"Receptors, Death Domain" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of cell surface receptors that signal via a conserved domain that extends into the cell CYTOPLASM. The conserved domain is referred to as a DEATH DOMAIN due to the fact that many of these receptors are involved in APOPTOSIS signaling pathways. Several DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS can bind to the death domains of the activated receptors and through a complex series of interactions activate apoptotic mediators such as CASPASES.
|Receptors, Death Domain
- Receptors, Death Domain
- Death Receptors
- Death Domain Receptors
- Receptors, Death Domain Family
- Receptors, DR Family
- DR Family Receptors
Below are MeSH descriptors whose meaning is more general than "Receptors, Death Domain".
Below are MeSH descriptors whose meaning is more specific than "Receptors, Death Domain".
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Below are the most recent publications written about "Receptors, Death Domain" by people in Profiles.
Vargas MR, Johnson JA. Astrogliosis in amyotrophic lateral sclerosis: role and therapeutic potential of astrocytes. Neurotherapeutics. 2010 Oct; 7(4):471-81.
Wang P, Song JH, Song DK, Zhang J, Hao C. Role of death receptor and mitochondrial pathways in conventional chemotherapy drug induction of apoptosis. Cell Signal. 2006 Sep; 18(9):1528-35.