TNF-Related Apoptosis-Inducing Ligand

"TNF-Related Apoptosis-Inducing Ligand" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A transmembrane-protein belonging to the TNF family of intercellular signaling proteins. It is a widely expressed ligand that activates APOPTOSIS by binding to TNF-RELATED APOPTOSIS-INDUCING LIGAND RECEPTORS. The membrane-bound form of the protein can be cleaved by specific CYSTEINE ENDOPEPTIDASES to form a soluble ligand form.

Descriptor ID	D053221
MeSH Number(s)	D12.644.276.374.750.625 D12.776.467.374.750.625 D23.529.374.750.625
Concept/Terms	TNF-Related Apoptosis-Inducing Ligand TNF-Related Apoptosis-Inducing Ligand Apoptosis-Inducing Ligand, TNF-Related TNF Related Apoptosis Inducing Ligand Apo-2 Ligand Apo 2 Ligand Tumor Necrosis Factor Ligand Superfamily Member 10 Apo-2L Protein Apo 2L Protein TNF Superfamily, Member 10 CD253 Antigen Antigen, CD253 TRAIL Protein

Below are MeSH descriptors whose meaning is more general than "TNF-Related Apoptosis-Inducing Ligand".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
Cytokines [D12.644.276.374]
Tumor Necrosis Factors [D12.644.276.374.750]
TNF-Related Apoptosis-Inducing Ligand [D12.644.276.374.750.625]
Proteins [D12.776]
Intercellular Signaling Peptides and Proteins [D12.776.467]
Cytokines [D12.776.467.374]
Tumor Necrosis Factors [D12.776.467.374.750]
TNF-Related Apoptosis-Inducing Ligand [D12.776.467.374.750.625]
Biological Factors [D23]
Intercellular Signaling Peptides and Proteins [D23.529]
Cytokines [D23.529.374]
Tumor Necrosis Factors [D23.529.374.750]
TNF-Related Apoptosis-Inducing Ligand [D23.529.374.750.625]

Below are MeSH descriptors whose meaning is related to "TNF-Related Apoptosis-Inducing Ligand".

Below are MeSH descriptors whose meaning is more specific than "TNF-Related Apoptosis-Inducing Ligand".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "TNF-Related Apoptosis-Inducing Ligand" by people in this website by year, and whether "TNF-Related Apoptosis-Inducing Ligand" was a major or minor topic of these publications.

Bar chart showing 41 publications over 16 distinct years, with a maximum of 7 publications in 2009

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2000	0	1	1
2001	0	1	1
2002	0	2	2
2003	0	3	3
2004	0	2	2
2005	0	4	4
2006	2	4	6
2007	1	1	2
2008	2	0	2
2009	4	3	7
2011	1	1	2
2013	2	0	2
2014	1	0	1
2016	1	2	3
2017	2	0	2
2019	1	0	1

Below are the most recent publications written about "TNF-Related Apoptosis-Inducing Ligand" by people in Profiles.

Ethiraj P, Sambandam Y, Hathaway-Schrader JD, Haque A, Novince CM, Reddy SV. RANKL triggers resistance to TRAIL-induced cell death in oral squamous cell carcinoma. J Cell Physiol. 2020 02; 235(2):1663-1673.

View in: PubMed
Dandachi N, Kelly NJ, Wood JP, Burton CL, Radder JE, Leme AS, Gregory AD, Shapiro SD. Macrophage Elastase Induces TRAIL-mediated Tumor Cell Death through Its Carboxy-Terminal Domain. Am J Respir Crit Care Med. 2017 08 01; 196(3):353-363.

View in: PubMed
Sambandam Y, Reddy SV, Mulligan JL, Voelkel-Johnson C, Wagner CL. Vitamin D Modulation of TRAIL Expression in Human Milk and Mammary Epithelial Cells. Sci Rep. 2017 06 28; 7(1):4362.

View in: PubMed
Sambandam Y, Baird KL, Stroebel M, Kowal E, Balasubramanian S, Reddy SV. Microgravity Induction of TRAIL Expression in Preosteoclast Cells Enhances Osteoclast Differentiation. Sci Rep. 2016 05 04; 6:25143.

View in: PubMed
Fu J, Wu Y, Nguyen H, Heinrichs J, Schutt S, Liu Y, Liu C, Jin J, Anasetti C, Yu XZ. T-bet Promotes Acute Graft-versus-Host Disease by Regulating Recipient Hematopoietic Cells in Mice. J Immunol. 2016 Apr 01; 196(7):3168-79.

View in: PubMed
Walker MM, Novak L, Widener R, Grubbs JA, King J, Hale JY, Ochs MM, Myers LE, Briles DE, Deshane J. PcpA Promotes Higher Levels of Infection and Modulates Recruitment of Myeloid-Derived Suppressor Cells during Pneumococcal Pneumonia. J Immunol. 2016 Mar 01; 196(5):2239-48.

View in: PubMed
Sundaram K, Sambandam Y, Balasubramanian S, Pillai B, Voelkel-Johnson C, Ries WL, Reddy SV. STAT-6 mediates TRAIL induced RANK ligand expression in stromal/preosteoblast cells. Bone. 2015 Feb; 71:137-44.

View in: PubMed
Grandhi TS, Potta T, Taylor DJ, Tian Y, Johnson RH, Meldrum DR, Rege K. Sensitizing cancer cells to TRAIL-induced death by micellar delivery of mitoxantrone. Nanomedicine (Lond). 2014; 9(12):1775-88.

View in: PubMed
Allen JE, Krigsfeld G, Mayes PA, Patel L, Dicker DT, Patel AS, Dolloff NG, Messaris E, Scata KA, Wang W, Zhou JY, Wu GS, El-Deiry WS. Dual inactivation of Akt and ERK by TIC10 signals Foxo3a nuclear translocation, TRAIL gene induction, and potent antitumor effects. Sci Transl Med. 2013 Feb 06; 5(171):171ra17.

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Wang W, Gallant JN, Katz SI, Dolloff NG, Smith CD, Abdulghani J, Allen JE, Dicker DT, Hong B, Navaraj A, El-Deiry WS. Quinacrine sensitizes hepatocellular carcinoma cells to TRAIL and chemotherapeutic agents. Cancer Biol Ther. 2011 Aug 01; 12(3):229-38.

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