Epidermal Growth Factor

"Epidermal Growth Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A 6-kDa polypeptide growth factor initially discovered in mouse submaxillary glands. Human epidermal growth factor was originally isolated from urine based on its ability to inhibit gastric secretion and called urogastrone. Epidermal growth factor exerts a wide variety of biological effects including the promotion of proliferation and differentiation of mesenchymal and EPITHELIAL CELLS. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form.

Descriptor ID	D004815
MeSH Number(s)	D06.472.317.350 D12.644.276.382.500 D12.776.467.382.500 D23.529.382.500
Concept/Terms	Epidermal Growth Factor Epidermal Growth Factor Growth Factor, Epidermal Urogastrone Epidermal Growth Factor-Urogastrone Growth Factor-Urogastrone, Epidermal Human Urinary Gastric Inhibitor beta-Urogastrone beta Urogastrone EGF

Below are MeSH descriptors whose meaning is more general than "Epidermal Growth Factor".

Chemicals and Drugs [D]
Hormones, Hormone Substitutes, and Hormone Antagonists [D06]
Hormones [D06.472]
Gastrointestinal Hormones [D06.472.317]
Epidermal Growth Factor [D06.472.317.350]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
EGF Family of Proteins [D12.644.276.382]
Epidermal Growth Factor [D12.644.276.382.500]
Proteins [D12.776]
Intercellular Signaling Peptides and Proteins [D12.776.467]
EGF Family of Proteins [D12.776.467.382]
Epidermal Growth Factor [D12.776.467.382.500]
Biological Factors [D23]
Intercellular Signaling Peptides and Proteins [D23.529]
EGF Family of Proteins [D23.529.382]
Epidermal Growth Factor [D23.529.382.500]

Below are MeSH descriptors whose meaning is related to "Epidermal Growth Factor".

Below are MeSH descriptors whose meaning is more specific than "Epidermal Growth Factor".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Epidermal Growth Factor" by people in this website by year, and whether "Epidermal Growth Factor" was a major or minor topic of these publications.

Bar chart showing 71 publications over 22 distinct years, with a maximum of 6 publications in 2000 and 2005 and 2013

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	0	1	1
1995	2	2	4
1996	2	2	4
1997	3	0	3
2000	1	5	6
2001	3	1	4
2002	1	3	4
2003	1	1	2
2004	2	2	4
2005	3	3	6
2006	2	2	4
2007	1	4	5
2008	1	1	2
2009	3	0	3
2010	1	2	3
2012	3	0	3
2013	5	1	6
2014	1	0	1
2015	1	1	2
2016	1	0	1
2017	0	2	2
2019	0	1	1

Below are the most recent publications written about "Epidermal Growth Factor" by people in Profiles.

Friedman Ohana R, Hurst R, Rosenblatt M, Levin S, Machleidt T, Kirkland TA, Encell LP, Robers MB, Wood KV. Utilizing a Simple Method for Stoichiometric Protein Labeling to Quantify Antibody Blockade. Sci Rep. 2019 05 07; 9(1):7046.

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Wills MKB, Lau HR, Jones N. The ShcD phosphotyrosine adaptor subverts canonical EGF receptor trafficking. J Cell Sci. 2017 Sep 01; 130(17):2808-2820.

View in: PubMed
Jiang YL, Zhu Y, Moore AB, Miller K, Broome AM. Biotinylated Bioluminescent Probe for Long Lasting Targeted in Vivo Imaging of Xenografted Brain Tumors in Mice. ACS Chem Neurosci. 2018 01 17; 9(1):100-106.

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Barnes RM, Harris IS, Jaehnig EJ, Sauls K, Sinha T, Rojas A, Schachterle W, McCulley DJ, Norris RA, Black BL. MEF2C regulates outflow tract alignment and transcriptional control of Tdgf1. Development. 2016 Mar 01; 143(5):774-9.

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Adada MM, Canals D, Jeong N, Kelkar AD, Hernandez-Corbacho M, Pulkoski-Gross MJ, Donaldson JC, Hannun YA, Obeid LM. Intracellular sphingosine kinase 2-derived sphingosine-1-phosphate mediates epidermal growth factor-induced ezrin-radixin-moesin phosphorylation and cancer cell invasion. FASEB J. 2015 Nov; 29(11):4654-69.

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Broome AM, Ramamurthy G, Lavik K, Liggett A, Kinstlinger I, Basilion J. Optical imaging of targeted ß-galactosidase in brain tumors to detect EGFR levels. Bioconjug Chem. 2015 Apr 15; 26(4):660-8.

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Coaxum SD, Blanton MG, Joyner A, Akter T, Bell PD, Luttrell LM, Raymond JR, Lee MH, Blichmann PA, Garnovskaya MN, Saigusa T. Epidermal growth factor-induced proliferation of collecting duct cells from Oak Ridge polycystic kidney mice involves activation of Na+/H+ exchanger. Am J Physiol Cell Physiol. 2014 Sep 15; 307(6):C554-60.

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Okur MN, Russo A, O'Bryan JP. Receptor tyrosine kinase ubiquitylation involves the dynamic regulation of Cbl-Spry2 by intersectin 1 and the Shp2 tyrosine phosphatase. Mol Cell Biol. 2014 Jan; 34(2):271-9.

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Zhang ZR, Chu WF, Song B, Gooz M, Zhang JN, Yu CJ, Jiang S, Baldys A, Gooz P, Steele S, Owsianik G, Nilius B, Komlosi P, Bell PD. TRPP2 and TRPV4 form an EGF-activated calcium permeable channel at the apical membrane of renal collecting duct cells. PLoS One. 2013; 8(8):e73424.

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Hudson AG, Parrott BB, Qian Y, Schulz C. A temporal signature of epidermal growth factor signaling regulates the differentiation of germline cells in testes of Drosophila melanogaster. PLoS One. 2013; 8(8):e70678.

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