"Strychnine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An alkaloid found in the seeds of STRYCHNOS NUX-VOMICA. It is a competitive antagonist at glycine receptors and thus a convulsant. It has been used as an analeptic, in the treatment of nonketotic hyperglycinemia and sleep apnea, and as a rat poison.
| Descriptor ID |
D013331
|
| MeSH Number(s) |
D03.132.436.681.722 D03.633.100.473.402.681.722
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Strychnine".
Below are MeSH descriptors whose meaning is more specific than "Strychnine".
This graph shows the total number of publications written about "Strychnine" by people in this website by year, and whether "Strychnine" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 1 | 1 | 2 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Strychnine" by people in Profiles.
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The ethanol inhibition of basolateral amygdala neuron spiking is mediated by a ?-aminobutyric acid type A-mediated tonic current. Alcohol Clin Exp Res. 2022 Sep; 46(9):1665-1676.
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Ethanol reduces neuronal excitability of lateral orbitofrontal cortex neurons via a glycine receptor dependent mechanism. Neuropsychopharmacology. 2013 Jun; 38(7):1176-88.
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Effects of the beta-amino acid antagonist TAG on thalamocortical inhibition. Neuropharmacology. 2009 Jun; 56(8):1097-105.
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Pharmacological characterization of glycine-activated currents in HEK 293 cells expressing N-methyl-D-aspartate NR1 and NR3 subunits. J Pharmacol Exp Ther. 2007 Aug; 322(2):739-48.
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Glycine-gated chloride channels depress synaptic transmission in rat hippocampus. J Neurophysiol. 2006 Apr; 95(4):2366-79.
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Chronic ethanol induces synaptic but not extrasynaptic targeting of NMDA receptors. J Neurosci. 2004 Sep 08; 24(36):7859-68.
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Strychnine-sensitive glycine receptors depress hyperexcitability in rat dentate gyrus. J Neurophysiol. 2003 Mar; 89(3):1339-42.
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Pharmacological characterization of glycine-gated chloride currents recorded in rat hippocampal slices. J Neurophysiol. 2002 Mar; 87(3):1515-25.
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Dose and time response analysis of apomorphine's effect on prepulse inhibition of acoustic startle. Behav Brain Res. 1991 Jan 31; 42(1):43-8.
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Studies on the contribution of active metabolites to the anticonvulsant effects of propranolol. Eur J Pharmacol. 1977 Mar 07; 42(1):39-46.