"Calcimycin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An ionophorous, polyether antibiotic from Streptomyces chartreusensis. It binds and transports CALCIUM and other divalent cations across membranes and uncouples oxidative phosphorylation while inhibiting ATPase of rat liver mitochondria. The substance is used mostly as a biochemical tool to study the role of divalent cations in various biological systems.
| Descriptor ID |
D000001
|
| MeSH Number(s) |
D03.633.100.221.173
|
| Concept/Terms |
A-23187- A-23187
- A 23187
- A23187
- Antibiotic A23187
- A23187, Antibiotic
|
Below are MeSH descriptors whose meaning is more general than "Calcimycin".
Below are MeSH descriptors whose meaning is more specific than "Calcimycin".
This graph shows the total number of publications written about "Calcimycin" by people in this website by year, and whether "Calcimycin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 0 | 1 | 1 |
| 1995 | 0 | 2 | 2 |
| 1998 | 0 | 2 | 2 |
| 1999 | 2 | 0 | 2 |
| 2000 | 0 | 1 | 1 |
| 2003 | 0 | 2 | 2 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 2 | 2 |
| 2007 | 0 | 1 | 1 |
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Below are the most recent publications written about "Calcimycin" by people in Profiles.
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Lee SH, Rangiah K, Williams MV, Wehr AY, DuBois RN, Blair IA. Cyclooxygenase-2-mediated metabolism of arachidonic acid to 15-oxo-eicosatetraenoic acid by rat intestinal epithelial cells. Chem Res Toxicol. 2007 Nov; 20(11):1665-75.
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Lakshminrusimha S, Russell JA, Steinhorn RH, Ryan RM, Gugino SF, Morin FC, Swartz DD, Kumar VH. Pulmonary arterial contractility in neonatal lambs increases with 100% oxygen resuscitation. Pediatr Res. 2006 Jan; 59(1):137-41.
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Lee SH, Williams MV, Dubois RN, Blair IA. Cyclooxygenase-2-mediated DNA damage. J Biol Chem. 2005 Aug 05; 280(31):28337-46.
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Sharma AK, Rohrer B. Calcium-induced calpain mediates apoptosis via caspase-3 in a mouse photoreceptor cell line. J Biol Chem. 2004 Aug 20; 279(34):35564-72.
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Pettus BJ, Bielawska A, Spiegel S, Roddy P, Hannun YA, Chalfant CE. Ceramide kinase mediates cytokine- and calcium ionophore-induced arachidonic acid release. J Biol Chem. 2003 Oct 03; 278(40):38206-13.
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Oh KW, Qian T, Brenner DA, Lemasters JJ. Salicylate enhances necrosis and apoptosis mediated by the mitochondrial permeability transition. Toxicol Sci. 2003 May; 73(1):44-52.
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Ray SK, Fidan M, Nowak MW, Wilford GG, Hogan EL, Banik NL. Oxidative stress and Ca2+ influx upregulate calpain and induce apoptosis in PC12 cells. Brain Res. 2000 Jan 10; 852(2):326-34.
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Ray SK, Wilford GG, Crosby CV, Hogan EL, Banik NL. Diverse stimuli induce calpain overexpression and apoptosis in C6 glioma cells. Brain Res. 1999 May 22; 829(1-2):18-27.
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Qian T, Herman B, Lemasters JJ. The mitochondrial permeability transition mediates both necrotic and apoptotic death of hepatocytes exposed to Br-A23187. Toxicol Appl Pharmacol. 1999 Jan 15; 154(2):117-25.
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Lemasters JJ, Nieminen AL, Qian T, Trost LC, Elmore SP, Nishimura Y, Crowe RA, Cascio WE, Bradham CA, Brenner DA, Herman B. The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy. Biochim Biophys Acta. 1998 Aug 10; 1366(1-2):177-96.