"CCCTC-Binding Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A repressor protein with poly(ADP)-ribose binding activity that binds CHROMATIN and DNA; its structure consisting of 11 CYS2-HIS2 ZINC FINGERS allows it to recognize many different DNA target sites. It functions as a repressor by binding to INSULATOR ELEMENTS and preventing interaction between promoters and nearby enhancers and silencers. It plays a critical role in EPIGENETIC PROCESSES, including GENOMIC IMPRINTING.
| Descriptor ID |
D000076246
|
| MeSH Number(s) |
D12.776.157.687.157 D12.776.260.120 D12.776.660.235.050 D12.776.660.720.157 D12.776.664.235.050 D12.776.930.780.563
|
| Concept/Terms |
CCCTC-Binding Factor- CCCTC-Binding Factor
- CCCTC Binding Factor
- DNA-Binding Protein CTCF
- CTCF, DNA-Binding Protein
- DNA Binding Protein CTCF
- CTCF Protein
|
Below are MeSH descriptors whose meaning is more general than "CCCTC-Binding Factor".
Below are MeSH descriptors whose meaning is more specific than "CCCTC-Binding Factor".
This graph shows the total number of publications written about "CCCTC-Binding Factor" by people in this website by year, and whether "CCCTC-Binding Factor" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2018 | 1 | 1 | 2 |
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Below are the most recent publications written about "CCCTC-Binding Factor" by people in Profiles.
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NF-?B inhibition rescues cardiac function by remodeling calcium genes in a Duchenne muscular dystrophy model. Nat Commun. 2018 08 24; 9(1):3431.
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Dopamine Triggers CTCF-Dependent Morphological and Genomic Remodeling of Astrocytes. J Neurosci. 2018 05 23; 38(21):4846-4858.
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Tissue-specific targeting of cell fate regulatory genes by E2f factors. Cell Death Differ. 2016 Apr; 23(4):565-75.
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An insulator loop resides between the synthetically interacting elements of the human/rat conserved breast cancer susceptibility locus MCS5A/Mcs5a. Nucleic Acids Res. 2012 Jan; 40(1):132-47.