"Receptors, Somatomedin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Cell surface receptors that bind somatomedins and trigger intracellular changes which influence the behavior of cells. Studies have disclosed two types of receptors for this family of peptide hormones. The type I receptor is homologous to the insulin receptor and has tyrosine kinase activity. The type II receptor is identical to the mannose-6-phosphate receptor which is important in trafficking of lysosomal enzymes.
| Descriptor ID |
D017451
|
| MeSH Number(s) |
D12.776.543.750.750.400.780
|
| Concept/Terms |
Receptors, Somatomedin- Receptors, Somatomedin
- Insulin-Like Growth Factor Receptors
- Insulin Like Growth Factor Receptors
- Somatomedin Receptor
- Receptor, Somatomedin
- Somatomedin Receptors
- Insulin-Like Growth Factor Receptor
- Insulin Like Growth Factor Receptor
- Receptors, Insulin-Like Growth Factors
- Receptors, Insulin Like Growth Factors
|
Below are MeSH descriptors whose meaning is more general than "Receptors, Somatomedin".
Below are MeSH descriptors whose meaning is more specific than "Receptors, Somatomedin".
This graph shows the total number of publications written about "Receptors, Somatomedin" by people in this website by year, and whether "Receptors, Somatomedin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
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Below are the most recent publications written about "Receptors, Somatomedin" by people in Profiles.
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Ectodomain shedding-dependent transactivation of epidermal growth factor receptors in response to insulin-like growth factor type I. Mol Endocrinol. 2004 Nov; 18(11):2727-39.
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Expression of insulin-like growth factor binding protein 2 (IGFBP-2) in Wilms' tumors. Pediatr Pathol. 1994 Jul-Aug; 14(4):723-30.
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Insulin-like growth factor-1 induces tyrosyl phosphorylation of nuclear proteins. J Biol Chem. 1991 Dec 25; 266(36):24241-4.
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Characterization of a novel receptor in toad retina with dual specificity for insulin and insulin-like growth factor I. J Neurochem. 1991 Oct; 57(4):1332-9.
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Regulation of insulin-like growth factor I receptors in diabetic mesangial cells. J Biol Chem. 1991 Feb 05; 266(4):2369-73.
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Role of growth factor synthesis in the acquisition of insulin/insulin-like growth factor I independence in rat mammary carcinoma cells. Cancer Res. 1990 Sep 01; 50(17):5351-7.