Mitogen-Activated Protein Kinases
                             
                            
                            
                                
                                    
                                            
	"Mitogen-Activated Protein Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, 
	MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, 
	which enables searching at various levels of specificity.
	
	
		
			
			
				A superfamily of PROTEIN-SERINE-THREONINE KINASES that are activated by diverse stimuli via protein kinase cascades. They are the final components of the cascades, activated by phosphorylation by MITOGEN-ACTIVATED PROTEIN KINASE KINASES, which in turn are activated by mitogen-activated protein kinase kinase kinases (MAP KINASE KINASE KINASES).
    
			
			
				
				
					
						| Descriptor ID | D020928 | 
					
						| MeSH Number(s) | D08.811.913.696.620.682.700.567 D12.644.360.450 D12.776.476.450 | 
					
						| Concept/Terms | Mitogen-Activated Protein KinasesMitogen-Activated Protein KinasesKinases, Mitogen-Activated ProteinMitogen Activated Protein KinasesProtein Kinases, Mitogen-Activated
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				Below are MeSH descriptors whose meaning is more general than "Mitogen-Activated Protein Kinases".
				
			 
			
			
				Below are MeSH descriptors whose meaning is more specific than "Mitogen-Activated Protein Kinases".
				
			 
		 
	 
 
                                        
                                            
	
	
		
			
			
					
				This graph shows the total number of publications written about "Mitogen-Activated Protein Kinases" by people in this website by year, and whether "Mitogen-Activated Protein Kinases" was a major or minor topic of these publications. 
				
					 
                    To see the data from this visualization as text, 
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		            | Year | Major Topic | Minor Topic | Total | 
|---|
| 1995 | 3 | 0 | 3 | 
| 1996 | 6 | 0 | 6 | 
| 1997 | 3 | 0 | 3 | 
| 1998 | 9 | 1 | 10 | 
| 1999 | 10 | 3 | 13 | 
| 2000 | 14 | 9 | 23 | 
| 2001 | 8 | 12 | 20 | 
| 2002 | 9 | 6 | 15 | 
| 2003 | 14 | 15 | 29 | 
| 2004 | 9 | 7 | 16 | 
| 2005 | 4 | 2 | 6 | 
| 2006 | 2 | 4 | 6 | 
| 2007 | 5 | 2 | 7 | 
| 2008 | 0 | 3 | 3 | 
| 2009 | 1 | 3 | 4 | 
| 2010 | 2 | 1 | 3 | 
| 2011 | 1 | 4 | 5 | 
| 2012 | 3 | 3 | 6 | 
| 2013 | 0 | 1 | 1 | 
| 2014 | 2 | 0 | 2 | 
| 2015 | 0 | 4 | 4 | 
| 2016 | 1 | 0 | 1 | 
| 2019 | 1 | 0 | 1 | 
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				Below are the most recent publications written about "Mitogen-Activated Protein Kinases" by people in Profiles.
						
					
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								The Pathogenesis of Port Wine Stain and Sturge Weber Syndrome: Complex Interactions between Genetic Alterations and Aberrant MAPK and PI3K Activation. Int J Mol Sci. 2019 May 07; 20(9). 
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								Delayed Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Inhibition by Trametinib Attenuates Systemic Inflammatory Responses and Multiple Organ Injury in Murine Sepsis. Crit Care Med. 2016 08; 44(8):e711-20. 
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								High-fat diet increases O-GlcNAc levels in cerebral arteries: a link to vascular dysfunction associated with hyperlipidaemia/obesity? Clin Sci (Lond). 2016 06 01; 130(11):871-80. 
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								A critical role of cardiac fibroblast-derived exosomes in activating renin angiotensin system in cardiomyocytes. J Mol Cell Cardiol. 2015 Dec; 89(Pt B):268-79. 
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								Prostaglandin E2 Promotes Colorectal Cancer Stem Cell Expansion and Metastasis in Mice. Gastroenterology. 2015 Dec; 149(7):1884-1895.e4. 
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								GPR40/FFA1 and neutral sphingomyelinase are involved in palmitate-boosted inflammatory response of microvascular endothelial cells to LPS. Atherosclerosis. 2015 May; 240(1):163-73. 
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								Coronin-1 and calcium signaling governs sympathetic final target innervation. J Neurosci. 2015 Mar 04; 35(9):3893-902. 
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								Exocyst Sec10 protects renal tubule cells from injury by EGFR/MAPK activation and effects on endocytosis. Am J Physiol Renal Physiol. 2014 Dec 15; 307(12):F1334-41. 
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								Novel MAPK-dependent and -independent tubulogenes identified via microarray analysis of 3D-cultured Madin-Darby canine kidney cells. Am J Physiol Renal Physiol. 2014 May 01; 306(9):F1047-58. 
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								2'-hydroxy C16-ceramide induces apoptosis-associated proteomic changes in C6 glioma cells. J Proteome Res. 2013 Oct 04; 12(10):4366-75.