Epistasis, Genetic

"Epistasis, Genetic" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A form of gene interaction whereby the expression of one gene interferes with or masks the expression of a different gene or genes. Genes whose expression interferes with or masks the effects of other genes are said to be epistatic to the effected genes. Genes whose expression is affected (blocked or masked) are hypostatic to the interfering genes.

Descriptor ID	D004843
MeSH Number(s)	G05.308.207
Concept/Terms	Epistasis, Genetic Epistasis, Genetic Epistases, Genetic Gene-Gene Interactions, Epistatic Gene Gene Interactions, Epistatic Gene-Gene Interaction, Epistatic Epistatic Gene-Gene Interaction Epistatic Gene-Gene Interactions Gene Gene Interaction, Epistatic Interaction, Epistatic Gene-Gene Interactions, Epistatic Gene-Gene Non-Allelic Gene Interactions Gene Interaction, Non-Allelic Gene Interactions, Non-Allelic Interaction, Non-Allelic Gene Interactions, Non-Allelic Gene Non Allelic Gene Interactions Non-Allelic Gene Interaction Genetic Epistasis Genetic Epistases Genes, Epistatic Genes, Epistatic Epistatic Gene Epistatic Genes Gene, Epistatic Genes, Hypostatic Genes, Hypostatic Gene, Hypostatic Hypostatic Gene Hypostatic Genes Deviation, Epistatic Deviation, Epistatic Interaction Deviation Epistatic Deviation

Below are MeSH descriptors whose meaning is more general than "Epistasis, Genetic".

Biological Sciences [G]
Genetic Phenomena [G05]
Gene Expression Regulation [G05.308]
Epistasis, Genetic [G05.308.207]

Below are MeSH descriptors whose meaning is more specific than "Epistasis, Genetic".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Epistasis, Genetic" by people in this website by year, and whether "Epistasis, Genetic" was a major or minor topic of these publications.

Bar chart showing 25 publications over 11 distinct years, with a maximum of 4 publications in 2011 and 2015

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2001	0	1	1
2003	1	1	2
2004	2	1	3
2006	0	1	1
2007	0	3	3
2010	0	1	1
2011	2	2	4
2012	2	0	2
2013	1	2	3
2015	2	2	4
2018	0	1	1

Below are the most recent publications written about "Epistasis, Genetic" by people in Profiles.

Pandey JP, Namboodiri AM, Armeson KE, Iwasaki M, Kasuga Y, Hamada GS, Tsugane S. IGHG, IGKC, and FCGR genes and endogenous antibody responses to GARP in patients with breast cancer and matched controls. Hum Immunol. 2018 Aug; 79(8):632-637.

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Hohman TJ, Bush WS, Jiang L, Brown-Gentry KD, Torstenson ES, Dudek SM, Mukherjee S, Naj A, Kunkle BW, Ritchie MD, Martin ER, Schellenberg GD, Mayeux R, Farrer LA, Pericak-Vance MA, Haines JL, Thornton-Wells TA. Discovery of gene-gene interactions across multiple independent data sets of late onset Alzheimer disease from the Alzheimer Disease Genetics Consortium. Neurobiol Aging. 2016 Feb; 38:141-150.

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Ebbert MTW, Boehme KL, Wadsworth ME, Staley LA, Mukherjee S, Crane PK, Ridge PG, Kauwe JSK. Interaction between variants in CLU and MS4A4E modulates Alzheimer's disease risk. Alzheimers Dement. 2016 Feb; 12(2):121-129.

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Moraru M, Black LE, Muntasell A, Portero F, López-Botet M, Reyburn HT, Pandey JP, Vilches C. NK Cell and Ig Interplay in Defense against Herpes Simplex Virus Type 1: Epistatic Interaction of CD16A and IgG1 Allotypes of Variable Affinities Modulates Antibody-Dependent Cellular Cytotoxicity and Susceptibility to Clinical Reactivation. J Immunol. 2015 Aug 15; 195(4):1676-84.

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Cuchra M, Markiewicz L, Mucha B, Pytel D, Szymanek K, Szemraj J, Szaflik J, Szaflik JP, Majsterek I. The role of base excision repair in the development of primary open angle glaucoma in the Polish population. Mutat Res. 2015 Aug; 778:26-40.

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Liu D, Wang CJ, Judge DP, Halushka MK, Ni J, Habashi JP, Moslehi J, Bedja D, Gabrielson KL, Xu H, Qian F, Huso D, Dietz HC, Germino GG, Watnick T. A Pkd1-Fbn1 genetic interaction implicates TGF-ß signaling in the pathogenesis of vascular complications in autosomal dominant polycystic kidney disease. J Am Soc Nephrol. 2014 Jan; 25(1):81-91.

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Pandey JP, Kistner-Griffin E, Namboodiri AM, Black L, Jobim M. Suggestive evidence that Fc variants of IgG2 and Fc?RIIa loci interact to contribute to the risk of prostate cancer. Hum Immunol. 2013 Dec; 74(12):1656-8.

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Reitz C, Tosto G, Vardarajan B, Rogaeva E, Ghani M, Rogers RS, Conrad C, Haines JL, Pericak-Vance MA, Fallin MD, Foroud T, Farrer LA, Schellenberg GD, George-Hyslop PS, Mayeux R. Independent and epistatic effects of variants in VPS10-d receptors on Alzheimer disease risk and processing of the amyloid precursor protein (APP). Transl Psychiatry. 2013 May 14; 3:e256.

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Wolf BJ, Hill EG, Slate EH, Neumann CA, Kistner-Griffin E. LBoost: A boosting algorithm with application for epistasis discovery. PLoS One. 2012; 7(11):e47281.

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Hughes T, Adler A, Kelly JA, Kaufman KM, Williams AH, Langefeld CD, Brown EE, Alarcón GS, Kimberly RP, Edberg JC, Ramsey-Goldman R, Petri M, Boackle SA, Stevens AM, Reveille JD, Sanchez E, Martín J, Niewold TB, Vilá LM, Scofield RH, Gilkeson GS, Gaffney PM, Criswell LA, Moser KL, Merrill JT, Jacob CO, Tsao BP, James JA, Vyse TJ, Alarcón-Riquelme ME, Harley JB, Richardson BC, Sawalha AH. Evidence for gene-gene epistatic interactions among susceptibility loci for systemic lupus erythematosus. Arthritis Rheum. 2012 Feb; 64(2):485-92.

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