33. PMID: 9531315.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    424. Rizzieri KE, Hannun YA, Rizzieri KE, Hannun YA. Sphingolipid metabolism, apoptosis and resistance to cytotoxic agents: can we interfere? Drug Resist Updat. 1998; 1(6):359-76. PMID: 17092818.
      Citations:    
    425. Jenkins GM, Richards A, Wahl T, Mao C, Obeid L, Hannun Y, Jenkins GM, Richards A, Wahl T, Mao C, Obeid L, Hannun Y. Involvement of yeast sphingolipids in the heat stress response of Saccharomyces cerevisiae. J Biol Chem. 1997 Dec 19; 272(51):32566-72. PMID: 9405471.
      Citations: 100     Fields:    Translation:Animals
    426. Mao C, Wadleigh M, Jenkins GM, Hannun YA, Obeid LM, Mao C, Wadleigh M, Jenkins GM, Hannun YA, Obeid LM. Identification and characterization of Saccharomyces cerevisiae dihydrosphingosine-1-phosphate phosphatase. J Biol Chem. 1997 Nov 07; 272(45):28690-4. PMID: 9353337.
      Citations: 45     Fields:    Translation:Animals
    427. Hannun YA, Obeid LM, Hannun YA, Obeid LM. Ceramide and the eukaryotic stress response. Biochem Soc Trans. 1997 Nov; 25(4):1171-5. PMID: 9449970.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    428. Bielawska AE, Shapiro JP, Jiang L, Melkonyan HS, Piot C, Wolfe CL, Tomei LD, Hannun YA, Umansky SR, Bielawska AE, Shapiro JP, Jiang L, Melkonyan HS, Piot C, Wolfe CL, Tomei LD, Hannun YA, Umansky SR. Ceramide is involved in triggering of cardiomyocyte apoptosis induced by ischemia and reperfusion. Am J Pathol. 1997 Nov; 151(5):1257-63. PMID: 9358751; PMCID: PMC1858093.
      Citations: 62     Fields:    Translation:AnimalsCells
    429. Saba JD, Nara F, Bielawska A, Garrett S, Hannun YA, Saba JD, Nara F, Bielawska A, Garrett S, Hannun YA. The BST1 gene of Saccharomyces cerevisiae is the sphingosine-1-phosphate lyase. J Biol Chem. 1997 Oct 17; 272(42):26087-90. PMID: 9334171.
      Citations: 77     Fields:    Translation:Animals
    430. Lee TG, Park JB, Lee SD, Hong S, Kim JH, Kim Y, Yi KS, Bae S, Hannun YA, Obeid LM, Suh PG, Ryu SH, Lee TG, Park JB, Lee SD, Hong S, Kim JH, Kim Y, Yi KS, Bae S, Hannun YA, Obeid LM, Suh PG, Ryu SH. Phorbol myristate acetate-dependent association of protein kinase C alpha with phospholipase D1 in intact cells. Biochim Biophys Acta. 1997 Aug 16; 1347(2-3):199-204. PMID: 9295164.
      Citations: 6     Fields:    Translation:AnimalsCells
    431. Perry DK, Smyth MJ, Stennicke HR, Salvesen GS, Duriez P, Poirier GG, Hannun YA, Perry DK, Smyth MJ, Stennicke HR, Salvesen GS, Duriez P, Poirier GG, Hannun YA. Zinc is a potent inhibitor of the apoptotic protease, caspase-3. A novel target for zinc in the inhibition of apoptosis. J Biol Chem. 1997 Jul 25; 272(30):18530-3. PMID: 9228015.
      Citations: 115     Fields:    Translation:HumansAnimalsCells
    432. Wieder T, Geilen CC, Kolter T, Sadeghlar F, Sandhoff K, Brossmer R, Ihrig P, Perry D, Orfanos CE, Hannun YA, Wieder T, Geilen CC, Kolter T, Sadeghlar F, Sandhoff K, Brossmer R, Ihrig P, Perry D, Orfanos CE, Hannun YA. Bcl-2 antagonizes apoptotic cell death induced by two new ceramide analogues. FEBS Lett. 1997 Jul 14; 411(2-3):260-4. PMID: 9271217.
      Citations: 3     Fields:    Translation:HumansCells
    433. Jayadev S, Hayter HL, Andrieu N, Gamard CJ, Liu B, Balu R, Hayakawa M, Ito F, Hannun YA, Jayadev S, Hayter HL, Andrieu N, Gamard CJ, Liu B, Balu R, Hayakawa M, Ito F, Hannun YA. Phospholipase A2 is necessary for tumor necrosis factor alpha-induced ceramide generation in L929 cells. J Biol Chem. 1997 Jul 04; 272(27):17196-203. PMID: 9202042.
      Citations: 26     Fields:    Translation:AnimalsCells
    434. Liu B, Hannun YA, Liu B, Hannun YA. Inhibition of the neutral magnesium-dependent sphingomyelinase by glutathione. J Biol Chem. 1997 Jun 27; 272(26):16281-7. PMID: 9195931.
      Citations: 59     Fields:    Translation:HumansCells
    435. Gamard CJ, Dbaibo GS, Liu B, Obeid LM, Hannun YA, Gamard CJ, Dbaibo GS, Liu B, Obeid LM, Hannun YA. Selective involvement of ceramide in cytokine-induced apoptosis. Ceramide inhibits phorbol ester activation of nuclear factor kappaB. J Biol Chem. 1997 Jun 27; 272(26):16474-81. PMID: 9195956.
      Citations: 16     Fields:    Translation:Humans
    436. Lai TS, Bielawska A, Peoples KA, Hannun YA, Greenberg CS, Lai TS, Bielawska A, Peoples KA, Hannun YA, Greenberg CS. Sphingosylphosphocholine reduces the calcium ion requirement for activating tissue transglutaminase. J Biol Chem. 1997 Jun 27; 272(26):16295-300. PMID: 9195933.
      Citations: 11     Fields:    Translation:HumansCells
    437. Wang Y, Roman R, Schlenker T, Hannun YA, Raymond J, Fitz JG, Wang Y, Roman R, Schlenker T, Hannun YA, Raymond J, Fitz JG. Cytosolic Ca2+ and protein kinase Calpha couple cellular metabolism to membrane K+ permeability in a human biliary cell line. J Clin Invest. 1997 Jun 15; 99(12):2890-7. PMID: 9185512; PMCID: PMC508140.
