"Connectin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A giant elastic protein of molecular mass ranging from 2,993 kDa (cardiac), 3,300 kDa (psoas), to 3,700 kDa (soleus) having a kinase domain. The amino- terminal is involved in a Z line binding, and the carboxy-terminal region is bound to the myosin filament with an overlap between the counter-connectin filaments at the M line.
| Descriptor ID |
D064211
|
| MeSH Number(s) |
D08.811.913.696.620.682.324 D12.776.210.500.246
|
| Concept/Terms |
Myomesin- Myomesin
- M-Line 185 kDa Protein
- M Line 185 kDa Protein
- M-Protein (muscle)
- Muscle M-Line Protein
- M-Line Protein, Muscle
- Muscle M Line Protein
- Protein, Muscle M-Line
- Skelemins
- M-Band Proteins
- M Band Proteins
- Proteins, M-Band
|
Below are MeSH descriptors whose meaning is more general than "Connectin".
Below are MeSH descriptors whose meaning is more specific than "Connectin".
This graph shows the total number of publications written about "Connectin" by people in this website by year, and whether "Connectin" was a major or minor topic of these publications.
To see the data from this visualization as text,
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 2 | 2 |
| 2002 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Connectin" by people in Profiles.
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Paulus WJ, Zile MR. From Systemic Inflammation to Myocardial Fibrosis: The Heart Failure With Preserved Ejection Fraction Paradigm Revisited. Circ Res. 2021 05 14; 128(10):1451-1467.
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Brown EE, Murray B, Vaishnav J, Tampakakis E, Barouch LA, James C, Murphy AM, Judge DP. Genetic Dilated Cardiomyopathy Due to TTN Variants Without Known Familial Disease. Circ Genom Precis Med. 2020 12; 13(6):e003082.
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Mukherjee R. Frank(ly), Star(t)ling: A structural protein contributes to changes in left ventricular performance with cardiomyopathies? J Thorac Cardiovasc Surg. 2018 07; 156(1):215-216.
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LeWinter MM, Zile MR. Could Modification of Titin Contribute to an Answer for Heart Failure With Preserved Ejection Fraction? Circulation. 2016 10 11; 134(15):1100-1104.
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Zile MR, Baicu CF, Ikonomidis JS, Stroud RE, Nietert PJ, Bradshaw AD, Slater R, Palmer BM, Van Buren P, Meyer M, Redfield MM, Bull DA, Granzier HL, LeWinter MM. Myocardial stiffness in patients with heart failure and a preserved ejection fraction: contributions of collagen and titin. Circulation. 2015 Apr 07; 131(14):1247-59.
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Makarenko I, Opitz CA, Leake MC, Neagoe C, Kulke M, Gwathmey JK, del Monte F, Hajjar RJ, Linke WA. Passive stiffness changes caused by upregulation of compliant titin isoforms in human dilated cardiomyopathy hearts. Circ Res. 2004 Oct 01; 95(7):708-16.
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Neagoe C, Kulke M, del Monte F, Gwathmey JK, de Tombe PP, Hajjar RJ, Linke WA. Titin isoform switch in ischemic human heart disease. Circulation. 2002 Sep 10; 106(11):1333-41.
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Carroll SL, Horowits R. Myofibrillogenesis and formation of cell contacts mediate the localization of N-RAP in cultured chick cardiomyocytes. Cell Motil Cytoskeleton. 2000 Sep; 47(1):63-76.
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Doevendans PA, Kubalak SW, An RH, Becker DK, Chien KR, Kass RS. Differentiation of cardiomyocytes in floating embryoid bodies is comparable to fetal cardiomyocytes. J Mol Cell Cardiol. 2000 May; 32(5):839-51.
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Skeie GO, Pandey JP, Aarli JA, Gilhus NE. TNFA and TNFB polymorphisms in myasthenia gravis. Arch Neurol. 1999 Apr; 56(4):457-61.