Phosphodiesterase Inhibitors

"Phosphodiesterase Inhibitors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Compounds which inhibit or antagonize the biosynthesis or actions of phosphodiesterases.

Descriptor ID	D010726
MeSH Number(s)	D27.505.519.389.735
Concept/Terms	Phosphodiesterase Inhibitors Phosphodiesterase Inhibitors Phosphodiesterase Antagonists Phosphoric Diester Hydrolase Inhibitors Antiphosphodiesterases

Below are MeSH descriptors whose meaning is more general than "Phosphodiesterase Inhibitors".

Chemicals and Drugs [D]
Chemical Actions and Uses [D27]
Pharmacologic Actions [D27.505]
Molecular Mechanisms of Pharmacological Action [D27.505.519]
Enzyme Inhibitors [D27.505.519.389]
Phosphodiesterase Inhibitors [D27.505.519.389.735]

Below are MeSH descriptors whose meaning is related to "Phosphodiesterase Inhibitors".

Below are MeSH descriptors whose meaning is more specific than "Phosphodiesterase Inhibitors".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Phosphodiesterase Inhibitors" by people in this website by year, and whether "Phosphodiesterase Inhibitors" was a major or minor topic of these publications.

Bar chart showing 22 publications over 15 distinct years, with a maximum of 2 publications in 1999 and 2002 and 2006 and 2007 and 2008 and 2010 and 2012

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	1	0	1
1996	0	1	1
1999	1	1	2
2001	1	0	1
2002	0	2	2
2003	0	1	1
2004	0	1	1
2005	1	0	1
2006	1	1	2
2007	0	2	2
2008	2	0	2
2009	0	1	1
2010	1	1	2
2012	0	2	2
2013	1	0	1

Below are the most recent publications written about "Phosphodiesterase Inhibitors" by people in Profiles.

Bell RL, Lopez MF, Cui C, Egli M, Johnson KW, Franklin KM, Becker HC. Ibudilast reduces alcohol drinking in multiple animal models of alcohol dependence. Addict Biol. 2015 Jan; 20(1):38-42.

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Xin W, Soder RP, Cheng Q, Rovner ES, Petkov GV. Selective inhibition of phosphodiesterase 1 relaxes urinary bladder smooth muscle: role for ryanodine receptor-mediated BK channel activation. Am J Physiol Cell Physiol. 2012 Nov 15; 303(10):C1079-89.

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Xin W, Cheng Q, Soder RP, Rovner ES, Petkov GV. Constitutively active phosphodiesterase activity regulates urinary bladder smooth muscle function: critical role of KCa1.1 channel. Am J Physiol Renal Physiol. 2012 Nov 01; 303(9):F1300-6.

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Kumar VH, Swartz DD, Rashid N, Lakshminrusimha S, Ma C, Ryan RM, Morin FC. Prostacyclin and milrinone by aerosolization improve pulmonary hemodynamics in newborn lambs with experimental pulmonary hypertension. J Appl Physiol (1985). 2010 Sep; 109(3):677-84.

View in: PubMed
Zhou H, Lillis S, Loy RE, Ghassemi F, Rose MR, Norwood F, Mills K, Al-Sarraj S, Lane RJ, Feng L, Matthews E, Sewry CA, Abbs S, Buk S, Hanna M, Treves S, Dirksen RT, Meissner G, Muntoni F, Jungbluth H. Multi-minicore disease and atypical periodic paralysis associated with novel mutations in the skeletal muscle ryanodine receptor (RYR1) gene. Neuromuscul Disord. 2010 Mar; 20(3):166-73.

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Paintlia AS, Paintlia MK, Singh I, Skoff RB, Singh AK. Combination therapy of lovastatin and rolipram provides neuroprotection and promotes neurorepair in inflammatory demyelination model of multiple sclerosis. Glia. 2009 Jan 15; 57(2):182-93.

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Tedford RJ, Hemnes AR, Russell SD, Wittstein IS, Mahmud M, Zaiman AL, Mathai SC, Thiemann DR, Hassoun PM, Girgis RE, Orens JB, Shah AS, Yuh D, Conte JV, Champion HC. PDE5A inhibitor treatment of persistent pulmonary hypertension after mechanical circulatory support. Circ Heart Fail. 2008 Nov; 1(4):213-9.

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Paintlia AS, Paintlia MK, Singh I, Singh AK. Combined medication of lovastatin with rolipram suppresses severity of experimental autoimmune encephalomyelitis. Exp Neurol. 2008 Dec; 214(2):168-80.

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Wingard C, Fulton D, Husain S. Altered penile vascular reactivity and erection in the Zucker obese-diabetic rat. J Sex Med. 2007 Mar; 4(2):348-62; discussion 362-3.

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Sharma AK, Rohrer B. Sustained elevation of intracellular cGMP causes oxidative stress triggering calpain-mediated apoptosis in photoreceptor degeneration. Curr Eye Res. 2007 Mar; 32(3):259-69.

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