Interleukin-4

"Interleukin-4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A soluble factor produced by activated T-LYMPHOCYTES that induces the expression of MHC CLASS II GENES and FC RECEPTORS on B-LYMPHOCYTES and causes their proliferation and differentiation. It also acts on T-lymphocytes, MAST CELLS, and several other hematopoietic lineage cells.

Descriptor ID	D015847
MeSH Number(s)	D12.644.276.374.465.186 D12.776.467.374.465.178 D23.529.374.465.186
Concept/Terms	Interleukin-4 Interleukin-4 Interleukin 4 B-Cell Growth Factor-1 B Cell Growth Factor 1 B-Cell Growth Factor-I B Cell Growth Factor I B-Cell Proliferating Factor B Cell Proliferating Factor B-Cell Stimulating Factor-1 B Cell Stimulating Factor 1 B-Cell Stimulatory Factor 1 B-Cell Stimulatory Factor-1 BCGF-1 Binetrakin BSF-1 IL-4 IL4 Mast Cell Growth Factor-2 Mast Cell Growth Factor 2 MCGF-2 B Cell Stimulatory Factor-1 B Cell Stimulatory Factor 1

Below are MeSH descriptors whose meaning is more general than "Interleukin-4".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
Cytokines [D12.644.276.374]
Interleukins [D12.644.276.374.465]
Interleukin-4 [D12.644.276.374.465.186]
Proteins [D12.776]
Intercellular Signaling Peptides and Proteins [D12.776.467]
Cytokines [D12.776.467.374]
Interleukins [D12.776.467.374.465]
Interleukin-4 [D12.776.467.374.465.178]
Biological Factors [D23]
Intercellular Signaling Peptides and Proteins [D23.529]
Cytokines [D23.529.374]
Interleukins [D23.529.374.465]
Interleukin-4 [D23.529.374.465.186]

Below are MeSH descriptors whose meaning is related to "Interleukin-4".

Below are MeSH descriptors whose meaning is more specific than "Interleukin-4".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Interleukin-4" by people in this website by year, and whether "Interleukin-4" was a major or minor topic of these publications.

Bar chart showing 44 publications over 22 distinct years, with a maximum of 4 publications in 2005 and 2006

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1993	1	1	2
1994	0	2	2
1995	1	0	1
1996	1	0	1
1997	1	0	1
1998	1	1	2
2001	1	0	1
2002	1	1	2
2003	2	1	3
2004	1	1	2
2005	2	2	4
2006	2	2	4
2007	0	2	2
2009	1	1	2
2010	1	1	2
2013	0	3	3
2014	2	1	3
2015	1	0	1
2016	0	2	2
2018	0	2	2
2020	1	0	1
2022	0	1	1

Below are the most recent publications written about "Interleukin-4" by people in Profiles.

Shah A, Storek J, Woolson R, Pinckney A, Keyes-Elstein L, Wallace PK, Sempowski GD, McSweeney P, Mayes MD, Crofford L, Csuka ME, Phillips K, Khanna D, Simms R, Ballen K, LeClercq S, Clair WS, Nixon AB, Nash R, Wener M, Brasington R, Silver R, Griffith LM, Furst DE, Goldmuntz E, Sullivan KM. Lymphocyte subset abnormalities in early severe scleroderma favor a Th2 phenotype and are not altered by prior immunosuppressive therapy. Rheumatology (Oxford). 2022 10 06; 61(10):4155-4162.

View in: PubMed
Daseke MJ, Tenkorang-Impraim MAA, Ma Y, Chalise U, Konfrst SR, Garrett MR, DeLeon-Pennell KY, Lindsey ML. Exogenous IL-4 shuts off pro-inflammation in neutrophils while stimulating anti-inflammation in macrophages to induce neutrophil phagocytosis following myocardial infarction. J Mol Cell Cardiol. 2020 08; 145:112-121.

View in: PubMed
Iftikhar IH, Schimmel M, Bender W, Swenson C, Amrol D. Iftikhar and Colleagues Reply: Methodology Clarified. Lung. 2019 02; 197(1):107-109.

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Iftikhar IH, Schimmel M, Bender W, Swenson C, Amrol D. Comparative Efficacy of Anti IL-4, IL-5 and IL-13 Drugs for Treatment of Eosinophilic Asthma: A Network Meta-analysis. Lung. 2018 10; 196(5):517-530.

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Iwanowycz S, Wang J, Altomare D, Hui Y, Fan D. Emodin Bidirectionally Modulates Macrophage Polarization and Epigenetically Regulates Macrophage Memory. J Biol Chem. 2016 May 27; 291(22):11491-503.

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Ma Y, Yabluchanskiy A, Iyer RP, Cannon PL, Flynn ER, Jung M, Henry J, Cates CA, Deleon-Pennell KY, Lindsey ML. Temporal neutrophil polarization following myocardial infarction. Cardiovasc Res. 2016 May 01; 110(1):51-61.

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Taylor RL, Cruickshank MN, Karimi M, Ng HL, Quail E, Kaufman KM, Harley JB, Abraham LJ, Tsao BP, Boackle SA, Ulgiati D. Focused transcription from the human CR2/CD21 core promoter is regulated by synergistic activity of TATA and Initiator elements in mature B cells. Cell Mol Immunol. 2016 Jan; 13(1):119-31.

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Shamran HA, Hamza SJ, Yaseen NY, Al-Juboory AA, Taub DD, Price RL, Nagarkatti M, Nagarkatti PS, Singh UP. Impact of single nucleotide polymorphism in IL-4, IL-4R genes and systemic concentration of IL-4 on the incidence of glioma in Iraqi patients. Int J Med Sci. 2014; 11(11):1147-53.

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Zhou J, Nagarkatti P, Zhong Y, Ginsberg JP, Singh NP, Zhang J, Nagarkatti M. Dysregulation in microRNA expression is associated with alterations in immune functions in combat veterans with post-traumatic stress disorder. PLoS One. 2014; 9(4):e94075.

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Li R, Xie C, Zhang Y, Li B, Donelan W, Li S, Han S, Wang X, Cui T, Tang D. Expression of recombinant human IL-4 in Pichia pastoris and relationship between its glycosylation and biological activity. Protein Expr Purif. 2014 Apr; 96:1-7.

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