beta-Lactams

"beta-Lactams" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Four-membered cyclic AMIDES, best known for the PENICILLINS based on a bicyclo-thiazolidine, as well as the CEPHALOSPORINS based on a bicyclo-thiazine, and including monocyclic MONOBACTAMS. The BETA-LACTAMASES hydrolyze the beta lactam ring, accounting for BETA-LACTAM RESISTANCE of infective bacteria.

Descriptor ID	D047090
MeSH Number(s)	D02.065.589.099 D02.886.108 D03.633.100.300
Concept/Terms	beta-Lactams beta-Lactams beta Lactams 4-Thia-1-Azabicyclo(4.2.0)Octanes 4-Thia-1-Azabicyclo(4.2.0)Octanes 4-Thia-1-Azabicyclo(3.2.0)Heptanes 4-Thia-1-Azabicyclo(3.2.0)Heptanes

Below are MeSH descriptors whose meaning is more general than "beta-Lactams".

Chemicals and Drugs [D]
Organic Chemicals [D02]
Amides [D02.065]
Lactams [D02.065.589]
beta-Lactams [D02.065.589.099]
Sulfur Compounds [D02.886]
beta-Lactams [D02.886.108]
Heterocyclic Compounds [D03]
Heterocyclic Compounds, Fused-Ring [D03.633]
Heterocyclic Compounds, 2-Ring [D03.633.100]
beta-Lactams [D03.633.100.300]

Below are MeSH descriptors whose meaning is related to "beta-Lactams".

Below are MeSH descriptors whose meaning is more specific than "beta-Lactams".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "beta-Lactams" by people in this website by year, and whether "beta-Lactams" was a major or minor topic of these publications.

Bar chart showing 17 publications over 10 distinct years, with a maximum of 5 publications in 2016

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2005	1	0	1
2009	1	1	2
2010	1	0	1
2014	0	1	1
2016	4	1	5
2017	1	0	1
2018	2	0	2
2019	0	2	2
2021	0	1	1
2022	0	1	1

Below are the most recent publications written about "beta-Lactams" by people in Profiles.

VanDevanter DR, West NE, Sanders DB, Skalland M, Goss CH, Flume PA, Heltshe SL. Antipseudomonal treatment decisions during CF exacerbation management. J Cyst Fibros. 2022 Sep; 21(5):753-758.

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Li Y, Zhu Y, Zhou W, Chen Z, Moran RA, Ke H, Feng Y, van Schaik W, Shen H, Ji J, Ruan Z, Hua X, Yu Y. Alcaligenes faecalis metallo-ß-lactamase in extensively drug-resistant Pseudomonas aeruginosa isolates. Clin Microbiol Infect. 2022 Jun; 28(6):880.e1-880.e8.

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Al-Hasan MN, Gould AP, Drennan C, Hill O, Justo JA, Kohn J, Bookstaver PB. Empirical fluoroquinolones versus broad-spectrum beta-lactams for Gram-negative bloodstream infections in the absence of antimicrobial resistance risk factors. J Glob Antimicrob Resist. 2020 09; 22:87-93.

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Seddon MM, Bookstaver PB, Justo JA, Kohn J, Rac H, Haggard E, Mediwala KN, Dash S, Al-Hasan MN. Role of Early De-escalation of Antimicrobial Therapy on Risk of Clostridioides difficile Infection Following Enterobacteriaceae Bloodstream Infections. Clin Infect Dis. 2019 07 18; 69(3):414-420.

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Nguyen S, Lefébure A, Lescure FX, Arnaud P, Rioux C. Evaluation of broad-spectrum beta-lactam prescriptions (except carbapenems) in a French teaching hospital. Med Mal Infect. 2018 Dec; 48(8):509-515.

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Al-Jaghbeer MJ, Justo JA, Owens W, Kohn J, Bookstaver PB, Hucks J, Al-Hasan MN. Risk factors for pneumonia due to beta-lactam-susceptible and beta-lactam-resistant Pseudomonas aeruginosa: a case-case-control study. Infection. 2018 Aug; 46(4):487-494.

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Carosso S, Liu R, Miller PA, Hecker SJ, Glinka T, Miller MJ. Methodology for Monobactam Diversification: Syntheses and Studies of 4-Thiomethyl Substituted ß-Lactams with Activity against Gram-Negative Bacteria, Including Carbapenemase Producing Acinetobacter baumannii. J Med Chem. 2017 11 09; 60(21):8933-8944.

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Chen W, Zhang YM, Davies C. Penicillin-Binding Protein 3 Is Essential for Growth of Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2017 01; 61(1).

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Majewski MW, Miller PA, Oliver AG, Miller MJ. Alternate "Drug" Delivery Utilizing ß-Lactam Cores: Syntheses and Biological Evaluation of ß-Lactams Bearing Isocyanate Precursors. J Org Chem. 2017 01 06; 82(1):737-744.

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Augustine MR, Testerman TL, Justo JA, Bookstaver PB, Kohn J, Albrecht H, Al-Hasan MN. Clinical Risk Score for Prediction of Extended-Spectrum ß-Lactamase-Producing Enterobacteriaceae in Bloodstream Isolates. Infect Control Hosp Epidemiol. 2017 03; 38(3):266-272.

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