"HLA-D Antigens" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Human immune-response or Class II antigens found mainly, but not exclusively, on B-lymphocytes and produced from genes of the HLA-D locus. They are extremely polymorphic families of glycopeptides, each consisting of two chains, alpha and beta. This group of antigens includes the -DR, -DQ and -DP designations, of which HLA-DR is most studied; some of these glycoproteins are associated with certain diseases, possibly of immune etiology.
| Descriptor ID |
D006681
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| MeSH Number(s) |
D12.776.395.550.509.400 D12.776.543.550.440.400 D23.050.301.500.400.400 D23.050.301.500.450.400 D23.050.705.552.410.400 D23.050.705.552.450.400
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| Concept/Terms |
HLA-D Antigens- HLA-D Antigens
- HLA D Antigens
- Human Class II Antigens
- HLA-D
- HLA-Dw Antigens
- Antigens, HLA-Dw
- HLA Dw Antigens
- Antigens, HLA-D
- Antigens, HLA D
- Immune Response-Associated Antigens, Human
- Class II Human Antigens
- Ia-Like Antigens, Human
- Antigens, Human Ia-Like
- Human Ia-Like Antigens
- Ia Like Antigens, Human
- Immune-Associated Antigens, Human
- Antigens, Human Immune-Associated
- Human Immune-Associated Antigens
- Immune Associated Antigens, Human
- Immune-Response Antigens, Human
- Antigens, Human Immune-Response
- Human Immune-Response Antigens
- Immune Response Antigens, Human
- Immune Response Associated Antigens, Human
- HLA-Dw
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Below are MeSH descriptors whose meaning is more general than "HLA-D Antigens".
Below are MeSH descriptors whose meaning is more specific than "HLA-D Antigens".
This graph shows the total number of publications written about "HLA-D Antigens" by people in this website by year, and whether "HLA-D Antigens" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2007 | 1 | 0 | 1 |
| 2008 | 2 | 0 | 2 |
| 2011 | 3 | 0 | 3 |
| 2012 | 1 | 0 | 1 |
| 2014 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "HLA-D Antigens" by people in Profiles.
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Defining HLA-II Ligand Processing and Binding Rules with Mass Spectrometry Enhances Cancer Epitope Prediction. Immunity. 2019 10 15; 51(4):766-779.e17.
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Regulatory polymorphisms modulate the expression of HLA class II molecules and promote autoimmunity. Elife. 2016 Feb 15; 5.
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Recent advances in understanding the pathogenesis of scleroderma-interstitial lung disease. Curr Rheumatol Rep. 2014 Apr; 16(4):411.
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A possible cross-talk between autophagy and apoptosis in generating an immune response in melanoma. Apoptosis. 2012 Oct; 17(10):1066-78.
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HLA class II defects in Burkitt lymphoma: bryostatin-1-induced 17 kDa protein restores CD4+ T-cell recognition. Clin Dev Immunol. 2011; 2011:780839.
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Mechanisms regulating enhanced human leukocyte antigen class II-mediated CD4 + T cell recognition of human B-cell lymphoma by resveratrol. Leuk Lymphoma. 2012 Feb; 53(2):305-14.
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Enhancement of HLA class II-restricted CD4+ T cell recognition of human melanoma cells following treatment with bryostatin-1. Cell Immunol. 2011; 271(2):392-400.
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HLA-DM negatively regulates HLA-DR4-restricted collagen pathogenic peptide presentation and T cell recognition. Eur J Immunol. 2008 Jul; 38(7):1961-70.
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Interleukin-10-induced MARCH1 mediates intracellular sequestration of MHC class II in monocytes. Eur J Immunol. 2008 May; 38(5):1225-30.
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The relative energetic contributions of dominant P1 pocket versus hydrogen bonding interactions to peptide:class II stability: implications for the mechanism of DM function. Mol Immunol. 2008 Mar; 45(5):1248-57.