Zinc Finger E-box Binding Homeobox 2
"Zinc Finger E-box Binding Homeobox 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A transcription factor that consists of 8 CYS2-HIS2 ZINC FINGERS flanking a central HOMEOBOX. It binds to the 5'-CACCT-3' DNA sequence located within E-BOX ELEMENTS of many genes essential for embryonic growth and development and regulates their activity; it represses transcription of the E-CADHERIN gene. Mutations in the ZEB2 gene are associated with MOWAT-WILSON SYNDROME.
| Descriptor ID |
D000074165
|
| MeSH Number(s) |
D12.776.260.400.883 D12.776.260.703.700 D12.776.930.780.918
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| Concept/Terms |
Zinc Finger E-box Binding Homeobox 2- Zinc Finger E-box Binding Homeobox 2
- Zinc Finger E box Binding Homeobox 2
- Zinc Finger E-box Binding Homeobox 2 Protein
- Zinc Finger E box Binding Homeobox 2 Protein
- Zeb2 Transcription Factor
- Transcription Factor, Zeb2
- Smad-Interacting Protein 1
- Smad Interacting Protein 1
|
Below are MeSH descriptors whose meaning is more general than "Zinc Finger E-box Binding Homeobox 2".
Below are MeSH descriptors whose meaning is more specific than "Zinc Finger E-box Binding Homeobox 2".
This graph shows the total number of publications written about "Zinc Finger E-box Binding Homeobox 2" by people in this website by year, and whether "Zinc Finger E-box Binding Homeobox 2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
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Below are the most recent publications written about "Zinc Finger E-box Binding Homeobox 2" by people in Profiles.
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Mitochondrial SOD2 regulates epithelial-mesenchymal transition and cell populations defined by differential CD44 expression. Oncogene. 2015 Oct 08; 34(41):5229-39.
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Langerhans cell maturation is accompanied by induction of N-cadherin and the transcriptional regulators of epithelial-mesenchymal transition ZEB1/2. Eur J Immunol. 2014 Feb; 44(2):553-60.
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A NOTCH3-mediated squamous cell differentiation program limits expansion of EMT-competent cells that express the ZEB transcription factors. Cancer Res. 2011 Nov 01; 71(21):6836-47.
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ZEB1-responsive genes in non-small cell lung cancer. Cancer Lett. 2011 Jan 01; 300(1):66-78.
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Epidermal growth factor receptor and mutant p53 expand an esophageal cellular subpopulation capable of epithelial-to-mesenchymal transition through ZEB transcription factors. Cancer Res. 2010 May 15; 70(10):4174-84.
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Induction of E-cadherin in lung cancer and interaction with growth suppression by histone deacetylase inhibition. J Thorac Oncol. 2009 Dec; 4(12):1455-65.