Mental Retardation, X-Linked

"Mental Retardation, X-Linked" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A class of genetic disorders resulting in INTELLECTUAL DISABILITY that is associated either with mutations of GENES located on the X CHROMOSOME or aberrations in the structure of the X chromosome (SEX CHROMOSOME ABERRATIONS).

Descriptor ID	D038901
MeSH Number(s)	C10.597.606.643.455 C16.320.322.500 C16.320.400.525
Concept/Terms	Mental Retardation, X-Linked Mental Retardation, X-Linked Mental Retardation, X Linked Retardation, X-Linked Mental X-Linked Mental Retardations X-Linked Mental Retardation Disorders X Linked Mental Retardation Disorders X-Linked Mental Retardation Syndromes X Linked Mental Retardation Syndromes X-Linked Mental Retardation X Linked Mental Retardation

Below are MeSH descriptors whose meaning is more general than "Mental Retardation, X-Linked".

Diseases [C]
Nervous System Diseases [C10]
Neurologic Manifestations [C10.597]
Neurobehavioral Manifestations [C10.597.606]
Intellectual Disability [C10.597.606.643]
Mental Retardation, X-Linked [C10.597.606.643.455]
Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
Genetic Diseases, Inborn [C16.320]
Genetic Diseases, X-Linked [C16.320.322]
Mental Retardation, X-Linked [C16.320.322.500]
Heredodegenerative Disorders, Nervous System [C16.320.400]
Mental Retardation, X-Linked [C16.320.400.525]

Below are MeSH descriptors whose meaning is related to "Mental Retardation, X-Linked".

Below are MeSH descriptors whose meaning is more specific than "Mental Retardation, X-Linked".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Mental Retardation, X-Linked" by people in this website by year, and whether "Mental Retardation, X-Linked" was a major or minor topic of these publications.

Bar chart showing 10 publications over 7 distinct years, with a maximum of 3 publications in 2013

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2008	1	0	1
2010	0	1	1
2013	2	1	3
2014	1	0	1
2015	2	0	2
2016	1	0	1
2017	1	0	1

Below are the most recent publications written about "Mental Retardation, X-Linked" by people in Profiles.

Vaidyanathan K, Niranjan T, Selvan N, Teo CF, May M, Patel S, Weatherly B, Skinner C, Opitz J, Carey J, Viskochil D, Gecz J, Shaw M, Peng Y, Alexov E, Wang T, Schwartz C, Wells L. Identification and characterization of a missense mutation in the O-linked ß-N-acetylglucosamine (O-GlcNAc) transferase gene that segregates with X-linked intellectual disability. J Biol Chem. 2017 05 26; 292(21):8948-8963.

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Peng Y, Norris J, Schwartz C, Alexov E. Revealing the Effects of Missense Mutations Causing Snyder-Robinson Syndrome on the Stability and Dimerization of Spermine Synthase. Int J Mol Sci. 2016 Jan 08; 17(1).

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Peng Y, Suryadi J, Yang Y, Kucukkal TG, Cao W, Alexov E. Mutations in the KDM5C ARID Domain and Their Plausible Association with Syndromic Claes-Jensen-Type Disease. Int J Mol Sci. 2015 Nov 13; 16(11):27270-87.

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Matheus MG, Lehman RK, Bonilha L, Holden KR. Redefining the Pediatric Phenotype of X-Linked Monocarboxylate Transporter 8 (MCT8) Deficiency: Implications for Diagnosis and Therapies. J Child Neurol. 2015 Oct; 30(12):1664-8.

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Zhang Z, Martiny V, Lagorce D, Ikeguchi Y, Alexov E, Miteva MA. Rational design of small-molecule stabilizers of spermine synthase dimer by virtual screening and free energy-based approach. PLoS One. 2014; 9(10):e110884.

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Zhang Z, Norris J, Kalscheuer V, Wood T, Wang L, Schwartz C, Alexov E, Van Esch H. A Y328C missense mutation in spermine synthase causes a mild form of Snyder-Robinson syndrome. Hum Mol Genet. 2013 Sep 15; 22(18):3789-97.

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Zhang Z, Zheng Y, Petukh M, Pegg A, Ikeguchi Y, Alexov E. Enhancing human spermine synthase activity by engineered mutations. PLoS Comput Biol. 2013; 9(2):e1002924.

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Zhang Z, Witham S, Petukh M, Moroy G, Miteva M, Ikeguchi Y, Alexov E. A rational free energy-based approach to understanding and targeting disease-causing missense mutations. J Am Med Inform Assoc. 2013 Jul-Aug; 20(4):643-51.

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Zhang Z, Teng S, Wang L, Schwartz CE, Alexov E. Computational analysis of missense mutations causing Snyder-Robinson syndrome. Hum Mutat. 2010 Sep; 31(9):1043-9.

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Rogers RC, Stevenson RE, Simensen RJ, Holden KR, Schwartz CE. Finding new etiologies of mental retardation and hypotonia: X marks the spot. Dev Med Child Neurol. 2008 Feb; 50(2):104-11.

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