"Folic Acid Antagonists" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Inhibitors of the enzyme, dihydrofolate reductase (TETRAHYDROFOLATE DEHYDROGENASE), which converts dihydrofolate (FH2) to tetrahydrofolate (FH4). They are frequently used in cancer chemotherapy. (From AMA, Drug Evaluations Annual, 1994, p2033)
| Descriptor ID |
D005493
|
| MeSH Number(s) |
D27.505.519.389.350
|
| Concept/Terms |
Folic Acid Antagonists- Folic Acid Antagonists
- Acid Antagonists, Folic
- Antagonists, Folic Acid
- Dihydrofolate Reductase Inhibitors
- Inhibitors, Dihydrofolate Reductase
- Reductase Inhibitors, Dihydrofolate
- Antifolates
|
Below are MeSH descriptors whose meaning is more general than "Folic Acid Antagonists".
Below are MeSH descriptors whose meaning is more specific than "Folic Acid Antagonists".
This graph shows the total number of publications written about "Folic Acid Antagonists" by people in this website by year, and whether "Folic Acid Antagonists" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 1996 | 1 | 0 | 1 |
| 1997 | 1 | 0 | 1 |
| 1998 | 1 | 0 | 1 |
| 1999 | 3 | 0 | 3 |
| 2001 | 1 | 0 | 1 |
| 2002 | 1 | 0 | 1 |
| 2008 | 1 | 1 | 2 |
| 2012 | 1 | 0 | 1 |
| 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Folic Acid Antagonists" by people in Profiles.
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New Transmission-Selective Antimalarial Agents through Hit-to-Lead Optimization of 2-([1,1'-Biphenyl]-4-carboxamido)benzoic Acid Derivatives. Chembiochem. 2022 Nov 04; 23(21):e202200427.
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Folinic acid administration after MTX GVHD prophylaxis in pediatric allo-SCT. Bone Marrow Transplant. 2013 Jan; 48(1):46-9.
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DNA damage and homologous recombination signaling induced by thymidylate deprivation. Biochem Pharmacol. 2008 Oct 15; 76(8):987-96.
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Induction of intrachromosomal homologous recombination in human cells by raltitrexed, an inhibitor of thymidylate synthase. DNA Repair (Amst). 2008 Oct 01; 7(10):1624-35.
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Resistance to multiple novel antifolates is mediated via defective drug transport resulting from clustered mutations in the reduced folate carrier gene in human leukaemia cell lines. Biochem J. 2002 Nov 01; 367(Pt 3):741-50.
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Modulation of both endogenous folates and thymidine enhance the therapeutic efficacy of thymidylate synthase inhibitors. Cancer Res. 2001 May 01; 61(9):3675-81.
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Re: Folylpolyglutamyl synthetase gene transfer and glioma antifolate sensitivity in culture and in vivo. J Natl Cancer Inst. 1999 Dec 01; 91(23):2047-50.
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Multiple mechanisms of resistance to polyglutamatable and lipophilic antifolates in mammalian cells: role of increased folylpolyglutamylation, expanded folate pools, and intralysosomal drug sequestration. Mol Pharmacol. 1999 Apr; 55(4):761-9.
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Accumulation of plasma reduced folates after folic acid administration. Semin Oncol. 1999 Apr; 26(2 Suppl 6):38-41.
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A structurally altered human reduced folate carrier with increased folic acid transport mediates a novel mechanism of antifolate resistance. J Biol Chem. 1998 Nov 13; 273(46):30189-98.