"beta-Arrestins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Non-visual system arrestins that negatively regulate G-PROTEIN-COUPLED RECEPTORS (GPCRs) and may also function independently of GPCR signaling. They bind and recruit many different signaling factors, including MITOGEN-ACTIVATED PROTEIN KINASES; SRC-FAMILY-KINASES; and FILAMIN to GPCRs and may recognize different phosphorylation states of the receptors to determine the specificity of the cellular response to signaling.
| Descriptor ID |
D000071557
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| MeSH Number(s) |
D12.644.360.024.098.525 D12.776.157.057.005.525 D12.776.476.024.104.525 D12.776.543.090.525
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "beta-Arrestins".
Below are MeSH descriptors whose meaning is more specific than "beta-Arrestins".
This graph shows the total number of publications written about "beta-Arrestins" by people in this website by year, and whether "beta-Arrestins" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 2 | 2 |
| 2000 | 0 | 4 | 4 |
| 2001 | 0 | 5 | 5 |
| 2002 | 0 | 3 | 3 |
| 2003 | 0 | 2 | 2 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 2 | 2 |
| 2006 | 0 | 5 | 5 |
| 2007 | 0 | 3 | 3 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 2 | 2 |
| 2013 | 0 | 6 | 6 |
| 2014 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
| 2021 | 0 | 1 | 1 |
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click here.
Below are the most recent publications written about "beta-Arrestins" by people in Profiles.
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Wu B, Hand W, Alexov E. Opioid Addiction and Opioid Receptor Dimerization: Structural Modeling of the OPRD1 and OPRM1 Heterodimer and Its Signaling Pathways. Int J Mol Sci. 2021 Sep 24; 22(19).
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Ghosh E, Dwivedi H, Baidya M, Srivastava A, Kumari P, Stepniewski T, Kim HR, Lee MH, van Gastel J, Chaturvedi M, Roy D, Pandey S, Maharana J, Guixà-González R, Luttrell LM, Chung KY, Dutta S, Selent J, Shukla AK. Conformational Sensors and Domain Swapping Reveal Structural and Functional Differences between ß-Arrestin Isoforms. Cell Rep. 2019 09 24; 28(13):3287-3299.e6.
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Luttrell LM, Wang J, Plouffe B, Smith JS, Yamani L, Kaur S, Jean-Charles PY, Gauthier C, Lee MH, Pani B, Kim J, Ahn S, Rajagopal S, Reiter E, Bouvier M, Shenoy SK, Laporte SA, Rockman HA, Lefkowitz RJ. Manifold roles of ß-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9. Sci Signal. 2018 09 25; 11(549).
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Peterson YK, Luttrell LM. The Diverse Roles of Arrestin Scaffolds in G Protein-Coupled Receptor Signaling. Pharmacol Rev. 2017 07; 69(3):256-297.
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Lee MH, Appleton KM, Strungs EG, Kwon JY, Morinelli TA, Peterson YK, Laporte SA, Luttrell LM. The conformational signature of ß-arrestin2 predicts its trafficking and signalling functions. Nature. 2016 Mar 31; 531(7596):665-8.
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Kendall RT, Lee MH, Pleasant DL, Robinson K, Kuppuswamy D, McDermott PJ, Luttrell LM. Arrestin-dependent angiotensin AT1 receptor signaling regulates Akt and mTor-mediated protein synthesis. J Biol Chem. 2014 Sep 19; 289(38):26155-26166.
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Fan H. ß-Arrestins 1 and 2 are critical regulators of inflammation. Innate Immun. 2014 Jul; 20(5):451-60.
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Morinelli TA, Lee MH, Kendall RT, Luttrell LM, Walker LP, Ullian ME. Angiotensin II activates NF-?B through AT1A receptor recruitment of ß-arrestin in cultured rat vascular smooth muscle cells. Am J Physiol Cell Physiol. 2013 Jun 15; 304(12):C1176-86.
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Wood SK, Zhang XY, Reyes BA, Lee CS, Van Bockstaele EJ, Valentino RJ. Cellular adaptations of dorsal raphe serotonin neurons associated with the development of active coping in response to social stress. Biol Psychiatry. 2013 Jun 01; 73(11):1087-94.
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Leonard AP, Appleton KM, Luttrell LM, Peterson YK. A high-content, live-cell, and real-time approach to the quantitation of ligand-induced ß-Arrestin2 and Class A/Class B GPCR mobilization. Microsc Microanal. 2013 Feb; 19(1):150-70.