"Holoenzymes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Catalytically active enzymes that are formed by the combination of an apoenzyme (APOENZYMES) and its appropriate cofactors and prosthetic groups.
| Descriptor ID |
D020035
|
| MeSH Number(s) |
D08.811.255
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Holoenzymes".
Below are MeSH descriptors whose meaning is more specific than "Holoenzymes".
This graph shows the total number of publications written about "Holoenzymes" by people in this website by year, and whether "Holoenzymes" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Holoenzymes" by people in Profiles.
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Two PKA RIa holoenzyme states define ATP as an isoform-specific orthosteric inhibitor that competes with the allosteric activator, cAMP. Proc Natl Acad Sci U S A. 2019 08 13; 116(33):16347-16356.
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Single Turnover Autophosphorylation Cycle of the PKA RII? Holoenzyme. PLoS Biol. 2015 Jul; 13(7):e1002192.
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Evaluation of the role of the vaccinia virus uracil DNA glycosylase and A20 proteins as intrinsic components of the DNA polymerase holoenzyme. J Biol Chem. 2011 Jul 15; 286(28):24702-13.
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An extended structure of the APOBEC3G catalytic domain suggests a unique holoenzyme model. J Mol Biol. 2009 Jun 26; 389(5):819-32.
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The structural requirements for ceramide activation of serine-threonine protein phosphatases. J Lipid Res. 2004 Mar; 45(3):496-506.