      Citations: 10     Fields:    Translation:HumansCells
    438. Bradham CA, Stachlewitz RF, Gao W, Qian T, Jayadev S, Jenkins G, Hannun Y, Lemasters JJ, Thurman RG, Brenner DA, Bradham CA, Stachlewitz RF, Gao W, Qian T, Jayadev S, Jenkins G, Hannun Y, Lemasters JJ, Thurman RG, Brenner DA. Reperfusion after liver transplantation in rats differentially activates the mitogen-activated protein kinases. Hepatology. 1997 May; 25(5):1128-35. PMID: 9141429.
      Citations: 48     Fields:    Translation:AnimalsCells
    439. Zhang P, Liu B, Jenkins GM, Hannun YA, Obeid LM, Zhang P, Liu B, Jenkins GM, Hannun YA, Obeid LM. Expression of neutral sphingomyelinase identifies a distinct pool of sphingomyelin involved in apoptosis. J Biol Chem. 1997 Apr 11; 272(15):9609-12. PMID: 9092485.
      Citations: 40     Fields:    Translation:AnimalsCells
    440. Dbaibo GS, Perry DK, Gamard CJ, Platt R, Poirier GG, Obeid LM, Hannun YA, Dbaibo GS, Perry DK, Gamard CJ, Platt R, Poirier GG, Obeid LM, Hannun YA. Cytokine response modifier A (CrmA) inhibits ceramide formation in response to tumor necrosis factor (TNF)-alpha: CrmA and Bcl-2 target distinct components in the apoptotic pathway. J Exp Med. 1997 Feb 03; 185(3):481-90. PMID: 9053448; PMCID: PMC2196031.
      Citations: 26     Fields:    Translation:HumansCells
    441. Puranam K, Qian WH, Nikbakht K, Venable M, Obeid L, Hannun Y, Boustany RM, Puranam K, Qian WH, Nikbakht K, Venable M, Obeid L, Hannun Y, Boustany RM. Upregulation of Bcl-2 and elevation of ceramide in Batten disease. Neuropediatrics. 1997 Feb; 28(1):37-41. PMID: 9151319.
      Citations: 18     Fields:    Translation:HumansCells
    442. Smyth MJ, Obeid LM, Hannun YA, Smyth MJ, Obeid LM, Hannun YA. Ceramide: a novel lipid mediator of apoptosis. Adv Pharmacol. 1997; 41:133-54. PMID: 9204144.
      Citations: 10     Fields:    Translation:AnimalsCells
    443. Hannun YA, Hannun YA. Sphingolipid second messengers: tumor suppressor lipids. Adv Exp Med Biol. 1997; 400A:305-12. PMID: 9547572.
      Citations: 9     Fields:    Translation:AnimalsCells
    444. Hannun YA, Obeid LM, Hannun YA, Obeid LM. Mechanisms of ceramide-mediated apoptosis. Adv Exp Med Biol. 1997; 407:145-9. PMID: 9321945.
      Citations: 12     Fields:    Translation:AnimalsCells
    445. Liu B, Maher RJ, De Jonckheere JP, Popat RU, Stojakovic S, Hannun YA, Porter AT, Honn KV, Liu B, Maher RJ, De Jonckheere JP, Popat RU, Stojakovic S, Hannun YA, Porter AT, Honn KV. 12(S)-HETE increases the motility of prostate tumor cells through selective activation of PKC alpha. Adv Exp Med Biol. 1997; 400B:707-18. PMID: 9547622.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    446. Perry DK, Smyth MJ, Wang HG, Reed JC, Duriez P, Poirier GG, Obeid LM, Hannun YA, Perry DK, Smyth MJ, Wang HG, Reed JC, Duriez P, Poirier GG, Obeid LM, Hannun YA. Bcl-2 acts upstream of the PARP protease and prevents its activation. Cell Death Differ. 1997 Jan; 4(1):29-33. PMID: 16465207.
      Citations:    
    447. Hannun YA, Hannun YA. Functions of ceramide in coordinating cellular responses to stress. Science. 1996 Dec 13; 274(5294):1855-9. PMID: 8943189.
      Citations: 354     Fields:    Translation:HumansAnimalsCells
    448. Jideama NM, Noland TA, Raynor RL, Blobe GC, Fabbro D, Kazanietz MG, Blumberg PM, Hannun YA, Kuo JF, Jideama NM, Noland TA, Raynor RL, Blobe GC, Fabbro D, Kazanietz MG, Blumberg PM, Hannun YA, Kuo JF. Phosphorylation specificities of protein kinase C isozymes for bovine cardiac troponin I and troponin T and sites within these proteins and regulation of myofilament properties. J Biol Chem. 1996 Sep 20; 271(38):23277-83. PMID: 8798526.
      Citations: 54     Fields:    Translation:AnimalsCells
    449. Jayadev S, Hannun YA, Jayadev S, Hannun YA. Ceramide: role in growth inhibitory cascades. J Lipid Mediat Cell Signal. 1996 Sep; 14(1-3):295-301. PMID: 8906575.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    450. Wang Y, Sostman A, Roman R, Stribling S, Vigna S, Hannun Y, Raymond J, Fitz JG, Wang Y, Sostman A, Roman R, Stribling S, Vigna S, Hannun Y, Raymond J, Fitz JG. Metabolic stress opens K+ channels in hepatoma cells through a Ca2+- and protein kinase calpha-dependent mechanism. J Biol Chem. 1996 Jul 26; 271(30):18107-13. PMID: 8663472.
      Citations: 9     Fields:    Translation:AnimalsCells
    451. Kawamura A, Berova N, Dirsch V, Mangoni A, Nakanishi K, Schwartz G, Bielawska A, Hannun Y, Kitagawa I, Kawamura A, Berova N, Dirsch V, Mangoni A, Nakanishi K, Schwartz G, Bielawska A, Hannun Y, Kitagawa I. Picomole scale stereochemical analysis of sphingosines and dihydrosphingosines. Bioorg Med Chem. 1996 Jul; 4(7):1035-43. PMID: 8831974.
      Citations: 4     Fields:    
    452. Perry DK, Obeid LM, Hannun YA, Perry DK, Obeid LM, Hannun YA. Ceramide and the regulation of apoptosis and the stress response. Trends Cardiovasc Med. 1996 Jul; 6(5):158-62. PMID: 21232290.
