"Phencyclidine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is similar to KETAMINE in structure and in many of its effects. Like ketamine, it can produce a dissociative state. It exerts its pharmacological action through inhibition of NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE). As a drug of abuse, it is known as PCP and Angel Dust.
| Descriptor ID |
D010622
|
| MeSH Number(s) |
D03.383.621.699
|
| Concept/Terms |
Phencyclidine- Phencyclidine
- 1-(1-Phenylcyclohexyl)piperidine
- Angel Dust
- Dust, Angel
|
Below are MeSH descriptors whose meaning is more general than "Phencyclidine".
Below are MeSH descriptors whose meaning is more specific than "Phencyclidine".
This graph shows the total number of publications written about "Phencyclidine" by people in this website by year, and whether "Phencyclidine" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
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Below are the most recent publications written about "Phencyclidine" by people in Profiles.
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Amato D, Pum ME, Groos D, Lauber AC, Huston JP, Carey RJ, de Souza Silva MA, Müller CP. Neuropharmacology of light-induced locomotor activation. Neuropharmacology. 2015 Aug; 95:243-51.
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Mintzer JE. The search for better noncholinergic treatment options for Alzheimer's disease. J Clin Psychiatry. 2003; 64 Suppl 9:18-22.
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Boggan W, Middaugh L. Effect of central injection of phencyclidine on QNB accumulation and motor activity. Eur J Pharmacol. 1989 Jul 18; 166(2):123-9.
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Boggan WO, Middaugh LD, Faught K. Effect of dopaminergic drugs on enhancement of the binding of quinuclidinyl benzilate by phencyclidine in vivo. Neuropharmacology. 1989 Jun; 28(6):617-24.
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Boggan WO, Ondo JG. Effect of central administration of phencyclidine on plasma concentrations of luteinizing hormone. Brain Res. 1989 Jan 30; 478(2):382-4.
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Boggan WO, Faught K, Boyd S, Middaugh LD. Parametric studies on phencyclidine enhancement of 3H quinuclidinyl benzilate accumulation in vivo. Pharmacol Biochem Behav. 1988 May; 30(1):31-5.
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Middaugh LD, Favara JP, Boggan WO, Stringer AJ. Discriminative properties of phencyclidine in mice: generalization to ketamine and monohydroxy metabolites. Psychopharmacology (Berl). 1988; 96(3):381-4.
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Boggan WO, Stringer AJ, Faught K, Middaugh LD. Effect of phencyclidine and two monohydroxy metabolites on 3H QNB binding in vivo in rats. Pharmacol Biochem Behav. 1987 Apr; 26(4):847-9.
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Boggan WO, Middaugh LD. Doubtful role for phencyclidine metabolites in PCP enhancement of QNB binding. Pharmacol Biochem Behav. 1987 Apr; 26(4):671-6.
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Zukin SR, Brady KT, Slifer BL, Balster RL. Behavioral and biochemical stereoselectivity of sigma opiate/PCP receptors. Brain Res. 1984 Feb 27; 294(1):174-7.