Unfolded Protein Response

"Unfolded Protein Response" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A cellular response to environmental insults that cause disruptions in PROTEIN FOLDING and/or accumulation of defectively folded protein in the ENDOPLASMIC RETICULUM. It consists of a group of regulatory cascades that are triggered as a response to altered levels of calcium and/or the redox state of the endoplasmic reticulum. Persistent activation of the unfolded protein response leads to the induction of APOPTOSIS.

Descriptor ID	D056811
MeSH Number(s)	G02.111.660.871.790.600.962 G02.111.691.600.850 G03.734.871.790.600.850 G05.308.670.600.850
Concept/Terms	Unfolded Protein Response Unfolded Protein Response Protein Response, Unfolded Protein Responses, Unfolded Response, Unfolded Protein Responses, Unfolded Protein Unfolded Protein Responses

Below are MeSH descriptors whose meaning is more general than "Unfolded Protein Response".

Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Peptide Biosynthesis [G02.111.660]
Protein Biosynthesis [G02.111.660.871]
Protein Modification, Translational [G02.111.660.871.790]
Protein Processing, Post-Translational [G02.111.660.871.790.600]
Unfolded Protein Response [G02.111.660.871.790.600.962]
Protein Modification, Translational [G02.111.691]
Protein Processing, Post-Translational [G02.111.691.600]
Unfolded Protein Response [G02.111.691.600.850]
Metabolism [G03]
Peptide Biosynthesis [G03.734]
Protein Biosynthesis [G03.734.871]
Protein Modification, Translational [G03.734.871.790]
Protein Processing, Post-Translational [G03.734.871.790.600]
Unfolded Protein Response [G03.734.871.790.600.850]
Genetic Phenomena [G05]
Gene Expression Regulation [G05.308]
Protein Modification, Translational [G05.308.670]
Protein Processing, Post-Translational [G05.308.670.600]
Unfolded Protein Response [G05.308.670.600.850]

Below are MeSH descriptors whose meaning is related to "Unfolded Protein Response".

Below are MeSH descriptors whose meaning is more specific than "Unfolded Protein Response".

Unfolded Protein Response
Endoplasmic Reticulum-Associated Degradation

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Unfolded Protein Response" by people in this website by year, and whether "Unfolded Protein Response" was a major or minor topic of these publications.

Bar chart showing 39 publications over 12 distinct years, with a maximum of 8 publications in 2016 and 2019

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2009	0	1	1
2010	0	2	2
2012	2	1	3
2013	1	1	2
2014	0	1	1
2015	2	1	3
2016	3	5	8
2017	1	3	4
2019	5	3	8
2020	1	1	2
2021	1	3	4
2022	1	0	1

Below are the most recent publications written about "Unfolded Protein Response" by people in Profiles.

Liu X, Taylor SA, Gromer KD, Zhang D, Hubchak SC, LeCuyer BE, Iwawaki T, Shi Z, Rockey DC, Green RM. Mechanisms of liver injury in high fat sugar diet fed mice that lack hepatocyte X-box binding protein 1. PLoS One. 2022; 17(1):e0261789.

View in: PubMed
Zhang Y, Lim CU, Sikirzhytski V, Naderi A, Chatzistamou I, Kiaris H. Propensity to endoplasmic reticulum stress in deer mouse fibroblasts predicts skin inflammation and body weight gain. Dis Model Mech. 2021 10 01; 14(10).

View in: PubMed
Rozpedek-Kaminska W, Galita G, Siwecka N, Carroll SL, Diehl JA, Kucharska E, Pytel D, Majsterek I. The Potential Role of Small-Molecule PERK Inhibitor LDN-0060609 in Primary Open-Angle Glaucoma Treatment. Int J Mol Sci. 2021 Apr 26; 22(9).

View in: PubMed
Diteepeng T, Del Monte F, Luciani M. The long and winding road to target protein misfolding in cardiovascular diseases. Eur J Clin Invest. 2021 May; 51(5):e13504.

View in: PubMed
Zhang L, Kim SH, Park KH, Zhi-Wei Y, Jie Z, Townsend DM, Tew KD. Glutathione S-Transferase P Influences Redox Homeostasis and Response to Drugs that Induce the Unfolded Protein Response in Zebrafish. J Pharmacol Exp Ther. 2021 04; 377(1):121-132.

View in: PubMed
Mohamed E, Sierra RA, Trillo-Tinoco J, Cao Y, Innamarato P, Payne KK, de Mingo Pulido A, Mandula J, Zhang S, Thevenot P, Biswas S, Abdalla SK, Costich TL, Hänggi K, Anadon CM, Flores ER, Haura EB, Mehrotra S, Pilon-Thomas S, Ruffell B, Munn DH, Cubillos-Ruiz JR, Conejo-Garcia JR, Rodriguez PC. The Unfolded Protein Response Mediator PERK Governs Myeloid Cell-Driven Immunosuppression in Tumors through Inhibition of STING Signaling. Immunity. 2020 04 14; 52(4):668-682.e7.

View in: PubMed
Rozpedek-Kaminska W, Siwecka N, Wawrzynkiewicz A, Wojtczak R, Pytel D, Diehl JA, Majsterek I. The PERK-Dependent Molecular Mechanisms as a Novel Therapeutic Target for Neurodegenerative Diseases. Int J Mol Sci. 2020 Mar 19; 21(6).

View in: PubMed
Hurst KE, Lawrence KA, Reyes Angeles L, Ye Z, Zhang J, Townsend DM, Dolloff N, Thaxton JE. Endoplasmic Reticulum Protein Disulfide Isomerase Shapes T Cell Efficacy for Adoptive Cellular Therapy of Tumors. Cells. 2019 11 26; 8(12).

View in: PubMed
Siwecka N, Rozpedek W, Pytel D, Wawrzynkiewicz A, Dziki A, Dziki L, Diehl JA, Majsterek I. Dual role of Endoplasmic Reticulum Stress-Mediated Unfolded Protein Response Signaling Pathway in Carcinogenesis. Int J Mol Sci. 2019 Sep 05; 20(18).

View in: PubMed
Zhang L, Zhang J, Ye Z, Manevich Y, Ball LE, Bethard JR, Jiang YL, Broome AM, Dalton AC, Wang GY, Townsend DM, Tew KD. Isoflavone ME-344 Disrupts Redox Homeostasis and Mitochondrial Function by Targeting Heme Oxygenase 1. Cancer Res. 2019 08 15; 79(16):4072-4085.

View in: PubMed

People

Explore

Similar Concepts

Top Journals