      Citations:    
    453. Blobe GC, Stribling DS, Fabbro D, Stabel S, Hannun YA, Blobe GC, Stribling DS, Fabbro D, Stabel S, Hannun YA. Protein kinase C beta II specifically binds to and is activated by F-actin. J Biol Chem. 1996 Jun 28; 271(26):15823-30. PMID: 8663149.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    454. Linardic CM, Jayadev S, Hannun YA, Linardic CM, Jayadev S, Hannun YA. Activation of the sphingomyelin cycle by brefeldin A: effects of brefeldin A on differentiation and implications for a role for ceramide in regulation of protein trafficking. Cell Growth Differ. 1996 Jun; 7(6):765-74. PMID: 8780890.
      Citations: 4     Fields:    Translation:HumansCells
    455. Lee JY, Hannun YA, Obeid LM, Lee JY, Hannun YA, Obeid LM. Ceramide inactivates cellular protein kinase Calpha. J Biol Chem. 1996 May 31; 271(22):13169-74. PMID: 8662781.
      Citations: 46     Fields:    Translation:HumansCells
    456. Zhang J, Alter N, Reed JC, Borner C, Obeid LM, Hannun YA, Zhang J, Alter N, Reed JC, Borner C, Obeid LM, Hannun YA. Bcl-2 interrupts the ceramide-mediated pathway of cell death. Proc Natl Acad Sci U S A. 1996 May 28; 93(11):5325-8. PMID: 8643573; PMCID: PMC39244.
      Citations: 56     Fields:    Translation:HumansCells
    457. Bielawska A, Greenberg MS, Perry D, Jayadev S, Shayman JA, McKay C, Hannun YA, Bielawska A, Greenberg MS, Perry D, Jayadev S, Shayman JA, McKay C, Hannun YA. (1S,2R)-D-erythro-2-(N-myristoylamino)-1-phenyl-1-propanol as an inhibitor of ceramidase. J Biol Chem. 1996 May 24; 271(21):12646-54. PMID: 8647877.
      Citations: 45     Fields:    Translation:HumansCells
    458. Smyth MJ, Perry DK, Zhang J, Poirier GG, Hannun YA, Obeid LM, Smyth MJ, Perry DK, Zhang J, Poirier GG, Hannun YA, Obeid LM. prICE: a downstream target for ceramide-induced apoptosis and for the inhibitory action of Bcl-2. Biochem J. 1996 May 15; 316 ( Pt 1):25-8. PMID: 8645213; PMCID: PMC1217330.
      Citations: 29     Fields:    Translation:HumansCells
    459. Hayakawa M, Jayadev S, Tsujimoto M, Hannun YA, Ito F, Hayakawa M, Jayadev S, Tsujimoto M, Hannun YA, Ito F. Role of ceramide in stimulation of the transcription of cytosolic phospholipase A2 and cyclooxygenase 2. Biochem Biophys Res Commun. 1996 Mar 27; 220(3):681-6. PMID: 8607825.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    460. Saba JD, Obeid LM, Hannun YA, Saba JD, Obeid LM, Hannun YA. Ceramide: an intracellular mediator of apoptosis and growth suppression. Philos Trans R Soc Lond B Biol Sci. 1996 Feb 29; 351(1336):233-40; discussion 240-1. PMID: 8650271.
      Citations: 11     Fields:    Translation:AnimalsCells
    461. Blobe GC, Stribling S, Obeid LM, Hannun YA, Blobe GC, Stribling S, Obeid LM, Hannun YA. Protein kinase C isoenzymes: regulation and function. Cancer Surv. 1996; 27:213-48. PMID: 8909803.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    462. Westwick JK, Bielawska AE, Dbaibo G, Hannun YA, Brenner DA, Westwick JK, Bielawska AE, Dbaibo G, Hannun YA, Brenner DA. Ceramide activates the stress-activated protein kinases. J Biol Chem. 1995 Sep 29; 270(39):22689-92. PMID: 7559390.
      Citations: 58     Fields:    Translation:HumansAnimalsCells
    463. Liu B, Khan WA, Hannun YA, Timar J, Taylor JD, Lundy S, Butovich I, Honn KV, Liu B, Khan WA, Hannun YA, Timar J, Taylor JD, Lundy S, Butovich I, Honn KV. 12(S)-hydroxyeicosatetraenoic acid and 13(S)-hydroxyoctadecadienoic acid regulation of protein kinase C-alpha in melanoma cells: role of receptor-mediated hydrolysis of inositol phospholipids. Proc Natl Acad Sci U S A. 1995 Sep 26; 92(20):9323-7. PMID: 7568126; PMCID: PMC40977.
      Citations: 30     Fields:    Translation:AnimalsCells
    464. Dobrowsky RT, Jenkins GM, Hannun YA, Dobrowsky RT, Jenkins GM, Hannun YA. Neurotrophins induce sphingomyelin hydrolysis. Modulation by co-expression of p75NTR with Trk receptors. J Biol Chem. 1995 Sep 22; 270(38):22135-42. PMID: 7673191.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
    465. Dbaibo GS, Wolff RA, Obeid LM, Hannun YA, Dbaibo GS, Wolff RA, Obeid LM, Hannun YA. Activation of a retinoblastoma-protein-dependent pathway by sphingosine. Biochem J. 1995 Sep 01; 310 ( Pt 2):453-9. PMID: 7654183; PMCID: PMC1135917.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    466. Orr RK, Hoehn JL, Col NF, Tepper CG, Jayadev S, Liu B, Bielawska A, Wolff R, Yonehara S, Hannun YA, Seldin MF. Role for ceramide as an endogenous mediator of Fas-induced cytotoxicity. Proc Natl Acad Sci U S A. 1995 Aug 29; 92(18):8443-7. PMID: 7545303; PMCID: PMC41173.
      Citations: 42     Fields:    Translation:Cells
    467. Laulederkind SJ, Bielawska A, Raghow R, Hannun YA, Ballou LR, Laulederkind SJ, Bielawska A, Raghow R, Hannun YA, Ballou LR. Ceramide induces interleukin 6 gene expression in human fibroblasts. J Exp Med. 1995 Aug 01; 182(2):599-604. PMID: 7629516; PMCID: PMC2192147.
