S-Phase Kinase-Associated Proteins
"S-Phase Kinase-Associated Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of structurally-related proteins that were originally identified by their ability to complex with cyclin proteins (CYCLINS). They share a common domain that binds specifically to F-BOX MOTIFS. They take part in SKP CULLIN F-BOX PROTEIN LIGASES, where they can bind to a variety of F-BOX PROTEINS.
| Descriptor ID |
D044786
|
| MeSH Number(s) |
D12.776.157.743
|
| Concept/Terms |
S-Phase Kinase-Associated Proteins- S-Phase Kinase-Associated Proteins
- Kinase-Associated Proteins, S-Phase
- Proteins, S-Phase Kinase-Associated
- S Phase Kinase Associated Proteins
- Skp Domain Protein
- S-Phase Kinase Associated Protein
- S Phase Kinase Associated Protein
- Skp Domain Proteins
Skp2 Proteins- Skp2 Proteins
- p45(SKP2) Protein
- p45(SKP2)
- Skp2 Protein
- p45 SKP2
- SKP2, p45
- SCF(SKP2)
Skp1 Proteins- Skp1 Proteins
- p19(SKP1) Protein
- Skp1 Protein
- p19 SKP1
- SKP1, p19
|
Below are MeSH descriptors whose meaning is more general than "S-Phase Kinase-Associated Proteins".
Below are MeSH descriptors whose meaning is more specific than "S-Phase Kinase-Associated Proteins".
This graph shows the total number of publications written about "S-Phase Kinase-Associated Proteins" by people in this website by year, and whether "S-Phase Kinase-Associated Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2008 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
| 2012 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2018 | 0 | 1 | 1 |
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Below are the most recent publications written about "S-Phase Kinase-Associated Proteins" by people in Profiles.
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The retinoid X receptor agonist, 9-cis UAB30, inhibits cutaneous T-cell lymphoma proliferation through the SKP2-p27kip1 axis. J Dermatol Sci. 2018 Jun; 90(3):343-356.
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Flavokawain A induces deNEDDylation and Skp2 degradation leading to inhibition of tumorigenesis and cancer progression in the TRAMP transgenic mouse model. Oncotarget. 2015 Dec 08; 6(39):41809-24.
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SCFs in the new millennium. Oncogene. 2014 Apr 17; 33(16):2011-8.
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Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities. Proc Natl Acad Sci U S A. 2012 Aug 21; 109(34):13799-804.
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Regulation of Skp2 levels by the Pim-1 protein kinase. J Biol Chem. 2010 Sep 17; 285(38):29128-37.
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Histidine triad nucleotide-binding protein 1 up-regulates cellular levels of p27KIP1 by targeting ScfSKP2 ubiquitin ligase and Src. J Biol Chem. 2009 Feb 20; 284(8):5265-76.
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AML1/RUNX1 phosphorylation by cyclin-dependent kinases regulates the degradation of AML1/RUNX1 by the anaphase-promoting complex. Mol Cell Biol. 2006 Oct; 26(20):7420-9.
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Mechanism of cell-cycle control: ligating the ligase. Trends Biochem Sci. 2004 Sep; 29(9):453-5.
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Localization of organ of Corti protein II in the adult and developing gerbil cochlea. Hear Res. 1997 Feb; 104(1-2):47-56.