HLA-D Antigens

"HLA-D Antigens" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Human immune-response or Class II antigens found mainly, but not exclusively, on B-lymphocytes and produced from genes of the HLA-D locus. They are extremely polymorphic families of glycopeptides, each consisting of two chains, alpha and beta. This group of antigens includes the -DR, -DQ and -DP designations, of which HLA-DR is most studied; some of these glycoproteins are associated with certain diseases, possibly of immune etiology.

Descriptor ID	D006681
MeSH Number(s)	D12.776.395.550.509.400 D12.776.543.550.440.400 D23.050.301.500.400.400 D23.050.301.500.450.400 D23.050.705.552.410.400 D23.050.705.552.450.400
Concept/Terms	HLA-D Antigens HLA-D Antigens HLA D Antigens Human Class II Antigens HLA-D HLA-Dw Antigens Antigens, HLA-Dw HLA Dw Antigens Antigens, HLA-D Antigens, HLA D Immune Response-Associated Antigens, Human Class II Human Antigens Ia-Like Antigens, Human Antigens, Human Ia-Like Human Ia-Like Antigens Ia Like Antigens, Human Immune-Associated Antigens, Human Antigens, Human Immune-Associated Human Immune-Associated Antigens Immune Associated Antigens, Human Immune-Response Antigens, Human Antigens, Human Immune-Response Human Immune-Response Antigens Immune Response Antigens, Human Immune Response Associated Antigens, Human HLA-Dw

Below are MeSH descriptors whose meaning is more general than "HLA-D Antigens".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Glycoproteins [D12.776.395]
Membrane Glycoproteins [D12.776.395.550]
Histocompatibility Antigens Class II [D12.776.395.550.509]
HLA-D Antigens [D12.776.395.550.509.400]
Membrane Proteins [D12.776.543]
Membrane Glycoproteins [D12.776.543.550]
Histocompatibility Antigens Class II [D12.776.543.550.440]
HLA-D Antigens [D12.776.543.550.440.400]
Biological Factors [D23]
Antigens [D23.050]
Antigens, Surface [D23.050.301]
Histocompatibility Antigens [D23.050.301.500]
Histocompatibility Antigens Class II [D23.050.301.500.400]
HLA-D Antigens [D23.050.301.500.400.400]
HLA Antigens [D23.050.301.500.450]
HLA-D Antigens [D23.050.301.500.450.400]
Isoantigens [D23.050.705]
Histocompatibility Antigens [D23.050.705.552]
Histocompatibility Antigens Class II [D23.050.705.552.410]
HLA-D Antigens [D23.050.705.552.410.400]
HLA Antigens [D23.050.705.552.450]
HLA-D Antigens [D23.050.705.552.450.400]

Below are MeSH descriptors whose meaning is related to "HLA-D Antigens".

Below are MeSH descriptors whose meaning is more specific than "HLA-D Antigens".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "HLA-D Antigens" by people in this website by year, and whether "HLA-D Antigens" was a major or minor topic of these publications.

Bar chart showing 12 publications over 10 distinct years, with a maximum of 3 publications in 2011

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	0	1	1
1999	0	1	1
2004	0	1	1
2007	1	0	1
2008	1	0	1
2011	3	0	3
2012	1	0	1
2014	0	1	1
2016	1	0	1
2019	0	1	1

Below are the most recent publications written about "HLA-D Antigens" by people in Profiles.

Abelin JG, Harjanto D, Malloy M, Suri P, Colson T, Goulding SP, Creech AL, Serrano LR, Nasir G, Nasrullah Y, McGann CD, Velez D, Ting YS, Poran A, Rothenberg DA, Chhangawala S, Rubinsteyn A, Hammerbacher J, Gaynor RB, Fritsch EF, Greshock J, Oslund RC, Barthelme D, Addona TA, Arieta CM, Rooney MS. Defining HLA-II Ligand Processing and Binding Rules with Mass Spectrometry Enhances Cancer Epitope Prediction. Immunity. 2019 10 15; 51(4):766-779.e17.

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Raj P, Rai E, Song R, Khan S, Wakeland BE, Viswanathan K, Arana C, Liang C, Zhang B, Dozmorov I, Carr-Johnson F, Mitrovic M, Wiley GB, Kelly JA, Lauwerys BR, Olsen NJ, Cotsapas C, Garcia CK, Wise CA, Harley JB, Nath SK, James JA, Jacob CO, Tsao BP, Pasare C, Karp DR, Li QZ, Gaffney PM, Wakeland EK. Regulatory polymorphisms modulate the expression of HLA class II molecules and promote autoimmunity. Elife. 2016 Feb 15; 5.

View in: PubMed
Akter T, Silver RM, Bogatkevich GS. Recent advances in understanding the pathogenesis of scleroderma-interstitial lung disease. Curr Rheumatol Rep. 2014 Apr; 16(4):411.

View in: PubMed
Hossain A, Radwan FF, Doonan BP, God JM, Zhang L, Bell PD, Haque A. A possible cross-talk between autophagy and apoptosis in generating an immune response in melanoma. Apoptosis. 2012 Oct; 17(10):1066-78.

View in: PubMed
Hossain A, God JM, Radwan FF, Amria S, Zhao D, Bethard JR, Haque A. HLA class II defects in Burkitt lymphoma: bryostatin-1-induced 17 kDa protein restores CD4+ T-cell recognition. Clin Dev Immunol. 2011; 2011:780839.

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Radwan FF, Zhang L, Hossain A, Doonan BP, God JM, Haque A. Mechanisms regulating enhanced human leukocyte antigen class II-mediated CD4 + T cell recognition of human B-cell lymphoma by resveratrol. Leuk Lymphoma. 2012 Feb; 53(2):305-14.

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Zhao D, Amria S, Hossain A, Sundaram K, Komlosi P, Nagarkatti M, Haque A. Enhancement of HLA class II-restricted CD4+ T cell recognition of human melanoma cells following treatment with bryostatin-1. Cell Immunol. 2011; 271(2):392-400.

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Thibodeau J, Bourgeois-Daigneault MC, Huppé G, Tremblay J, Aumont A, Houde M, Bartee E, Brunet A, Gauvreau ME, de Gassart A, Gatti E, Baril M, Cloutier M, Bontron S, Früh K, Lamarre D, Steimle V. Interleukin-10-induced MARCH1 mediates intracellular sequestration of MHC class II in monocytes. Eur J Immunol. 2008 May; 38(5):1225-30.

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Bandyopadhyay A, Arneson L, Beeson C, Sant AJ. The relative energetic contributions of dominant P1 pocket versus hydrogen bonding interactions to peptide:class II stability: implications for the mechanism of DM function. Mol Immunol. 2008 Mar; 45(5):1248-57.

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Satoh T, Pandey JP, Okazaki Y, Yasuoka H, Kawakami Y, Ikeda Y, Kuwana M. Single nucleotide polymorphisms of the inflammatory cytokine genes in adults with chronic immune thrombocytopenic purpura. Br J Haematol. 2004 Mar; 124(6):796-801.

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