      Citations: 15     Fields:    Translation:HumansCells
    468. Pushkareva M, Obeid LM, Hannun YA, Pushkareva M, Obeid LM, Hannun YA. Ceramide: an endogenous regulator of apoptosis and growth suppression. Immunol Today. 1995 Jun; 16(6):294-7. PMID: 7662099.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    469. Obeid LM, Hannun YA, Obeid LM, Hannun YA. Ceramide: a stress signal and mediator of growth suppression and apoptosis. J Cell Biochem. 1995 Jun; 58(2):191-8. PMID: 7673327.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    470. Khan WA, Blobe GC, Hannun YA, Khan WA, Blobe GC, Hannun YA. Arachidonic acid and free fatty acids as second messengers and the role of protein kinase C. Cell Signal. 1995 Mar; 7(3):171-84. PMID: 7662506.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    471. Dbaibo GS, Pushkareva MY, Jayadev S, Schwarz JK, Horowitz JM, Obeid LM, Hannun YA, Dbaibo GS, Pushkareva MY, Jayadev S, Schwarz JK, Horowitz JM, Obeid LM, Hannun YA. Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest. Proc Natl Acad Sci U S A. 1995 Feb 28; 92(5):1347-51. PMID: 7877980; PMCID: PMC42516.
      Citations: 39     Fields:    Translation:HumansCells
    472. Pushkareva M, Chao R, Bielawska A, Merrill AH, Crane HM, Lagu B, Liotta D, Hannun YA, Pushkareva M, Chao R, Bielawska A, Merrill AH, Crane HM, Lagu B, Liotta D, Hannun YA. Stereoselectivity of induction of the retinoblastoma gene product (pRb) dephosphorylation by D-erythro-sphingosine supports a role for pRb in growth suppression by sphingosine. Biochemistry. 1995 Feb 14; 34(6):1885-92. PMID: 7849048.
      Citations: 3     Fields:    Translation:Cells
    473. Jayadev S, Liu B, Bielawska AE, Lee JY, Nazaire F, Obeid LM, Hannun YA, Jayadev S, Liu B, Bielawska AE, Lee JY, Nazaire F, Obeid LM, Hannun YA. Role for ceramide in cell cycle arrest. J Biol Chem. 1995 Feb 03; 270(5):2047-52. PMID: 7836432.
      Citations: 96     Fields:    Translation:HumansCells
    474. Blobe GC, Khan WA, Hannun YA, Blobe GC, Khan WA, Hannun YA. Protein kinase C: cellular target of the second messenger arachidonic acid? Prostaglandins Leukot Essent Fatty Acids. 1995 Feb-Mar; 52(2-3):129-35. PMID: 7784448.
      Citations: 6     Fields:    Translation:HumansCells
    475. Hannun YA, Obeid LM, Hannun YA, Obeid LM. Ceramide: an intracellular signal for apoptosis. Trends Biochem Sci. 1995 Feb; 20(2):73-7. PMID: 7701566.
      Citations: 112     Fields:    Translation:HumansCells
    476. Blobe GC, Obeid LM, Hannun YA, Blobe GC, Obeid LM, Hannun YA. Regulation of protein kinase C and role in cancer biology. Cancer Metastasis Rev. 1994 Dec; 13(3-4):411-31. PMID: 7712599.
      Citations: 42     Fields:    Translation:HumansAnimals
    477. Alcantara O, Obeid L, Hannun Y, Ponka P, Boldt DH, Alcantara O, Obeid L, Hannun Y, Ponka P, Boldt DH. Regulation of protein kinase C (PKC) expression by iron: effect of different iron compounds on PKC-beta and PKC-alpha gene expression and role of the 5'-flanking region of the PKC-beta gene in the response to ferric transferrin. Blood. 1994 Nov 15; 84(10):3510-7. PMID: 7949105.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    478. Linardic CM, Hannun YA, Linardic CM, Hannun YA. Identification of a distinct pool of sphingomyelin involved in the sphingomyelin cycle. J Biol Chem. 1994 Sep 23; 269(38):23530-7. PMID: 8089120.
      Citations: 30     Fields:    Translation:HumansCells
    479. Dobrowsky RT, Werner MH, Castellino AM, Chao MV, Hannun YA, Dobrowsky RT, Werner MH, Castellino AM, Chao MV, Hannun YA. Activation of the sphingomyelin cycle through the low-affinity neurotrophin receptor. Science. 1994 Sep 09; 265(5178):1596-9. PMID: 8079174.
      Citations: 113     Fields:    Translation:AnimalsCells
    480. Liu B, Maher RJ, Hannun YA, Porter AT, Honn KV, Liu B, Maher RJ, Hannun YA, Porter AT, Honn KV. 12(S)-HETE enhancement of prostate tumor cell invasion: selective role of PKC alpha. J Natl Cancer Inst. 1994 Aug 03; 86(15):1145-51. PMID: 7518003.
      Citations: 20     Fields:    Translation:AnimalsCells
    481. Wolff RA, Dobrowsky RT, Bielawska A, Obeid LM, Hannun YA, Wolff RA, Dobrowsky RT, Bielawska A, Obeid LM, Hannun YA. Role of ceramide-activated protein phosphatase in ceramide-mediated signal transduction. J Biol Chem. 1994 Jul 29; 269(30):19605-9. PMID: 8034729.
      Citations: 61     Fields:    Translation:HumansCells
    482. Gamard CJ, Blobe GC, Hannun YA, Obeid LM, Gamard CJ, Blobe GC, Hannun YA, Obeid LM. Specific role for protein kinase C beta in cell differentiation. Cell Growth Differ. 1994 Apr; 5(4):405-9. PMID: 8043514.
      Citations: 7     Fields:    Translation:HumansCells
    483. Khan WA, Blobe GC, Richards AL, Hannun YA, Khan WA, Blobe GC, Richards AL, Hannun YA. Identification, partial purification, and characterization of a novel phospholipid-dependent and fatty acid-activated protein kinase from human platelets. J Biol Chem. 1994 Apr 01; 269(13):9729-35. PMID: 8144564.
      Citations: 11     Fields:    Translation:HumansCells
    484. Hannun YA, Hannun YA. Modulation of cytosolic protein phosphorylation by sphingosylphosphorylcholine. Biochim Biophys Acta. 1994 Mar 10; 1221(1):54-60. PMID: 8130276.
      Citations: 3     Fields:    Translation:HumansCells
    485. Jayadev S, Linardic CM, Hannun YA, Jayadev S, Linardic CM, Hannun YA. Identification of arachidonic acid as a mediator of sphingomyelin hydrolysis in response to tumor necrosis factor alpha. J Biol Chem. 1994 Feb 25; 269(8):5757-63. PMID: 8119915.
      Citations: 58     Fields:    Translation:HumansCells
    486. Okazaki T, Bielawska A, Domae N, Bell RM, Hannun YA, Okazaki T, Bielawska A, Domae N, Bell RM, Hannun YA. Characteristics and partial purification of a novel cytosolic, magnesium-independent, neutral sphingomyelinase activated in the early signal transduction of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation. J Biol Chem. 1994 Feb 11; 269(6):4070-7. PMID: 8307965.
