Sex Hormone-Binding Globulin

"Sex Hormone-Binding Globulin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A glycoprotein migrating as a beta-globulin. Its molecular weight, 52,000 or 95,000-115,000, indicates that it exists as a dimer. The protein binds testosterone, dihydrotestosterone, and estradiol in the plasma. Sex hormone-binding protein has the same amino acid sequence as ANDROGEN-BINDING PROTEIN. They differ by their sites of synthesis and post-translational oligosaccharide modifications.

Descriptor ID	D012738
MeSH Number(s)	D12.776.124.790.223.800 D12.776.157.762 D12.776.377.715.182.800
Concept/Terms	Sex Hormone-Binding Globulin Sex Hormone-Binding Globulin Globulin, Sex Hormone-Binding Hormone-Binding Globulin, Sex Sex Hormone Binding Globulin Testosterone-Estradiol Binding Globulin Binding Globulin, Testosterone-Estradiol Globulin, Testosterone-Estradiol Binding Testosterone Estradiol Binding Globulin Sex Steroid-Binding Protein Sex Steroid Binding Protein Steroid-Binding Protein, Sex

Below are MeSH descriptors whose meaning is more general than "Sex Hormone-Binding Globulin".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Blood Proteins [D12.776.124]
Serum Globulins [D12.776.124.790]
Beta-Globulins [D12.776.124.790.223]
Sex Hormone-Binding Globulin [D12.776.124.790.223.800]
Carrier Proteins [D12.776.157]
Sex Hormone-Binding Globulin [D12.776.157.762]
Globulins [D12.776.377]
Serum Globulins [D12.776.377.715]
Beta-Globulins [D12.776.377.715.182]
Sex Hormone-Binding Globulin [D12.776.377.715.182.800]

Below are MeSH descriptors whose meaning is related to "Sex Hormone-Binding Globulin".

Below are MeSH descriptors whose meaning is more specific than "Sex Hormone-Binding Globulin".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Sex Hormone-Binding Globulin" by people in this website by year, and whether "Sex Hormone-Binding Globulin" was a major or minor topic of these publications.

Bar chart showing 10 publications over 10 distinct years, with a maximum of 1 publications in 1994 and 1995 and 2002 and 2006 and 2008 and 2013 and 2016 and 2018 and 2019 and 2020

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	1	0	1
1995	0	1	1
2002	0	1	1
2006	0	1	1
2008	0	1	1
2013	0	1	1
2016	1	0	1
2018	1	0	1
2019	1	0	1
2020	0	1	1

Below are the most recent publications written about "Sex Hormone-Binding Globulin" by people in Profiles.

Aroda VR, Christophi CA, Edelstein SL, Perreault L, Kim C, Golden SH, Horton E, Mather KJ. Circulating sex hormone binding globulin levels are modified with intensive lifestyle intervention, but their changes did not independently predict diabetes risk in the Diabetes Prevention Program. BMJ Open Diabetes Res Care. 2020 12; 8(2).

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Gyawali P, Martin SA, Heilbronn LK, Vincent AD, Jenkins AJ, Januszewski AS, Adams RJT, O'Loughlin PD, Wittert GA. Higher Serum Sex Hormone-Binding Globulin Levels Are Associated With Incident Cardiovascular Disease in Men. J Clin Endocrinol Metab. 2019 12 01; 104(12):6301-6315.

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Gyawali P, Martin SA, Heilbronn LK, Vincent AD, Jenkins AJ, Januszewski AS, Taylor AW, Adams RJT, O'Loughlin PD, Wittert GA. Cross-sectional and longitudinal determinants of serum sex hormone binding globulin (SHBG) in a cohort of community-dwelling men. PLoS One. 2018; 13(7):e0200078.

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Saade GR, Boggess KA, Sullivan SA, Markenson GR, Iams JD, Coonrod DV, Pereira LM, Esplin MS, Cousins LM, Lam GK, Hoffman MK, Severinsen RD, Pugmire T, Flick JS, Fox AC, Lueth AJ, Rust SR, Mazzola E, Hsu C, Dufford MT, Bradford CL, Ichetovkin IE, Fleischer TC, Polpitiya AD, Critchfield GC, Kearney PE, Boniface JJ, Hickok DE. Development and validation of a spontaneous preterm delivery predictor in asymptomatic women. Am J Obstet Gynecol. 2016 May; 214(5):633.e1-633.e24.

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Pal S, Azad A, Bhatia S, Drabkin H, Costello B, Sarantopoulos J, Kanesvaran R, Lauer R, Starodub A, Hauke R, Sweeney CJ, Hahn NM, Sonpavde G, Richey S, Breen T, Kremmidiotis G, Leske A, Doolin E, Bibby DC, Simpson J, Iglesias J, Hutson T. A Phase I/II Trial of BNC105P with Everolimus in Metastatic Renal Cell Carcinoma. Clin Cancer Res. 2015 Aug 01; 21(15):3420-7.

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Key TJ, Appleby PN, Reeves GK, Travis RC, Alberg AJ, Barricarte A, Berrino F, Krogh V, Sieri S, Brinton LA, Dorgan JF, Dossus L, Dowsett M, Eliassen AH, Fortner RT, Hankinson SE, Helzlsouer KJ, Hoff man-Bolton J, Comstock GW, Kaaks R, Kahle LL, Muti P, Overvad K, Peeters PH, Riboli E, Rinaldi S, Rollison DE, Stanczyk FZ, Trichopoulos D, Tworoger SS, Vineis P. Sex hormones and risk of breast cancer in premenopausal women: a collaborative reanalysis of individual participant data from seven prospective studies. Lancet Oncol. 2013 Sep; 14(10):1009-19.

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Paulo RC, Brundage R, Cosma M, Mielke KL, Bowers CY, Veldhuis JD. Estrogen elevates the peak overnight production rate of acylated ghrelin. J Clin Endocrinol Metab. 2008 Nov; 93(11):4440-7.

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Brundu B, Loucks TL, Adler LJ, Cameron JL, Berga SL. Increased cortisol in the cerebrospinal fluid of women with functional hypothalamic amenorrhea. J Clin Endocrinol Metab. 2006 Apr; 91(4):1561-5.

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Dixon JB, O'Brien PE. Neck circumference a good predictor of raised insulin and free androgen index in obese premenopausal women: changes with weight loss. Clin Endocrinol (Oxf). 2002 Dec; 57(6):769-78.

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Wright NM, Renault J, Willi S, Veldhuis JD, Pandey JP, Gordon L, Key LL, Bell NH. Greater secretion of growth hormone in black than in white men: possible factor in greater bone mineral density--a clinical research center study. J Clin Endocrinol Metab. 1995 Aug; 80(8):2291-7.

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