"Genes, MDR" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Genes for MEMBRANE TRANSPORT PROTEINS that confer resistance to toxic compounds. Several superfamilies of these multidrug export proteins are known and found in both prokaryotes and eukaryotes.
| Descriptor ID |
D019450
|
| MeSH Number(s) |
G05.360.340.024.340.361 G05.360.340.024.340.645.500
|
| Concept/Terms |
Genes, MDR- Genes, MDR
- Gene, MDR
- MDR Gene
- Multidrug Efflux Pump Genes
- Multidrug Resistance Gene
- Gene, Multidrug Resistance
- Genes, Multidrug Resistance
- Multidrug Resistance Genes
- Resistance Gene, Multidrug
- Resistance Genes, Multidrug
- MDR Genes
|
Below are MeSH descriptors whose meaning is more general than "Genes, MDR".
Below are MeSH descriptors whose meaning is more specific than "Genes, MDR".
This graph shows the total number of publications written about "Genes, MDR" by people in this website by year, and whether "Genes, MDR" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 |
| 1997 | 2 | 1 | 3 |
| 1998 | 0 | 1 | 1 |
| 1999 | 1 | 0 | 1 |
| 2000 | 1 | 0 | 1 |
| 2005 | 1 | 0 | 1 |
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Below are the most recent publications written about "Genes, MDR" by people in Profiles.
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Misra S, Ghatak S, Toole BP. Regulation of MDR1 expression and drug resistance by a positive feedback loop involving hyaluronan, phosphoinositide 3-kinase, and ErbB2. J Biol Chem. 2005 May 27; 280(21):20310-5.
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Ogretmen B, Safa AR. Identification and characterization of the MDR1 promoter-enhancing factor 1 (MEF1) in the multidrug resistant HL60/VCR human acute myeloid leukemia cell line. Biochemistry. 2000 Jan 11; 39(1):194-204.
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Ogretmen B, Safa AR. Negative regulation of MDR1 promoter activity in MCF-7, but not in multidrug resistant MCF-7/Adr, cells by cross-coupled NF-kappa B/p65 and c-Fos transcription factors and their interaction with the CAAT region. Biochemistry. 1999 Feb 16; 38(7):2189-99.
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Komarov PG, Shtil AA, Holian O, Tee L, Buckingham L, Mechetner EB, Roninson IB, Coon JS. Activation of the LRP (lung resistance-related protein) gene by short-term exposure of human leukemia cells to phorbol ester and cytarabine. Oncol Res. 1998; 10(4):185-92.
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Levine EA, Holzmayer T, Bacus S, Mechetner E, Mera R, Bolliger C, Roninson IB, Das Gupta TK. Evaluation of newer prognostic markers for adult soft tissue sarcomas. J Clin Oncol. 1997 Oct; 15(10):3249-57.
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Walter RJ, Shtil AA, Roninson IB, Holian O. 60-Hz electric fields inhibit protein kinase C activity and multidrug resistance gene (MDR1) up-regulation. Radiat Res. 1997 Mar; 147(3):369-75.
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Re GG, Willingham MC, el Bahtimi R, Brownlee NA, Hazen-Martin DJ, Garvin AJ. Anaplasia and drug selection-independent overexpression of the multidrug resistance gene, MDR1, in Wilms' tumor. Mod Pathol. 1997 Feb; 10(2):129-36.
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Komarov PG, Shtil AA, Buckingham LE, Balasubramanian M, Piraner O, Emanuele RM, Roninson IB, Coon JS. Inhibition of cytarabine-induced MDR1 (P-glycoprotein) gene activation in human tumor cells by fatty acid-polyethylene glycol-fatty acid diesters, novel inhibitors of P-glycoprotein function. Int J Cancer. 1996 Oct 09; 68(2):245-50.