      Citations: 39     Fields:    Translation:HumansCells
    487. Hannun YA, Hannun YA. The sphingomyelin cycle and the second messenger function of ceramide. J Biol Chem. 1994 Feb 04; 269(5):3125-8. PMID: 8106344.
      Citations: 228     Fields:    Translation:HumansAnimalsCells
    488. Ghalayini AJ, Koutz CA, Wetsel WC, Hannun YA, Anderson RE, Ghalayini AJ, Koutz CA, Wetsel WC, Hannun YA, Anderson RE. Immunolocalization of PKC zeta in rat photoreceptor inner segments. Curr Eye Res. 1994 Feb; 13(2):145-50. PMID: 8194361.
      Citations: 6     Fields:    Translation:AnimalsCells
    489. Hannun YA, Linardic CM, Hannun YA, Linardic CM. Sphingolipid breakdown products: anti-proliferative and tumor-suppressor lipids. Biochim Biophys Acta. 1993 Dec 21; 1154(3-4):223-36. PMID: 8280742.
      Citations: 57     Fields:    Translation:HumansAnimalsCells
    490. Bielawska A, Crane HM, Liotta D, Obeid LM, Hannun YA, Bielawska A, Crane HM, Liotta D, Obeid LM, Hannun YA. Selectivity of ceramide-mediated biology. Lack of activity of erythro-dihydroceramide. J Biol Chem. 1993 Dec 15; 268(35):26226-32. PMID: 8253743.
      Citations: 63     Fields:    Translation:HumansCells
    491. Bielawska A, Menaldiv D, Liotta D, Hannun YA, Bielawska A, Menaldiv D, Liotta D, Hannun YA. Regulation of sphingosine-activated protein kinases: selectivity of activation by sphingoid bases and inhibition by non-esterified fatty acids. Biochem J. 1993 Sep 15; 294 ( Pt 3):699-703. PMID: 8379926; PMCID: PMC1134519.
      Citations: 3     Fields:    Translation:HumansCells
    492. Dbaibo GS, Obeid LM, Hannun YA, Dbaibo GS, Obeid LM, Hannun YA. Tumor necrosis factor-alpha (TNF-alpha) signal transduction through ceramide. Dissociation of growth inhibitory effects of TNF-alpha from activation of nuclear factor-kappa B. J Biol Chem. 1993 Aug 25; 268(24):17762-6. PMID: 8349660.
      Citations: 39     Fields:    Translation:HumansCells
    493. Middleton JP, Khan WA, Collinsworth G, Hannun YA, Medford RM, Middleton JP, Khan WA, Collinsworth G, Hannun YA, Medford RM. Heterogeneity of protein kinase C-mediated rapid regulation of Na/K-ATPase in kidney epithelial cells. J Biol Chem. 1993 Jul 25; 268(21):15958-64. PMID: 8393456.
      Citations: 23     Fields:    Translation:AnimalsCells
    494. Dobrowsky RT, Kamibayashi C, Mumby MC, Hannun YA, Dobrowsky RT, Kamibayashi C, Mumby MC, Hannun YA. Ceramide activates heterotrimeric protein phosphatase 2A. J Biol Chem. 1993 Jul 25; 268(21):15523-30. PMID: 8393446.
      Citations: 205     Fields:    Translation:AnimalsCells
    495. Blobe GC, Khan WA, Halpern AE, Obeid LM, Hannun YA, Blobe GC, Khan WA, Halpern AE, Obeid LM, Hannun YA. Selective regulation of expression of protein kinase C beta isoenzymes occurs via alternative splicing. J Biol Chem. 1993 May 15; 268(14):10627-35. PMID: 7683684.
      Citations: 11     Fields:    Translation:HumansCells
    496. Fishbein JD, Dobrowsky RT, Bielawska A, Garrett S, Hannun YA, Fishbein JD, Dobrowsky RT, Bielawska A, Garrett S, Hannun YA. Ceramide-mediated growth inhibition and CAPP are conserved in Saccharomyces cerevisiae. J Biol Chem. 1993 May 05; 268(13):9255-61. PMID: 8387486.
      Citations: 32     Fields:    Translation:Animals
    497. Obeid LM, Linardic CM, Karolak LA, Hannun YA, Obeid LM, Linardic CM, Karolak LA, Hannun YA. Programmed cell death induced by ceramide. Science. 1993 Mar 19; 259(5102):1769-71. PMID: 8456305.
      Citations: 436     Fields:    Translation:Cells
    498. Orr RK, Hoehn JL, Col NF, Khan WA, Blobe G, Halpern A, Taylor W, Wetsel WC, Burns D, Loomis C, Hannun YA. Selective regulation of protein kinase C isoenzymes by oleic acid in human platelets. J Biol Chem. 1993 Mar 05; 268(7):5063-8. PMID: 8444883.
      Citations: 21     Fields:    Translation:HumansCells
    499. Tuominen RK, Werner MH, Ye H, McMillian MK, Hudson PM, Hannun YA, Hong JS, Tuominen RK, Werner MH, Ye H, McMillian MK, Hudson PM, Hannun YA, Hong JS. Biphasic generation of diacylglycerol by angiotensin and phorbol ester in bovine adrenal chromaffin cells. Biochem Biophys Res Commun. 1993 Jan 15; 190(1):181-5. PMID: 8380691.
      Citations: 2     Fields:    Translation:AnimalsCells
    500. Blobe GC, Sachs CW, Khan WA, Fabbro D, Stabel S, Wetsel WC, Obeid LM, Fine RL, Hannun YA, Blobe GC, Sachs CW, Khan WA, Fabbro D, Stabel S, Wetsel WC, Obeid LM, Fine RL, Hannun YA. Selective regulation of expression of protein kinase C (PKC) isoenzymes in multidrug-resistant MCF-7 cells. Functional significance of enhanced expression of PKC alpha. J Biol Chem. 1993 Jan 05; 268(1):658-64. PMID: 8093247.
      Citations: 41     Fields:    Translation:HumansCells
    501. Karolak L, Chandra A, Khan W, Marks B, Petros WP, Peters WP, Greenberg CS, Hannun YA, Karolak L, Chandra A, Khan W, Marks B, Petros WP, Peters WP, Greenberg CS, Hannun YA. High-dose chemotherapy-induced platelet defect: inhibition of platelet signal transduction pathways. Mol Pharmacol. 1993 Jan; 43(1):37-44. PMID: 8423767.
