Suppressor of Cytokine Signaling 1 Protein
"Suppressor of Cytokine Signaling 1 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A suppressor of cytokine signaling protein that consists of an N-terminal kinase-inhibitory region, a central SH2 DOMAIN, a characteristic C-terminal SOCS box (a 40-amino acid motif, which functions to recruit E3 UBIQUITIN-PROTEIN LIGASE COMPLEXES). SOCS1 functions as a negative regulator of CYTOKINES that signal through the JANUS KINASES-STAT 3 TRANSCRIPTION FACTOR (JAK/STAT3) pathway by inhibiting the activity of JANUS KINASES.
| Descriptor ID |
D000071222
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| MeSH Number(s) |
D12.644.360.024.374.500 D12.776.157.057.249.500 D12.776.476.024.437.500
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Suppressor of Cytokine Signaling 1 Protein".
Below are MeSH descriptors whose meaning is more specific than "Suppressor of Cytokine Signaling 1 Protein".
This graph shows the total number of publications written about "Suppressor of Cytokine Signaling 1 Protein" by people in this website by year, and whether "Suppressor of Cytokine Signaling 1 Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2013 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 0 | 1 | 1 |
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Below are the most recent publications written about "Suppressor of Cytokine Signaling 1 Protein" by people in Profiles.
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IFN-?4 Attenuates Antiviral Responses by Enhancing Negative Regulation of IFN Signaling. J Immunol. 2017 12 01; 199(11):3808-3820.
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IL-10-Induced miR-155 Targets SOCS1 To Enhance IgE-Mediated Mast Cell Function. J Immunol. 2016 06 01; 196(11):4457-67.
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Staphylococcal enterotoxin B-induced microRNA-155 targets SOCS1 to promote acute inflammatory lung injury. Infect Immun. 2014 Jul; 82(7):2971-9.
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SOCS-1/3 participation in FGF-2 signaling to modulate RANK ligand expression in paget's disease of bone. J Cell Biochem. 2013 Sep; 114(9):2032-8.