"Phosphofructokinase-2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An allosteric enzyme that regulates glycolysis and gluconeogenesis by catalyzing the transfer of a phosphate group from ATP to fructose-6-phosphate to yield fructose-2,6-bisphosphate, an allosteric effector for the other 6-phosphofructokinase, PHOSPHOFRUCTOKINASE-1. Phosphofructokinase-2 is bifunctional: the dephosphorylated form is a kinase and the phosphorylated form is a phosphatase that breaks down fructose-2,6-bisphosphate to yield fructose-6-phosphate.
| Descriptor ID |
D025481
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| MeSH Number(s) |
D08.811.277.352.650.622 D08.811.641.843 D08.811.913.696.620.225.850.750
|
| Concept/Terms |
Phosphofructokinase-2- Phosphofructokinase-2
- Phosphofructokinase 2
- ATP-D-Fructose-6-phosphate 2-phosphotransferase
- 6-Phosphofructo-2-kinase
- Fructose-6-P,2-kinase
- Fructose-6-phosphate,2-kinase
- 6PF2K
- Fru-6-P,2-kinase
Fructose-2,6-bisphosphatase- Fructose-2,6-bisphosphatase
- Fructose-2,6-bisphosphate 2-phosphatase
- fructose-2,6-diphosphatase
- Fructose 2,6-bisphosphatase
6-Phosphofructo-2-kinase-fructose-2,6-bisphosphatase- 6-Phosphofructo-2-kinase-fructose-2,6-bisphosphatase
- 6-Phosphofructo 2-kinase-fructose 2,6-bisphosphatase
- Fructose-6-phosphate,2-kinase-fructose-2,6-bisphosphatase
- 6-PF-2-K-Fru-2,6-P(2)ase
- F Kinase-F-bisphosphatase
- Fru-kinase-Fru-bisphosphatase
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Below are MeSH descriptors whose meaning is more general than "Phosphofructokinase-2".
Below are MeSH descriptors whose meaning is more specific than "Phosphofructokinase-2".
This graph shows the total number of publications written about "Phosphofructokinase-2" by people in this website by year, and whether "Phosphofructokinase-2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2016 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Phosphofructokinase-2" by people in Profiles.
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Killoy KM, Pehar M, Harlan BA, Vargas MR. Altered expression of clock and clock-controlled genes in a hSOD1-linked amyotrophic lateral sclerosis mouse model. FASEB J. 2021 02; 35(2):e21343.
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Kovacs L, Cao Y, Han W, Meadows L, Kovacs-Kasa A, Kondrikov D, Verin AD, Barman SA, Dong Z, Huo Y, Su Y. PFKFB3 in Smooth Muscle Promotes Vascular Remodeling in Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 2019 09 01; 200(5):617-627.
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Nguyen HD, Chatterjee S, Haarberg KM, Wu Y, Bastian D, Heinrichs J, Fu J, Daenthanasanmak A, Schutt S, Shrestha S, Liu C, Wang H, Chi H, Mehrotra S, Yu XZ. Metabolic reprogramming of alloantigen-activated T cells after hematopoietic cell transplantation. J Clin Invest. 2016 Apr 01; 126(4):1337-52.