      Citations: 2     Fields:    Translation:HumansCells
    502. Merrill AH, Hannun YA, Bell RM, Merrill AH, Hannun YA, Bell RM. Introduction: sphingolipids and their metabolites in cell regulation. Adv Lipid Res. 1993; 25:1-24. PMID: 8368146.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    503. Orr RK, Hoehn JL, Col NF, Hannun YA, Obeid LM, Wolff RA. The novel second messenger ceramide: identification, mechanism of action, and cellular activity. Adv Lipid Res. 1993; 25:43-64. PMID: 8396313.
      Citations: 12     Fields:    Translation:HumansCells
    504. Dobrowsky RT, Hannun YA, Dobrowsky RT, Hannun YA. Ceramide-activated protein phosphatase: partial purification and relationship to protein phosphatase 2A. Adv Lipid Res. 1993; 25:91-104. PMID: 8396314.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    505. Hannun YA, Bell RM, Hannun YA, Bell RM. The sphingomyelin cycle: a prototypic sphingolipid signaling pathway. Adv Lipid Res. 1993; 25:27-41. PMID: 8368151.
      Citations: 10     Fields:    Translation:HumansCells
    506. Setty BN, Werner MH, Hannun YA, Stuart MJ, Setty BN, Werner MH, Hannun YA, Stuart MJ. 15-Hydroxyeicosatetraenoic acid-mediated potentiation of thrombin-induced platelet functions occurs via enhanced production of phosphoinositide-derived second messengers--sn-1,2-diacylglycerol and inositol-1,4,5-trisphosphate. Blood. 1992 Dec 01; 80(11):2765-73. PMID: 1333301.
      Citations: 16     Fields:    Translation:HumansCells
    507. Orr RK, Hoehn JL, Col NF, Chao R, Khan W, Hannun YA. Retinoblastoma protein dephosphorylation induced by D-erythro-sphingosine. J Biol Chem. 1992 Nov 25; 267(33):23459-62. PMID: 1385423.
      Citations: 14     Fields:    Translation:HumansCells
    508. Obeid LM, Blobe GC, Karolak LA, Hannun YA, Obeid LM, Blobe GC, Karolak LA, Hannun YA. Cloning and characterization of the major promoter of the human protein kinase C beta gene. Regulation by phorbol esters. J Biol Chem. 1992 Oct 15; 267(29):20804-10. PMID: 1400396.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    509. Bielawska A, Linardic CM, Hannun YA, Bielawska A, Linardic CM, Hannun YA. Ceramide-mediated biology. Determination of structural and stereospecific requirements through the use of N-acyl-phenylaminoalcohol analogs. J Biol Chem. 1992 Sep 15; 267(26):18493-7. PMID: 1526986.
      Citations: 22     Fields:    Translation:AnimalsCells
    510. Bielawska A, Linardic CM, Hannun YA, Bielawska A, Linardic CM, Hannun YA. Modulation of cell growth and differentiation by ceramide. FEBS Lett. 1992 Jul 28; 307(2):211-4. PMID: 1644175.
      Citations: 19     Fields:    Translation:HumansCells
    511. Linardic CM, Jayadev S, Hannun YA, Linardic CM, Jayadev S, Hannun YA. Brefeldin A promotes hydrolysis of sphingomyelin. J Biol Chem. 1992 Jul 25; 267(21):14909-11. PMID: 1634530.
      Citations: 4     Fields:    Translation:Cells
    512. Khan WA, Alessenko AV, Sahyoun N, Hannun YA, Khan WA, Alessenko AV, Sahyoun N, Hannun YA. Sphingosine activation of protein kinases in Jurkat T cells. In vitro phosphorylation of endogenous protein substrates and specificity of action. J Biol Chem. 1992 Jul 25; 267(21):15246-51. PMID: 1634554.
      Citations: 10     Fields:    Translation:Cells
    513. Wetsel WC, Khan WA, Merchenthaler I, Rivera H, Halpern AE, Phung HM, Negro-Vilar A, Hannun YA, Wetsel WC, Khan WA, Merchenthaler I, Rivera H, Halpern AE, Phung HM, Negro-Vilar A, Hannun YA. Tissue and cellular distribution of the extended family of protein kinase C isoenzymes. J Cell Biol. 1992 Apr; 117(1):121-33. PMID: 1556149; PMCID: PMC2289401.
      Citations: 85     Fields:    Translation:AnimalsCells
    514. Dobrowsky RT, Hannun YA, Dobrowsky RT, Hannun YA. Ceramide stimulates a cytosolic protein phosphatase. J Biol Chem. 1992 Mar 15; 267(8):5048-51. PMID: 1312082.
      Citations: 73     Fields:    Translation:HumansCells
    515. Orr RK, Hoehn JL, Col NF, Werner MH, Bielawska AE, Hannun YA. Multiphasic generation of diacylglycerol in thrombin-activated human platelets. Biochem J. 1992 Mar 15; 282 ( Pt 3):815-20. PMID: 1554365; PMCID: PMC1130860.
      Citations: 3     Fields:    Translation:HumansCells
    516. Khan WA, Blobe GC, Hannun YA, Khan WA, Blobe GC, Hannun YA. Activation of protein kinase C by oleic acid. Determination and analysis of inhibition by detergent micelles and physiologic membranes: requirement for free oleate. J Biol Chem. 1992 Feb 25; 267(6):3605-12. PMID: 1740412.
      Citations: 16     Fields:    Translation:HumansCells
    517. Alessenko A, Khan WA, Wetsel WC, Hannun YA, Alessenko A, Khan WA, Wetsel WC, Hannun YA. Selective changes in protein kinase C isoenzymes in rat liver nuclei during liver regeneration. Biochem Biophys Res Commun. 1992 Feb 14; 182(3):1333-9. PMID: 1540177.
      Citations: 4     Fields:    Translation:AnimalsCells
    518. Werner MH, Bielawska AE, Hannun YA, Werner MH, Bielawska AE, Hannun YA. Quantitative analysis of diacylglycerol second messengers in human platelets: correlation with aggregation and secretion. Mol Pharmacol. 1992 Feb; 41(2):382-6. PMID: 1538714.
