"Factor XII" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Stable blood coagulation factor activated by contact with the subendothelial surface of an injured vessel. Along with prekallikrein, it serves as the contact factor that initiates the intrinsic pathway of blood coagulation. Kallikrein activates factor XII to XIIa. Deficiency of factor XII, also called the Hageman trait, leads to increased incidence of thromboembolic disease. Mutations in the gene for factor XII that appear to increase factor XII amidolytic activity are associated with HEREDITARY ANGIOEDEMA TYPE III.
| Descriptor ID |
D005174
|
| MeSH Number(s) |
D12.776.124.125.450 D23.119.450
|
| Concept/Terms |
Factor XII- Factor XII
- Factor Twelve
- Hageman Factor
- Factor 12
- Coagulation Factor XII
|
Below are MeSH descriptors whose meaning is more general than "Factor XII".
Below are MeSH descriptors whose meaning is more specific than "Factor XII".
This graph shows the total number of publications written about "Factor XII" by people in this website by year, and whether "Factor XII" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 0 | 1 |
| 1996 | 2 | 0 | 2 |
| 1997 | 1 | 2 | 3 |
| 1998 | 1 | 0 | 1 |
| 1999 | 2 | 1 | 3 |
| 2001 | 0 | 2 | 2 |
| 2002 | 1 | 2 | 3 |
| 2003 | 1 | 1 | 2 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 1 | 0 | 1 |
| 2010 | 0 | 2 | 2 |
| 2013 | 1 | 1 | 2 |
| 2014 | 0 | 3 | 3 |
| 2015 | 0 | 1 | 1 |
| 2016 | 0 | 2 | 2 |
| 2019 | 0 | 1 | 1 |
| 2020 | 0 | 2 | 2 |
| 2021 | 2 | 1 | 3 |
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Below are the most recent publications written about "Factor XII" by people in Profiles.
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Identification of Human Kinin-Forming Enzyme Inhibitors from Medicinal Herbs. Molecules. 2021 Jul 07; 26(14).
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Analysis of cold activation of the contact system in hereditary angioedema with normal C1 inhibitor. Mol Immunol. 2021 08; 136:150-160.
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Blood Clotting and the Pathogenesis of Types I and II Hereditary Angioedema. Clin Rev Allergy Immunol. 2021 Jun; 60(3):348-356.
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Protease activity in single-chain prekallikrein. Blood. 2020 02 20; 135(8):558-567.
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sgp120 and the contact system in hereditary angioedema: A diagnostic tool in HAE with normal C1 inhibitor. Mol Immunol. 2020 03; 119:27-34.
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Nomenclature of factor XI and the contact system. J Thromb Haemost. 2019 12; 17(12):2216-2219.
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Cytokine and estrogen stimulation of endothelial cells augments activation of the prekallikrein-high molecular weight kininogen complex: Implications for hereditary angioedema. J Allergy Clin Immunol. 2017 Jul; 140(1):170-176.
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Complement, Kinins, and Hereditary Angioedema: Mechanisms of Plasma Instability when C1 Inhibitor is Absent. Clin Rev Allergy Immunol. 2016 Oct; 51(2):207-15.
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Deficiency of plasminogen activator inhibitor 2 in plasma of patients with hereditary angioedema with normal C1 inhibitor levels. J Allergy Clin Immunol. 2016 06; 137(6):1822-1829.e1.
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Bradykinin-mediated diseases. Chem Immunol Allergy. 2014; 100:140-7.