Sphingosine N-Acyltransferase
"Sphingosine N-Acyltransferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the acyltransferase of SPHINGOSINE to N-acylsphingosine using acyl-COENZYME A as donor and COENZYME A as acceptor. The enzyme is mainly localized in the MITOCHONDRIA.
| Descriptor ID |
D051049
|
| MeSH Number(s) |
D08.811.913.050.712
|
| Concept/Terms |
Sphingosine N-Acyltransferase- Sphingosine N-Acyltransferase
- N-Acyltransferase, Sphingosine
- Sphingosine N Acyltransferase
- Sphingosine Acyltransferase
- Acyltransferase, Sphingosine
- Ceramide Synthetase
- Synthetase, Ceramide
- Fatty Acyl-CoA - Sphingosine Acyltransferase
- Fatty Acyl CoA Sphingosine Acyltransferase
|
Below are MeSH descriptors whose meaning is more general than "Sphingosine N-Acyltransferase".
Below are MeSH descriptors whose meaning is more specific than "Sphingosine N-Acyltransferase".
This graph shows the total number of publications written about "Sphingosine N-Acyltransferase" by people in this website by year, and whether "Sphingosine N-Acyltransferase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 2 | 2 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 3 | 3 |
| 2010 | 1 | 0 | 1 |
| 2011 | 2 | 1 | 3 |
| 2012 | 3 | 0 | 3 |
| 2013 | 1 | 0 | 1 |
| 2015 | 2 | 0 | 2 |
| 2016 | 1 | 0 | 1 |
| 2017 | 2 | 2 | 4 |
| 2018 | 2 | 0 | 2 |
| 2019 | 1 | 0 | 1 |
| 2021 | 4 | 0 | 4 |
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Below are the most recent publications written about "Sphingosine N-Acyltransferase" by people in Profiles.
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Dependence of ABCB1 transporter expression and function on distinct sphingolipids generated by ceramide synthases-2 and -6 in chemoresistant renal cancer. J Biol Chem. 2022 02; 298(2):101492.
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Ceramide synthase 6 mediates sex-specific metabolic response to dietary folic acid in mice. J Nutr Biochem. 2021 12; 98:108832.
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Ceramide synthase 2-C24:1 -ceramide axis limits the metastatic potential of ovarian cancer cells. FASEB J. 2021 02; 35(2):e21287.
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Targeting sphingosine kinase 1 (SK1) enhances oncogene-induced senescence through ceramide synthase 2 (CerS2)-mediated generation of very-long-chain ceramides. Cell Death Dis. 2021 01 04; 12(1):27.
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Mitochondrial protein import is regulated by p17/PERMIT to mediate lipid metabolism and cellular stress. Sci Adv. 2019 09; 5(9):eaax1978.
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Ceramide Synthase 6 Deficiency Enhances Inflammation in the DSS model of Colitis. Sci Rep. 2018 01 26; 8(1):1627.
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Decreased ceramide underlies mitochondrial dysfunction in Charcot-Marie-Tooth 2F. FASEB J. 2018 03; 32(3):1716-1728.
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Adoptive Transfer of Ceramide Synthase 6 Deficient Splenocytes Reduces the Development of Colitis. Sci Rep. 2017 Nov 14; 7(1):15552.
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TGF-? receptor I/II trafficking and signaling at primary cilia are inhibited by ceramide to attenuate cell migration and tumor metastasis. Sci Signal. 2017 Oct 24; 10(502).
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HPV/E7 induces chemotherapy-mediated tumor suppression by ceramide-dependent mitophagy. EMBO Mol Med. 2017 08; 9(8):1030-1051.