      Citations: 4     Fields:    Translation:HumansCells
    519. Bell R, Burns D, Okazaki T, Hannun Y, Bell R, Burns D, Okazaki T, Hannun Y. Network of signal transduction pathways involving lipids: protein kinase C-dependent and -independent pathways. Adv Exp Med Biol. 1992; 318:275-84. PMID: 1636498.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    520. McDonald OB, Hannun YA, Reynolds CH, Sahyoun N, McDonald OB, Hannun YA, Reynolds CH, Sahyoun N. Activation of casein kinase II by sphingosine. J Biol Chem. 1991 Nov 15; 266(32):21773-6. PMID: 1939200.
      Citations: 15     Fields:    Translation:AnimalsCells
    521. Khan W, el Touny S, Hannun YA, Khan W, el Touny S, Hannun YA. Arachidonic and cis-unsaturated fatty acids induce selective platelet substrate phosphorylation through activation of cytosolic protein kinase C. FEBS Lett. 1991 Nov 04; 292(1-2):98-102. PMID: 1959637.
      Citations: 5     Fields:    Translation:HumansCells
    522. Khan WA, Mascarella SW, Lewin AH, Wyrick CD, Carroll FI, Hannun YA, Khan WA, Mascarella SW, Lewin AH, Wyrick CD, Carroll FI, Hannun YA. Use of D-erythro-sphingosine as a pharmacological inhibitor of protein kinase C in human platelets. Biochem J. 1991 Sep 01; 278 ( Pt 2):387-92. PMID: 1898331; PMCID: PMC1151354.
      Citations: 3     Fields:    Translation:HumansCells
    523. Werner MH, Hannun YA, Werner MH, Hannun YA. Delayed accumulation of diacylglycerol in platelets as a mechanism for regulation of onset of aggregation and secretion. Blood. 1991 Jul 15; 78(2):435-44. PMID: 2070079.
      Citations: 2     Fields:    Translation:HumansCells
    524. Werner MH, Senzel L, Bielawska A, Khan W, Hannun YA, Werner MH, Senzel L, Bielawska A, Khan W, Hannun YA. Diacylglycerol overcomes aspirin inhibition of platelets: evidence for a necessary role for diacylglycerol accumulation in platelet activation. Mol Pharmacol. 1991 Apr; 39(4):547-56. PMID: 2017154.
      Citations: 5     Fields:    Translation:HumansCells
    525. Dennis EA, Rhee SG, Billah MM, Hannun YA, Dennis EA, Rhee SG, Billah MM, Hannun YA. Role of phospholipase in generating lipid second messengers in signal transduction. FASEB J. 1991 Apr; 5(7):2068-77. PMID: 1901288.
      Citations: 115     Fields:    Translation:Cells
    526. Kim MY, Linardic C, Obeid L, Hannun Y, Kim MY, Linardic C, Obeid L, Hannun Y. Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiation. J Biol Chem. 1991 Jan 05; 266(1):484-9. PMID: 1845977.
      Citations: 125     Fields:    Translation:HumansCells
    527. Hannun YA, Merrill AH, Bell RM, Hannun YA, Merrill AH, Bell RM. Use of sphingosine as inhibitor of protein kinase C. Methods Enzymol. 1991; 201:316-28. PMID: 1943771.
      Citations: 8     Fields:    Translation:AnimalsCells
    528. Khan WA, Dobrowsky R, el Touny S, Hannun YA, Khan WA, Dobrowsky R, el Touny S, Hannun YA. Protein kinase C and platelet inhibition by D-erythro-sphingosine: comparison with N,N-dimethylsphingosine and commercial preparation. Biochem Biophys Res Commun. 1990 Oct 30; 172(2):683-91. PMID: 2241961.
      Citations: 10     Fields:    Translation:HumansCells
    529. el Touny S, Khan W, Hannun Y, el Touny S, Khan W, Hannun Y. Regulation of platelet protein kinase C by oleic acid. Kinetic analysis of allosteric regulation and effects on autophosphorylation, phorbol ester binding, and susceptibility to inhibition. J Biol Chem. 1990 Sep 25; 265(27):16437-43. PMID: 2118907.
      Citations: 20     Fields:    Translation:HumansCells
    530. Okazaki T, Bielawska A, Bell RM, Hannun YA, Okazaki T, Bielawska A, Bell RM, Hannun YA. Role of ceramide as a lipid mediator of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation. J Biol Chem. 1990 Sep 15; 265(26):15823-31. PMID: 2394750.
      Citations: 87     Fields:    Translation:HumansCells
    531. Hannun YA, Bell RM, Hannun YA, Bell RM. Rat brain protein kinase C. Kinetic analysis of substrate dependence, allosteric regulation, and autophosphorylation. J Biol Chem. 1990 Feb 15; 265(5):2962-72. PMID: 2303435.
      Citations: 10     Fields:    Translation:AnimalsCells
    532. Obeid LM, Okazaki T, Karolak LA, Hannun YA, Obeid LM, Okazaki T, Karolak LA, Hannun YA. Transcriptional regulation of protein kinase C by 1,25-dihydroxyvitamin D3 in HL-60 cells. J Biol Chem. 1990 Feb 05; 265(4):2370-4. PMID: 2298754.
      Citations: 11     Fields:    Translation:HumansCells
    533. Hannun YA, Bell RM, Hannun YA, Bell RM. Regulation of protein kinase C by sphingosine and lysosphingolipids. Clin Chim Acta. 1989 Dec 15; 185(3):333-45. PMID: 2695275.
      Citations: 23     Fields:    Translation:Cells
    534. Sane DC, Bielawska A, Greenberg CS, Hannun YA, Sane DC, Bielawska A, Greenberg CS, Hannun YA. Cyclic GMP analogs inhibit gamma thrombin-induced arachidonic acid release in human platelets. Biochem Biophys Res Commun. 1989 Dec 15; 165(2):708-14. PMID: 2557018.
      Citations: 4     Fields:    Translation:HumansCells
    535. Okazaki T, Bell RM, Hannun YA, Okazaki T, Bell RM, Hannun YA. Sphingomyelin turnover induced by vitamin D3 in HL-60 cells. Role in cell differentiation. J Biol Chem. 1989 Nov 15; 264(32):19076-80. PMID: 2808413.
      Citations: 126     Fields:    Translation:HumansCells
    536. Conkling PR, Patton KL, Hannun YA, Greenberg CS, Weinberg JB, Conkling PR, Patton KL, Hannun YA, Greenberg CS, Weinberg JB. Sphingosine inhibits monocyte tissue factor-initiated coagulation by altering factor VII binding. J Biol Chem. 1989 Nov 05; 264(31):18440-4. PMID: 2808383.
