"Zinc Finger Protein Gli3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A zinc finger transcription factor that contains five CYS2-HIS2 ZINC FINGERS and binds to the GLI consensus sequence 5'-GGGTGGTC-3'. The full-length protein functions as a transcriptional activator whereas the truncated C-terminal form functions as a transcriptional repressor of the Sonic Hedgehog (Shh) signaling pathway; a balance between these two forms is critical for limb and digit development. GLI3 also plays a critical role in the differentiation and proliferation of CHONDROCYTES.
| Descriptor ID |
D000074290
|
| MeSH Number(s) |
D12.776.260.522.875 D12.776.260.703.900 D12.776.930.375.875 D12.776.930.780.972
|
| Concept/Terms |
Zinc Finger Protein Gli3- Zinc Finger Protein Gli3
- Glioma-Associated Oncogene Family Zinc Finger 3 Protein
- Glioma Associated Oncogene Family Zinc Finger 3 Protein
- GLI-Kruppel Family Member 3 Protein
- GLI Kruppel Family Member 3 Protein
|
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