"Interleukin-3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A multilineage cell growth factor secreted by LYMPHOCYTES; EPITHELIAL CELLS; and ASTROCYTES which stimulates clonal proliferation and differentiation of various types of blood and tissue cells.
| Descriptor ID |
D007377
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| MeSH Number(s) |
D12.644.276.374.410.240.400 D12.644.276.374.465.032 D12.776.395.240.400 D12.776.467.374.410.240.400 D12.776.467.374.465.032 D23.529.374.410.240.400 D23.529.374.465.169
|
| Concept/Terms |
Interleukin-3- Interleukin-3
- Interleukin 3
- IL-3
- Mast-Cell Colony-Stimulating Factor
- Multipotential Colony-Stimulating Factor
- Multipotential Colony Stimulating Factor
- Erythrocyte Burst-Promoting Factor
- Erythrocyte Burst Promoting Factor
- Burst-Promoting Factor, Erythrocyte
- Burst Promoting Factor, Erythrocyte
- Colony-Stimulating Factor 2 Alpha
- Colony-Stimulating Factor, Mast-Cell
- Colony Stimulating Factor, Mast Cell
- Colony-Stimulating Factor, Multipotential
- Colony Stimulating Factor, Multipotential
- Eosinophil-Mast Cell Growth-Factor
- Eosinophil Mast Cell Growth Factor
- Hematopoietin-2
- Hematopoietin 2
- P-Cell Stimulating Factor
- P Cell Stimulating Factor
|
Below are MeSH descriptors whose meaning is more general than "Interleukin-3".
Below are MeSH descriptors whose meaning is more specific than "Interleukin-3".
This graph shows the total number of publications written about "Interleukin-3" by people in this website by year, and whether "Interleukin-3" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 1 | 2 | 3 |
| 1994 | 1 | 2 | 3 |
| 1995 | 1 | 3 | 4 |
| 1996 | 3 | 5 | 8 |
| 1997 | 1 | 1 | 2 |
| 1998 | 1 | 1 | 2 |
| 1999 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 1 | 1 | 2 |
| 2004 | 3 | 1 | 4 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2018 | 0 | 2 | 2 |
To return to the timeline,
click here.
Below are the most recent publications written about "Interleukin-3" by people in Profiles.
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Barretto KT, Swanson CM, Nguyen CL, Annis DS, Esnault SJ, Mosher DF, Johansson MW. Control of cytokine-driven eosinophil migratory behavior by TGF-beta-induced protein (TGFBI) and periostin. PLoS One. 2018; 13(7):e0201320.
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Caslin HL, Taruselli MT, Paranjape A, Kiwanuka K, Haque T, Chumanevich AP, Oskeritzian CA, Ryan JJ. The Use of Human and Mouse Mast Cell and Basophil Cultures to Assess Type 2 Inflammation. Methods Mol Biol. 2018; 1799:81-92.
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Saurabh K, Scherzer MT, Shah PP, Mims AS, Lockwood WW, Kraft AS, Beverly LJ. The PIM family of oncoproteins: small kinases with huge implications in myeloid leukemogenesis and as therapeutic targets. Oncotarget. 2014 Sep 30; 5(18):8503-14.
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Hall PD, Sinha D, Frankel AE. Fresh frozen plasma and platelet concentrates may increase plasma anti-diphtheria toxin IgG concentrations: Implications for diphtheria fusion protein therapy. Cancer Immunol Immunother. 2006 Aug; 55(8):928-32.
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Qi XJ, Wildey GM, Howe PH. Evidence that Ser87 of BimEL is phosphorylated by Akt and regulates BimEL apoptotic function. J Biol Chem. 2006 Jan 13; 281(2):813-23.
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Cohen KA, Liu TF, Cline JM, Wagner JD, Hall PD, Frankel AE. Safety evaluation of DT388IL3, a diphtheria toxin/interleukin 3 fusion protein, in the cynomolgus monkey. Cancer Immunol Immunother. 2005 Aug; 54(8):799-806.
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Cohen KA, Liu TF, Cline JM, Wagner JD, Hall PD, Frankel AE. Toxicology and pharmacokinetics of DT388IL3, a fusion toxin consisting of a truncated diphtheria toxin (DT388) linked to human interleukin 3 (IL3), in cynomolgus monkeys. Leuk Lymphoma. 2004 Aug; 45(8):1647-56.
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Aho TL, Sandholm J, Peltola KJ, Mankonen HP, Lilly M, Koskinen PJ. Pim-1 kinase promotes inactivation of the pro-apoptotic Bad protein by phosphorylating it on the Ser112 gatekeeper site. FEBS Lett. 2004 Jul 30; 571(1-3):43-9.
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Urieto JO, Liu T, Black JH, Cohen KA, Hall PD, Willingham MC, Pennell LK, Hogge DE, Kreitman RJ, Frankel AE. Expression and purification of the recombinant diphtheria fusion toxin DT388IL3 for phase I clinical trials. Protein Expr Purif. 2004 Jan; 33(1):123-33.
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Yan B, Zemskova M, Holder S, Chin V, Kraft A, Koskinen PJ, Lilly M. The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death. J Biol Chem. 2003 Nov 14; 278(46):45358-67.