Cytochrome P-450 Enzyme Inhibitors
"Cytochrome P-450 Enzyme Inhibitors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Drugs and compounds which inhibit or antagonize the biosynthesis or actions of CYTOCHROME P-450 ENZYMES.
| Descriptor ID |
D065607
|
| MeSH Number(s) |
D27.505.389.500 D27.505.519.389.335
|
| Concept/Terms |
Cytochrome P-450 Enzyme Inhibitors- Cytochrome P-450 Enzyme Inhibitors
- Cytochrome P 450 Enzyme Inhibitors
- P-450 Enzyme Inhibitors
- Enzyme Inhibitors, P-450
- Inhibitors, P-450 Enzyme
- P 450 Enzyme Inhibitors
- P450 Enzyme Inhibitors
- Enzyme Inhibitors, P450
- Inhibitors, P450 Enzyme
- Cytochrome P-450 Inhibitors
- Cytochrome P 450 Inhibitors
- Inhibitors, Cytochrome P-450
- P-450 Inhibitors, Cytochrome
Cytochrome P-450 Monooxygenase Inhibitors- Cytochrome P-450 Monooxygenase Inhibitors
- Cytochrome P 450 Monooxygenase Inhibitors
- Cytochrome P-450-Dependent Monooxygenase Inhibitors
- Cytochrome P 450 Dependent Monooxygenase Inhibitors
|
Below are MeSH descriptors whose meaning is more general than "Cytochrome P-450 Enzyme Inhibitors".
Below are MeSH descriptors whose meaning is more specific than "Cytochrome P-450 Enzyme Inhibitors".
This graph shows the total number of publications written about "Cytochrome P-450 Enzyme Inhibitors" by people in this website by year, and whether "Cytochrome P-450 Enzyme Inhibitors" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 1996 | 1 | 0 | 1 |
| 1997 | 1 | 0 | 1 |
| 1998 | 0 | 1 | 1 |
| 1999 | 1 | 0 | 1 |
| 2003 | 0 | 1 | 1 |
| 2004 | 1 | 0 | 1 |
| 2005 | 1 | 0 | 1 |
| 2008 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
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Below are the most recent publications written about "Cytochrome P-450 Enzyme Inhibitors" by people in Profiles.
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The effects of milk thistle (Silybum marianum) on human cytochrome P450 activity. Drug Metab Dispos. 2014 Oct; 42(10):1611-6.
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Discovery of 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a novel and potent vascular endothelial growth factor receptor inhibitor. J Med Chem. 2008 Aug 14; 51(15):4632-40.
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Lack of effect of ketoconazole-mediated CYP3A inhibition on sorafenib clinical pharmacokinetics. Cancer Chemother Pharmacol. 2006 May; 57(5):685-92.
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Comparative CYP3A4 inhibitory effects of venlafaxine, fluoxetine, sertraline, and nefazodone in healthy volunteers. J Clin Psychopharmacol. 2004 Feb; 24(1):4-10.
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CYP3A4 is a human microsomal vitamin D 25-hydroxylase. J Bone Miner Res. 2004 Apr; 19(4):680-8.
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6',7'-Dihydroxybergamottin in grapefruit juice and Seville orange juice: effects on cyclosporine disposition, enterocyte CYP3A4, and P-glycoprotein. Clin Pharmacol Ther. 1999 Mar; 65(3):237-44.
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Imidazolyl carboxylic acids as mechanistic probes of flavocytochrome P-450 BM3. Biochemistry. 1998 Nov 10; 37(45):15799-807.
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Mechanisms of enhanced oral availability of CYP3A4 substrates by grapefruit constituents. Decreased enterocyte CYP3A4 concentration and mechanism-based inactivation by furanocoumarins. Drug Metab Dispos. 1997 Nov; 25(11):1228-33.
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Identification of 6',7'-dihydroxybergamottin, a cytochrome P450 inhibitor, in grapefruit juice. Drug Metab Dispos. 1996 Dec; 24(12):1287-90.
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Phytanic acid alpha-oxidation in rat liver mitochondria. Biochim Biophys Acta. 1994 Dec 15; 1201(3):491-7.