"beta-Arrestins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Non-visual system arrestins that negatively regulate G-PROTEIN-COUPLED RECEPTORS (GPCRs) and may also function independently of GPCR signaling. They bind and recruit many different signaling factors, including MITOGEN-ACTIVATED PROTEIN KINASES; SRC-FAMILY-KINASES; and FILAMIN to GPCRs and may recognize different phosphorylation states of the receptors to determine the specificity of the cellular response to signaling.
| Descriptor ID |
D000071557
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| MeSH Number(s) |
D12.644.360.024.098.525 D12.776.157.057.005.525 D12.776.476.024.104.525 D12.776.543.090.525
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "beta-Arrestins".
Below are MeSH descriptors whose meaning is more specific than "beta-Arrestins".
This graph shows the total number of publications written about "beta-Arrestins" by people in this website by year, and whether "beta-Arrestins" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 3 | 3 |
| 2000 | 0 | 4 | 4 |
| 2001 | 0 | 5 | 5 |
| 2002 | 0 | 3 | 3 |
| 2003 | 0 | 2 | 2 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 2 | 2 |
| 2006 | 0 | 5 | 5 |
| 2007 | 0 | 3 | 3 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 2 | 2 |
| 2013 | 0 | 6 | 6 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
| 2019 | 1 | 1 | 2 |
| 2020 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "beta-Arrestins" by people in Profiles.
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Inhibition of MRGPRX2 but not FceRI or MrgprB2-mediated mast cell degranulation by a small molecule inverse receptor agonist. Front Immunol. 2022; 13:1033794.
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Opioid Addiction and Opioid Receptor Dimerization: Structural Modeling of the OPRD1 and OPRM1 Heterodimer and Its Signaling Pathways. Int J Mol Sci. 2021 Sep 24; 22(19).
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Reply to Schierwagen et al.: ?-Arrestins in liver disease. Proc Natl Acad Sci U S A. 2020 11 03; 117(44):27085-27086.
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Conformational Sensors and Domain Swapping Reveal Structural and Functional Differences between ?-Arrestin Isoforms. Cell Rep. 2019 09 24; 28(13):3287-3299.e6.
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Diverse Mechanisms Lead to Common Dysfunction of Striatal Cholinergic Interneurons in Distinct Genetic Mouse Models of Dystonia. J Neurosci. 2019 Sep 04; 39(36):7195-7205.
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Manifold roles of ?-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9. Sci Signal. 2018 09 25; 11(549).
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The Diverse Roles of Arrestin Scaffolds in G Protein-Coupled Receptor Signaling. Pharmacol Rev. 2017 07; 69(3):256-297.
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The conformational signature of ?-arrestin2 predicts its trafficking and signalling functions. Nature. 2016 Mar 31; 531(7596):665-8.
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NanoLuc Complementation Reporter Optimized for Accurate Measurement of Protein Interactions in Cells. ACS Chem Biol. 2016 Feb 19; 11(2):400-8.
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Arrestin-dependent angiotensin AT1 receptor signaling regulates Akt and mTor-mediated protein synthesis. J Biol Chem. 2014 Sep 19; 289(38):26155-26166.