Phosphopyruvate Hydratase

"Phosphopyruvate Hydratase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A hydro-lyase that catalyzes the dehydration of 2-phosphoglycerate to form PHOSPHOENOLPYRUVATE. Several different isoforms of this enzyme exist, each with its own tissue specificity.

Descriptor ID	D010751
MeSH Number(s)	D08.811.520.241.300.500
Concept/Terms	Phosphopyruvate Hydratase Phosphopyruvate Hydratase Hydratase, Phosphopyruvate 2-Phospho-D-Glycerate Hydrolase 2 Phospho D Glycerate Hydrolase Enolase 2-Phospho-D-Glycerate Hydro-Lyase 2 Phospho D Glycerate Hydro Lyase Hydro-Lyase, 2-Phospho-D-Glycerate 2-Phosphoglycerate Dehydratase 2 Phosphoglycerate Dehydratase Dehydratase, 2-Phosphoglycerate gamma-Enolase gamma-Enolase gamma Enolase Nervous System-Specific Enolase Enolase, Nervous System-Specific Nervous System Specific Enolase System-Specific Enolase, Nervous Neuron-Specific Enolase Enolase, Neuron-Specific Neuron Specific Enolase Enolase 2 alpha-Enolase alpha-Enolase alpha Enolase Non-Neuronal Enolase Enolase, Non-Neuronal Non Neuronal Enolase beta-Enolase beta-Enolase beta Enolase Muscle-Specific Enolase Enolase, Muscle-Specific Muscle Specific Enolase Enolase 3

Below are MeSH descriptors whose meaning is more general than "Phosphopyruvate Hydratase".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Lyases [D08.811.520]
Carbon-Oxygen Lyases [D08.811.520.241]
Hydro-Lyases [D08.811.520.241.300]
Phosphopyruvate Hydratase [D08.811.520.241.300.500]

Below are MeSH descriptors whose meaning is related to "Phosphopyruvate Hydratase".

Below are MeSH descriptors whose meaning is more specific than "Phosphopyruvate Hydratase".

Phosphopyruvate Hydratase
tau-Crystallins

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Phosphopyruvate Hydratase" by people in this website by year, and whether "Phosphopyruvate Hydratase" was a major or minor topic of these publications.

Bar chart showing 21 publications over 13 distinct years, with a maximum of 4 publications in 2012

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2001	0	1	1
2003	0	1	1
2004	0	2	2
2006	1	2	3
2008	0	1	1
2010	1	0	1
2012	0	4	4
2014	2	0	2
2015	0	1	1
2016	1	1	2
2017	1	0	1
2020	1	0	1
2021	1	0	1

Below are the most recent publications written about "Phosphopyruvate Hydratase" by people in Profiles.

Sharma S, Watanabe T, Nishimoto T, Takihara T, Mlakar L, Nguyen XX, Sanderson M, Su Y, Chambers RA, Feghali-Bostwick C. E4 engages uPAR and enolase-1 and activates urokinase to exert antifibrotic effects. JCI Insight. 2021 12 22; 6(24).

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Polcyn R, Capone M, Matzelle D, Hossain A, Chandran R, Banik NL, Haque A. Enolase inhibition alters metabolic hormones and inflammatory factors to promote neuroprotection in spinal cord injury. Neurochem Int. 2020 10; 139:104788.

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Haque A, Capone M, Matzelle D, Cox A, Banik NL. Targeting Enolase in Reducing Secondary Damage in Acute Spinal Cord Injury in Rats. Neurochem Res. 2017 Oct; 42(10):2777-2787.

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Lee JH, Wei ZZ, Cao W, Won S, Gu X, Winter M, Dix TA, Wei L, Yu SP. Regulation of therapeutic hypothermia on inflammatory cytokines, microglia polarization, migration and functional recovery after ischemic stroke in mice. Neurobiol Dis. 2016 Dec; 96:248-260.

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Haque A, Ray SK, Cox A, Banik NL. Neuron specific enolase: a promising therapeutic target in acute spinal cord injury. Metab Brain Dis. 2016 06; 31(3):487-95.

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Gu X, Wei ZZ, Espinera A, Lee JH, Ji X, Wei L, Dix TA, Yu SP. Pharmacologically induced hypothermia attenuates traumatic brain injury in neonatal rats. Exp Neurol. 2015 May; 267:135-142.

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God JM, Zhao D, Cameron CA, Amria S, Bethard JR, Haque A. Disruption of HLA class II antigen presentation in Burkitt lymphoma: implication of a 47,000 MW acid labile protein in CD4+ T-cell recognition. Immunology. 2014 Jul; 142(3):492-505.

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Bruschi M, Sinico RA, Moroni G, Pratesi F, Migliorini P, Galetti M, Murtas C, Tincani A, Madaio M, Radice A, Franceschini F, Trezzi B, Bianchi L, Giallongo A, Gatti R, Tardanico R, Scaloni A, D'Ambrosio C, Carnevali ML, Messa P, Ravani P, Barbano G, Bianco B, Bonanni A, Scolari F, Martini A, Candiano G, Allegri L, Ghiggeri GM. Glomerular autoimmune multicomponents of human lupus nephritis in vivo: a-enolase and annexin AI. J Am Soc Nephrol. 2014 Nov; 25(11):2483-98.

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Shih AY, Blinder P, Tsai PS, Friedman B, Stanley G, Lyden PD, Kleinfeld D. The smallest stroke: occlusion of one penetrating vessel leads to infarction and a cognitive deficit. Nat Neurosci. 2013 Jan; 16(1):55-63.

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Londono C, DeKroon RM, Mocanu M, Booe J, Winnik WM, Swank A, Osorio C, Hamlett ED, Alzate O. Proteomic analysis of mice expressing human ApoE demonstrates no differences in global protein solubility between APOE 3 and APOE 4 young mice. Electrophoresis. 2012 Dec; 33(24):3745-55.

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