      Citations: 11     Fields:    Translation:HumansCells
    537. Hannun YA, Foglesong RJ, Bell RM, Hannun YA, Foglesong RJ, Bell RM. The adriamycin-iron(III) complex is a potent inhibitor of protein kinase C. J Biol Chem. 1989 Jun 15; 264(17):9960-6. PMID: 2542337.
      Citations: 7     Fields:    Translation:AnimalsCells
    538. Merrill AH, Nimkar S, Menaldino D, Hannun YA, Loomis C, Bell RM, Tyagi SR, Lambeth JD, Stevens VL, Hunter R, Merrill AH, Nimkar S, Menaldino D, Hannun YA, Loomis C, Bell RM, Tyagi SR, Lambeth JD, Stevens VL, Hunter R, et al. Structural requirements for long-chain (sphingoid) base inhibition of protein kinase C in vitro and for the cellular effects of these compounds. Biochemistry. 1989 Apr 18; 28(8):3138-45. PMID: 2742830.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    539. Hannun YA, Bell RM, Hannun YA, Bell RM. Functions of sphingolipids and sphingolipid breakdown products in cellular regulation. Science. 1989 Jan 27; 243(4890):500-7. PMID: 2643164.
      Citations: 200     Fields:    Translation:HumansAnimals
    540. Hannun YA, Bell RM, Hannun YA, Bell RM. Aminoacridines, potent inhibitors of protein kinase C. J Biol Chem. 1988 Apr 15; 263(11):5124-31. PMID: 3258596.
      Citations: 18     Fields:    Translation:Animals
    541. Faucher M, Gironès N, Hannun YA, Bell RM, Davis RJ, Faucher M, Giron?s N, Hannun YA, Bell RM, Davis RJ. Regulation of the epidermal growth factor receptor phosphorylation state by sphingosine in A431 human epidermoid carcinoma cells. J Biol Chem. 1988 Apr 15; 263(11):5319-27. PMID: 3162730.
      Citations: 19     Fields:    Translation:HumansCells
    542. Bell RM, Loomis CR, Hannun YA, Bell RM, Loomis CR, Hannun YA. Protein kinase C regulation by sphingosine/lysosphingolipids. Cold Spring Harb Symp Quant Biol. 1988; 53 Pt 1:103-10. PMID: 3076075.
      Citations: 2     Fields:    Translation:AnimalsCells
    543. Hannun YA, Greenberg CS, Bell RM, Hannun YA, Greenberg CS, Bell RM. Sphingosine inhibition of agonist-dependent secretion and activation of human platelets implies that protein kinase C is a necessary and common event of the signal transduction pathways. J Biol Chem. 1987 Oct 05; 262(28):13620-6. PMID: 3115982.
      Citations: 26     Fields:    Translation:HumansCells
    544. Hannun YA, Bell RM, Hannun YA, Bell RM. Lysosphingolipids inhibit protein kinase C: implications for the sphingolipidoses. Science. 1987 Feb 06; 235(4789):670-4. PMID: 3101176.
      Citations: 124     Fields:    Translation:HumansCells
    545. Hannun YA, Bell RM, Hannun YA, Bell RM. Mechanism of activation of protein kinase C: role of diacylglycerol and calcium second messengers. Soc Gen Physiol Ser. 1987; 42:229-40. PMID: 3333191.
      Citations:    Fields:    Translation:HumansAnimalsCells
    546. Hannun YA, Bell RM, Hannun YA, Bell RM. Mixed micellar assay for phorbol ester binding. Methods Enzymol. 1987; 141:287-93. PMID: 3298964.
      Citations: 1     Fields:    Translation:Cells
    547. Merrill AH, Sereni AM, Stevens VL, Hannun YA, Bell RM, Kinkade JM, Merrill AH, Sereni AM, Stevens VL, Hannun YA, Bell RM, Kinkade JM. Inhibition of phorbol ester-dependent differentiation of human promyelocytic leukemic (HL-60) cells by sphinganine and other long-chain bases. J Biol Chem. 1986 Sep 25; 261(27):12610-5. PMID: 3462189.
      Citations: 46     Fields:    Translation:HumansCells
    548. Hannun YA, Loomis CR, Merrill AH, Bell RM, Hannun YA, Loomis CR, Merrill AH, Bell RM. Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets. J Biol Chem. 1986 Sep 25; 261(27):12604-9. PMID: 3462188.
      Citations: 183     Fields:    Translation:HumansCells
    549. Hannun YA, Bell RM, Hannun YA, Bell RM. Phorbol ester binding and activation of protein kinase C on triton X-100 mixed micelles containing phosphatidylserine. J Biol Chem. 1986 Jul 15; 261(20):9341-7. PMID: 3459728.
      Citations: 21     Fields:    Translation:AnimalsCells
    550. Hannun YA, Loomis CR, Bell RM, Hannun YA, Loomis CR, Bell RM. Protein kinase C activation in mixed micelles. Mechanistic implications of phospholipid, diacylglycerol, and calcium interdependencies. J Biol Chem. 1986 Jun 05; 261(16):7184-90. PMID: 3711083.
      Citations: 34     Fields:    Translation:AnimalsCells
    551. Ganong BR, Loomis CR, Hannun YA, Bell RM, Ganong BR, Loomis CR, Hannun YA, Bell RM. Specificity and mechanism of protein kinase C activation by sn-1,2-diacylglycerols. Proc Natl Acad Sci U S A. 1986 Mar; 83(5):1184-8. PMID: 3456578; PMCID: PMC323039.
      Citations: 48     Fields:    Translation:AnimalsCells
    552. Bell RM, Hannun YA, Loomis CR, Bell RM, Hannun YA, Loomis CR. Mechanism of regulation of protein kinase C by lipid second messengers. Symp Fundam Cancer Res. 1986; 39:145-56. PMID: 3321305.
      Citations: 5     Translation:AnimalsCells
    553. Bell RM, Hannun Y, Loomis C, Bell RM, Hannun Y, Loomis C. Mixed micelle assay of protein kinase C. Methods Enzymol. 1986; 124:353-9. PMID: 3520216.
      Citations: 12     Fields:    Translation:Animals
    554. Hannun YA, Loomis CR, Bell RM, Hannun YA, Loomis CR, Bell RM. Activation of protein kinase C by Triton X-100 mixed micelles containing diacylglycerol and phosphatidylserine. J Biol Chem. 1985 Aug 25; 260(18):10039-43. PMID: 3160705.
      Citations: 77     Fields:    Translation:Animals
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